cystitis

Nitrofurantoin (Furadantine), an antibiotic, inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections.

Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic agents, such as ifosfamide or cyclophosphamide.

Cyclophosphamide is an alkylating agent type of anti-tumor drug, and its main target is DNA. Cyclophosphamide inhibits the proliferation of tumor cells by undergoing alkylation reactions with DNA, interfering with the replication and transcription processes of DNA.

Afacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders.

PD 0299685 is a potent α2δ ligand of the Ca2+ channel for the treatment of interstitial cystitis.

Cyclophosphamide hydrate is a synthetic alkylating agent structurally related to nitrogen mustards, with antitumor and immunosuppressive activities. It is widely used in the treatment of various cancers and is also commonly employed to induce animal models of premature ovarian failure, myelosuppression, cystitis, and myocarditis.

Pentosan Polysulfate is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.

Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.

Cefroxadine is an orally active cephalosporin antibiotic with a broad spectrum and a bactericidal action. It showed excellent results in the treatment of acute uncomplicated cystitis (AUC).

ONO-8130 is an orally available antagonist of EP1 receptor.

Antofloxacin Hydrochloride, a fluoroquinolone antimicrobial, is used to treat acute exacerbation of chronic bronchitis (AECB), acute pyelonephritis(AP), acute cystitis and multiple folliculitis.

AH-9700 fumarate is a the salt form of AH-9700 and a biochemical which has been shown to improve abnormal frequent urination cystitis in a manner different from that of oxybutynin.

Protamine sulfate is a polycationic peptide compound with anti-heparin activity. It can neutralize the anticoagulant effects of heparin, enhance lipid-mediated gene transfer, and is commonly used to establish cystitis models.

GRC-6211 is an oral specific TRPV1 antagonist which decreases bladder overactivity and noxious bladder input in cystitis animal models.