biotransformation

Isonicotinic acid, a metabolite of isoniazid and a useful isomer of nicotinic acid, is formed from isoniazid by hydrazinolysis and can be catalyzed by cytochrome P450 enzymes, such as CYP2C.

Naringinase is a hydrolytic enzymatic complex that exhibits α-L-rhamnosidase and β-D-glucosidase activities. It is widely found in nature and is primarily utilized for the biotransformation of steroids, antibiotics, and glycosides.

Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.

1. Biotransformation of glucoAurantio-obtusin towards Aurantio-obtusin increased the toxicity of irinotecan through increased inhibition of SN-38 glucuronidation. 2. Aurantio-obtusin, stimulated chemotactic migration of MC3T3-E1 osteoblast cells in a conc

7-Hydroxy-TSU-68, a derivative and metabolite of TSU-68, originates from the self-induced hydroxylation of TSU-68 in human liver microsomes, indicating its biotransformation pathway [1].

4'-Demethylpodophyllotoxone, an intermediate in the biotransformation pathway of Alternaria alternata S-f6, undergoes further modification with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP). This modification yields a novel compound that exhibits potent inhibitory effects on the human gastric cancer cell line BGC-823 [1].

(±)-Lavandulol, an atypical monoterpene alcohol, undergoes biotransformation by the fungal strain Rhizopus oryzae to yield its oxygenated metabolite [1].

3-epi-Resibufogenin (compound 2) is an anticancer agent obtained through the biotransformation of Resibufogenin by Actinomucor elegans AS 3.2778. It demonstrates cytotoxicity against cancer cells, with IC50 values of 42.5 μM (A549) and 48.4 μM (H1299).