aporphine

(+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mechanism other than prevention of micelle formation or protection of the erythrocyte membrane against osmotic imbalance.

(+)-Magnoflorine iodide (Thalictrine iodide) has anti-inflammatory activity, it can inhibit inflammations.

(+)-Magnoflorine chloride (Escholine chloride) has anti-inflammatory activity, it can inhibit inflammations.

2,3,5,6-Tetramethoxyaporphine, a benzyl isoquinoline alkaloid with antitussive properties, can be extracted from Glaucium flavum Cr. (Family Papaveraceae) [1] [2].

2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.

1,2,3,10-Tetramethoxy-9-(2-hydroxy-4,5-dimethoxybenzyloxy)oxoaporphine is a natural product of Hernandia, Hernandiaceae. The catalog number is TN2479, and the CAS number is 872729-33-4. It can be used as a reference standard.

6-Formyl-1,2,9,10-tetramethoxy-6a,7-dehydroaporphine is a natural product from Aconitum carmichaelii.

1,2-Methylenedioxy-3,10,11-trimethoxyaporphine exerts moderate vessel-relaxing activities with the IC 50 value from 16.50 to 32.81 microM at the test concentrations.

Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) is a natual product .Boldine displays anti-cancer, cytoprotective , anti-oxidant and anti-inflammatory activities.

1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-κB pathway, which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation.

Thalicarpine is a natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent.

Lanuginosine, an aporphine alkaloid, exhibits cytotoxicity against U251.

(+)-N-Formylnorglaucine, an aporphine alkaloid found in the leaves of Unonopsis stipitata, features a formyl group that is connected to the nitrogen within its heterocyclic structure.

Oxonantenine is an oxoaporphine alkaloid isolated from Annona glabra and has been shown to exhibit acetylcholinesterase inhibitory activity. It has a role as a plant metabolite and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is an organic heteropentacyclic compound, an oxacycle, an aromatic ether, an alkaloid antibiotic and an oxoaporphine alkaloid. It derives from an aporphine.

Xylopine, an aporphine alkaloid, exhibits cytotoxic effects on cancer cells by inducing oxidative stress, provoking G2/M cell cycle arrest, and triggering apoptosis [1].

Oxocrebanine, an aporphine alkaloid present in Fissistigma poilanei (Annonaceae) [1], is identified as a constituent of this botanical species.

N-Methylcorydine, an aporphine alkaloid (+)[1], is a chemical compound.

Bulbocapnine hydrochloride, a dopamine receptor inhibitor and an aporphine alkaloid, not only inhibits dopamine synthesis but also exhibits neuroleptic-like, anticonvulsant, and antinociceptive effects [1] [2] [3].

Norisocorydine ((+)-Norisocorydine) is an aporphine alkaloid known for its analgesic and free radical scavenging properties. It has an SC50 value of 14.1 μg/mL in DPPH radical scavenging assays and exhibits analgesic activity in mice.

Norcorydine is an aporphine alkaloid that can be extracted from the leaves of the plant Annona salzmannii (a species of Annona).

Filiformine is a natural aporphine alkaloid with an oxo group.

O-Methylcassythine is an aporphine alkaloid isolated from Cassytha filiformis, exhibiting vasodilatory activity.

(+)-N-Methylhernovine is an aporphine alkaloid that can be isolated from Hernandia nymphaeifolia. It exhibits mild cytotoxicity against cancer cells.

N-Nornuciferine is an aporphine alkaloid derived from lotus leaf that strongly inhibits CYP2D6 with an IC50 of 3.76 μM and Ki of 2.34 μM, and pharmacokinetic studies show rapid absorption into blood with mean Cmax values of 1.71 μg/mL at 0.9 h and 0.57 μg/mL at 1.65 h after administration. Following intravenous dosing at 10 mg/kg, N-Nornuciferine exhibits a wide volume of distribution of 9.48–15.17 L/kg and slow elimination half-lives of 2.09–3.84 h. the oral bioavailability of N-Nornuciferine is estimated at 58.13–79.91%. At 20 mg/kg i.v. dosing, N-Nornuciferine also rapidly crosses the blood–brain barrier, achieving unbound Cmax values of 0.32 μg/mL and 0.16 μg/mL at approximately 0.89–1.22 h.