cystitis

Nitrofurantoin (Furadantine), an antibiotic, inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections.

Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic agents, such as ifosfamide or cyclophosphamide.

Afacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders.

PD 0299685 is a potent α2δ ligand of the Ca2+ channel for the treatment of interstitial cystitis.

Pentosan Polysulfate is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.

Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.

Cefroxadine is an orally active cephalosporin antibiotic with a broad spectrum and a bactericidal action. It showed excellent results in the treatment of acute uncomplicated cystitis (AUC).

ONO-8130 is an orally available antagonist of EP1 receptor.

Antofloxacin Hydrochloride, a fluoroquinolone antimicrobial, is used to treat acute exacerbation of chronic bronchitis (AECB), acute pyelonephritis(AP), acute cystitis and multiple folliculitis.

AH-9700 fumarate is a the salt form of AH-9700 and a biochemical which has been shown to improve abnormal frequent urination cystitis in a manner different from that of oxybutynin.

GRC-6211 is an oral specific TRPV1 antagonist which decreases bladder overactivity and noxious bladder input in cystitis animal models.