at 527

Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.

C527 is a potent pan DUB enzyme inhibitor with a high affinity for the USP1/UAF1 complex (IC50=0.88 μM).

Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a R-enantiomer of Selisistat (T6111) with much less activity than Selisistat (IC50 of SIRT1 > 100 μM).

CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.

Microginin 527, a compound found in Microcystis, is an inhibitor of protein phosphatase, ACE, and leucine aminopeptidase.

M 66,527 is a bioactive chemical.

PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of inflammatory cells in the tarsal joint of mice with collagen-induced arthritis.

ALG.APV-527 (APV-527) is a bispecific antibody targeting 4-1BB (CD137) and 5T4. It is designed to activate T cells and natural killer (NK) cells through 4-1BB only when it concurrently binds to tumor cells expressing 5T4. ALG.APV-527 demonstrates potent antitumor activity.

Gadoleic acid is a monounsaturated fatty acid.1,2It inhibits the dsDNA binding activity of p53 when used at a concentration of 1.2 nM.1Hepatic levels of gadoleic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet and increased in rats fed a high-cholesterol diet.2 1.Iijima, H., Kasai, N., Chiku, H., et al.The inhibitory action of long-chain fatty acids on the DNA binding activity of p53Lipids41(6)521-527(2006) 2.Serviddio, G., Bellanti, F., Villani, R., et al.Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approachRedox Biol.9296-305(2016)

AT-9010, a triphosphate derivative of AT-527, exhibits strong inhibitory activity against NiRAN, a crucial viral replication function. This compound effectively suppresses the replication of SARS-CoV-2.

AT-9010 tetrasodium is a triphosphate active metabolite derived from AT-527. It acts as a potent inhibitor of NiRAN, a crucial function for viral replication. Furthermore, AT-9010 tetrasodium demonstrates its ability to effectively inhibit the replication of SARS-CoV-2.

AT-9010 triethylamine, a triphosphate active metabolite of AT-527, is a potent inhibitor of the NiRAN enzyme essential for viral replication, effectively inhibiting SARS-CoV-2 replication.