as-85

AS-85 is a cell permeable ASH1L inhibitor with anti-leukemic activity, inhibits the growth of leukemic cells, increases cLogP, decreases tPSA, and can be used in the study of leukemia.

Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently reduced the number of regurgitations and vomiting and delayed the onset of vomiting. Litoxetine has an affinity for brain 5HT3 receptors (Ki = 85 nM).

JNJ-54717793 is an orally active, brain-penetrating compound that acts as a selective and high-affinity antagonist of the orexin-1 receptor (OX1R) with a plasma EC50 of 85 ng/mL. It demonstrates K_i values of 16 nM for hOX1R (human OX1R) and 700 nM for hOX2R, indicating its strong preference for hOX1R over hOX2R. JNJ-54717793 is recognized for its effectiveness in the treatment of anxiety disorders.

2-Chloro-6-methylpyridine-4-carboxylic acid ,with CAS No. 25462-85-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Chloro-6-methylpyridine-4-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Piperidin-1-yl-benzonitrile ,with CAS No. 1204-85-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Piperidin-1-yl-benzonitrile provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Methyl 5-amino-1-benzothiophene-2-carboxylate ,with CAS No. 20699-85-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Methyl 5-amino-1-benzothiophene-2-carboxylate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(R)-1-Boc-3-(hyroxymethyl)piperidine ,with CAS No. 140695-85-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (R)-1-Boc-3-(hyroxymethyl)piperidine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Indole-4-methanol ,with CAS No. 1074-85-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Indole-4-methanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Ethyl 4-pyridylacetate ,with CAS No. 54401-85-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Ethyl 4-pyridylacetate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-Methyl-2-pyridone ,with CAS No. 694-85-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Methyl-2-pyridone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2,3-Dichloropyrazine ,with CAS No. 4858-85-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2,3-Dichloropyrazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

6-Methoxynicotinonitrile ,with CAS No. 15871-85-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Methoxynicotinonitrile provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-Hydroxy-2-methylindole, with CAS No. 13314-85-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Hydroxy-2-methylindole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3,4-(Methylenedioxyphenyl)ethylamine ,with CAS No. 1484-85-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3,4-(Methylenedioxyphenyl)ethylamine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-Amino-1-phenylpyrazole ,with CAS No. 826-85-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Amino-1-phenylpyrazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

8-Chlorotheophylline ,with CAS No. 85-18-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 8-Chlorotheophylline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.

2,4'-Dichlorobenzophenone, with CAS No. 85-29-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2,4'-Dichlorobenzophenone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-(1H-imidazol-1-ylmethyl)aniline ,with CAS No. 120107-85-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-(1H-imidazol-1-ylmethyl)aniline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-(1H-imidazol-1-ylmethyl)aniline ,with CAS No. 56643-85-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(1H-imidazol-1-ylmethyl)aniline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

[4-(2-Furyl)phenyl]methanol ,with CAS No. 17920-85-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. [4-(2-Furyl)phenyl]methanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

[2-(1-Pyrrolidinyl)-3-pyridinyl]methanol ,with CAS No. 690632-85-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. [2-(1-Pyrrolidinyl)-3-pyridinyl]methanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-(Trifluoromethoxy)benzonitrile ,with CAS No. 63968-85-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-(Trifluoromethoxy)benzonitrile provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Phenoxybenzylamine hydrochloride ,with CAS No. 376637-85-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Phenoxybenzylamine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.