brain-permeable — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12165	NAChR agonist 1	DUN71755	AChR
	nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.		AChR
T14389	AZD 9272		GluR
	AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.		GluR
T22972	Methoxy-X04		Others
	Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).		Others
T9956	VK-28		Mitochondrial Metabolism , Lipid
	VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.		Mitochondrial Metabolism , Lipid
T1741	AZD1080		GSK-3
	AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.		GSK-3
TQ0026	MDR-1339	DWK-1339	Beta Amyloid , Gamma-secretase
	MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.		Beta Amyloid , Gamma-secretase
T6679	SRT 2104	SRT2104,sirtuin modulator,GSK2245840	Sirtuin
	SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.		Sirtuin
T5490	AK-7		Sirtuin
	AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.		Sirtuin
TQ0238	Lanabecestat	LY3314814,AZD3293	BACE
	Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier, Lanabecestat can be used for the study of neurological diseases like Alzhei...		BACE
T10355	Apyramide		COX
	Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.		COX
T16012	Marizomib	NPI-0052,Salinosporamide A,ML858	Proteasome
	Marizomib (ML858) is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) 20S proteasomes with IC50s of 3.5, 28, and 430 nM, respectiv...		Proteasome
T5468	YF-2		Others , Epigenetic Reader Domain , Histone Acetyltransferase
	YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
T73177	HCAII-IN-9		Carbonic Anhydrase
	hCAII-IN-9 is a potent carbonic anhydrase inhibitor that inhibits hCA II, hCA IX, and hCA XII with IC50s of 1.18 μM and 0.17 μM , and 2.99 μM , respectively. hCAII-IN-9 is not blood-brain barrier permeable.		Carbonic Anhydrase
T13298	Verubulin hydrochloride	MPC-6827 hydrochloride	Microtubule Associated
	Verubulin hydrochloride (MPC-6827 hydrochloride) is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic activities,with potent anticancer activity in human MX-1 brea...		Microtubule Associated
T8702	SKF-83566		Dopamine Receptor , 5-HT Receptor , AChR
	SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM		Dopamine Receptor , 5-HT Receptor , AChR
T33514	MSC 2032964A	MSC-2032964A,MSC2032964A	ASK
	MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 i...		ASK
T61934	Repinotan
	Repinotan (BAY x 3702 free base) is an effective, selective, blood-brain barrier permeable, oral active 5-HT1A receptor agonist. The Ki values of Repinotan are 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex) a...
T4494	CLOZAPINE N-OXIDE		Dopamine Receptor , 5-HT Receptor , AChR , Drug Metabolite
	Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopa...		Dopamine Receptor , 5-HT Receptor , AChR , Drug Metabolite
T4019	Cambinol	SIRT1/2 Inhibitor IV,NSC 112546	Apoptosis , Phospholipase , Sirtuin
	Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Ca...		Apoptosis , Phospholipase , Sirtuin
T77341	GSK-3 inhibitor 4		GSK-3 , CDK
	GSK-3 inhibitor 4 is an orally active and brain-permeable triple inhibitor of GSK-3, CDK2 and CDK5 with inhibitory effects on GSK-3β, GSK-3α, CDK2 and CDK5, with IC50 values of 0.56 nM, 0.45 nM, 0.47 μM, 0.68 μM, respect...		GSK-3 , CDK