concanavalin a

Concanavalin A is a natural product, a phytoalexin (glycan-binding protein). Concanavalin A has antitumor activity and can also induce acute liver injury.

A-770041 is an orally active and selective Lck inhibitor that inhibits concanavalin A-stimulated IL-2 production in whole blood and prevents cardiac allograft rejection. A-770041 reduces pulmonary fibrosis by inhibiting TGF-β production in regulatory T cells.

Concanavalin A (Rhodamine) is a plant-derived lectin that can specifically interact with biomolecules such as polysaccharides and peptides, and is therefore used as a probe tool in biological analysis. Concanavalin A (Rhodamine) is also a substance that can be used as a biomaterial or organic compound in life science research.

Concanavalin A (agarose) consists of Concanavalin A coupled with agarose. This tetrameric metalloprotein lectin, derived from the jack bean Canavalia ensiformis, can bind to molecules containing α-D-mannopyranosyl, α-D-glucopyranosyl, and related spatial residues, facilitating the purification of glycoproteins, polysaccharides, and glycolipids. Additionally, Concanavalin A (agarose) is utilized in various applications, such as the purification of enzyme-antibody conjugates, IgM purification, and membrane vesicle isolation.

PQA-18, an inhibitor of p21-activated kinase 2 (PAK2; IC50 = 10 nM), is derived from Ppc-1 and exhibits immunosuppressive properties. It inhibits IL-2 production in Jurkat T cells induced by Concanavalin A (product number 14951) with an IC50 of 400 nM. Topically applied at 0.1%, PQA-18 reduces the severity of atopic dermatitis, serum IgE levels, and skin thickness in the NC/Nga mouse model. A lower concentration of 0.05% also decreases skin nerve fiber density in NC/Nga mice. Additionally, PQA-18 administered at 4 mg/kg improves graft survival in a rat small intestine transplantation model.

cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.

Ferroptosis-IN-22 is a selective inhibitor of ferroptosis, which functions by targeting NCOA4 and disrupting its interaction with ferritin, exhibiting an EC50 of 520 nM and a Kd value of 0.78 μM. It effectively inhibits ferroptosis induced by various agents (RSL3, Erastin, ML210, FIN56) but does not inhibit cell necrosis induced by H2O2 or apoptosis induced by STS. Additionally, Ferroptosis-IN-22 significantly ameliorates Concanavalin A-induced acute liver injury and can be used in the study of ferroptosis-related diseases.

KF-17625 is an orally active bronchodilator. It inhibits bronchoconstriction induced by Carbachol, Histamine, or Leukotriene D4. Additionally, KF-17625 suppresses phosphodiesterase (PDE) IV in canine trachea with an IC50 of 12 μM and reduces histamine release from rat mast cells induced by Concanavalin-A at a 10 μM concentration with a 44% inhibition rate. This compound is applicable in research related to immunology and inflammation.

AA 344 is an orally active antiallergic agent that inhibits the release of histamine mediated by IgE, IgGa, Concanavalin A, and dextran. It demonstrates inhibitory effects on homologous passive cutaneous anaphylaxis and passive systemic anaphylaxis in guinea pigs. AA 344 selectively suppresses type I allergic reactions.

Benastatin C is a polyketide synthase-derived benastatin found in [Streptomyces] with diverse biological activities. It inhibits glutathione S-transferase (GST; IC50 = 24 μg/ml for the rat liver enzyme) and the esterase activity of isolated porcine pancreatic lipase (IC50 = 10 μg/ml). Benastatin C also increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner.

Ferrichrome (iron-free) is an iron carrier derived from isoxazolates produced by various fungi, including U. sphaerogena, which enhances iron chelation and absorption in these organisms. In bacteria, Ferrichrome (iron-free) can be utilized as an exogenous iron carrier, such as in Pseudomonas aeruginosa and Vibrio parahaemolyticus. Ferrichrome (iron-free) (0.8 μM) inhibits the proliferation of mouse splenic monocytes induced by concanavalin A and reduces the expression of the IL-2 receptor on CD4+ T cells. Furthermore, Ferrichrome (iron-free) inhibits the heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.

Sydowinin B is a xanthone polyketide that has been found inA. sydowiiand has immunosuppressant activity.1It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20.8 μg/ml, respectively).2Sydowinin B inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by cytochalasin B and N-Formyl-Met-Leu-Phe with IC50values of 21.2 and 12.62 μM, respectively.3

Rupatadine (UR-12592, rupatadine) is a potent and orally available dual antagonist of PAF and histamine H1 receptors with Ki values of 0.55 μM and 0.1 μM, respectively, which provides relief of allergic symptoms and anti-inflammatory properties, and is used in allergic rhinitis and chronic urticaria.

Colletodiol is a fungal metabolite found in D. grovesii with immunosuppressant and antiviral activities. It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC50s = 12 and 5 μg/ml, respectively) and inhibits influenza A viral replication in HeLa-IAV-Luc cells.

Remisporine B is a polyketide and derivative of remisporine A that has been found inPenicilliumand has immunosuppressant activity.1,2It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 30.1 and 32.4 μg/ml, respectively).1 1.Liu, H., Chen, S., Liu, W., et al.Polyketides with immunosuppressive activities from mangrove endophytic fungus Penicillium sp. ZJ-SY2Mar. Drugs14(12)217(2016) 2.Kong, F., and Carter, G.T.Remisporine B, a novel dimeric chromenone derived from spontaneous Diels-Alder reaction of remisporine ATetrahedron Lett.44(15)3119-3122(2003)

(-)-Rasfonin is a fungal metabolite found in T. terrophilus that inhibits the proliferation of mouse splenocytes induced by concanavalin A and LPS (IC50s = 0.7 and 0.5 μg/ml, respectively).

Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells.

2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate (ε-dATP), a fluorescent derivative of 2'-deoxyadenosine-5'-O-triphosphate (dATP), promotes sister chromatid exchange in stimulated primary mouse spleen T- and B lymphocytes with LPS or concanavalin A at concentrations of 50 to 150 µM. Utilized in ambiguous base pairing investigations within vinyl chloride-induced mutagenesis research, ε-dATP, along with its related compound ε-ATP—which exhibits an emission peak at 415 nm after being excited at 300 nm—contributes to understanding genetic alterations mechanisms.

Plipastatin A1, a lipopeptide isolated from B. cereus, demonstrates enzyme inhibitory and immunosuppressant properties. It effectively inhibits enzymes phospholipase A2 (PLA2), phospholipase C (PLC), and phospholipase D (PLD) with half-maximal inhibitory concentrations (IC50s) of 2.9, 1.3, and 1.4 µM, respectively. Additionally, at a concentration of 100 µg/ml, plipastatin A1 inhibits lipopolysaccharide (LPS)-induced B cell blastogenesis and T cell blastogenesis triggered by concanavalin A. In vivo studies reveal that a dose of 0.1 mg/animal effectively suppresses delayed-type hypersensitivity in mice.

Soyasapogenol A (Standard) is a reference standard for research and analysis in studies involving Soyasapogenol A. Soyasapogenol A is a natural triterpene that protects against the concanavalin A-induced hepatitis immune response, inhibits hepatocyte apoptosis, and suppresses elevated plasma TNF-α levels. Soyasapogenol A also induces apoptosis in Hep-G2 cells.

Soyasapogenol A is a natural triterpene that protects against the concanavalin A-induced hepatitis immune response, inhibits hepatocyte apoptosis, and suppresses elevated plasma TNF-α levels. Soyasapogenol A also induces apoptosis in Hep-G2 cells.

Pd-C-II has anti-inflammation activity, it can inhibit TNF-α production and iNOS protein expression and inhibit COX-2 protein expression in LPS-stimulated RAW 264.7 cells. Pd-C-II inhibits anaphylactic mediator release from purified mast cells induced by

Concanamycin C, a natural macrolide antibiotic, was initially isolated from Streptomyces and identified as an inhibitor of T-cell proliferation in response to concanavalin A (1,2). It exhibits cytotoxicity to fungi, including yeasts, by inhibiting vacuolar-type ATPases (3,4).

Kp7-6 is a Fas mimetic peptide that disrupts receptor complexes by simultaneously binding to Fas and FasL, thereby blocking downstream apoptotic signaling. Kp7-6 inhibits ERK1-2 phosphorylation, induces IκBα phosphorylation, and activates NF-κB. Kp7-6 suppresses the activation of caspase-8, caspase-3, and JNK, reduces human amylin-induced β-cell apoptosis, and decreases FasL-mediated lymphocyte cytotoxicity and apoptosis. In pancreatic neuroendocrine tumor models, Kp7-6 downregulates local FasL expression, increases CD8+Fas+ T-cell infiltration, and reduces tumor volume. Kp7-6 prevents concanavalin A-induced liver injury in mice and is applicable to research on type 2 diabetes, hepatitis, and pancreatic neuroendocrine tumors.