assemblies

Arimoclomol (BRX-220 free base), a co-inducer of heat shock proteins (HSP), is utilized in studies on the treatment of amyotrophic lateral sclerosis (ALS).

Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.

5,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin is a porphyrin derivative capable of forming complexes with metal ions such as zinc (Zn), copper (Cu), and cadmium (Cd). These metal complexes exhibit phototoxicity towards Hep-2 cells, causing cell inactivation through the generation of singlet oxygen.

Arimoclomol citrate (BRX-220 citrate) is a heat shock protein (HSP) co-inducer that enhances Hsp expression, impacts protein aggregation, clears misfolded assemblies, and interacts with the proteasome-ubiquitin system. This compound is known for its ability to protect motor neurons.

Thio-Miltefosine acts as a modulator in membrane rafts, which are nanoscale assemblies of various lipids and proteins that profoundly influence cellular functions. Additionally, it regulates membrane phase behavior on cell-derived giant plasma membrane vesicles.

Amlenetug (Lu AF82422) is a human monoclonal antibody targeting α-synuclein that is in development for multiple system atrophy, demonstrating robust inhibition of α-synuclein seeding induced by diverse fibrillar assemblies in mouse primary neurons and by aggregates derived from MSA brain homogenates, while in vivo studies show that both intracerebral co-injection and peripheral administration effectively suppress α-synuclein seeding and pathological propagation.

SP94 peptide, Cys conjugated, is a liver cancer (HCC) targeting peptide linked with Cys. It is applicable in synthesizing stimulus-responsive peptide nanomaterials (SRPNs), such as platinum nanocluster assemblies (PT-NA), facilitating the entry of PT-NA into HCC cells through mediation of endocytosis. This peptide can be utilized in cancer research.