androgenic

Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.

Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.

4-Diethylaminobenzaldehyde, a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1), exhibits a potent anti-androgenic effect (IC50: 1.71 μM).

p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT

Norgestimate is an acetylated progestinused in combination with ethinyl estradiol as an oral contraceptive.

CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia.

EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage enzyme-selective compound with potential anti-androgenic and anti-tumor activity.

Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.

Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.

2-Isopropyl Thioxanthone has potential anti-estrogenic and anti-androgenic properties.

Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostatic hyperplasia (BPH).

GLPG0492 is a novel selective androgen receptor modulator. After oral dosing, it showed anabolic activity on muscle, strongly dissociated from the androgenic activity on the prostate.

Naminidil (BMS-234303) is an ATP-sensitive potassium channel opener with vasodilatory activity that was developed as a topical medication candidate for the treatment of androgenic alopecia. Naminidil is used in research to investigate potassium channel–mediated vasodilation, hair follicle biology, and localized drug delivery strategies.

1,3,5-Trihydroxyxanthone is a highly cytotoxic natural compound. It against a range of bacteria and yeasts.Anti-androgenic.

Nomegestrol (TX 066 free base) is an orally available, selective and potent full agonist of the progesterone receptor with potent anti-estrogenic, partial anti-androgenic and anti-gonadotropic activity.Nomegestrol is also a contraceptive progestin and is used in the study of endometriosis and meningiomas.

Tigestol, as a derivative of Estrone, exhibits properties that promote muscle growth and possess androgenic and progestogenic effects.

GTx-027 is a non-steroidal selective androgen receptor modulator (SARM) known for its androgen receptor (AR) transcription activation, with an EC50 of 2.8765 nM. It selectively promotes muscle mass (anabolic) without affecting secondary sexual organs (androgenic).

Vinclozolin (Ornalin) is a fungicide with anti-androgenic activity and is commonly used in agriculture.

Androstatrione is an androgenic compound.

Megestrol is a synthetic progestin exhibiting androgenic, corticosteroid, and progestational properties. It stimulates appetite and is indicated for anorexia and weight loss in patients with acquired immunodeficiency syndrome (AIDS).

2-Ethylhexyl(E)-3-(4-(methoxy-D3) phenyl)acrylate is the deuterated form of Octinoxate. Octinoxate (Octyl methoxycinnamate) acts as an agonist of thyroid hormone receptors, leading to a reduction in triiodothyronine (T3) and thyroxine (T4) levels, as well as the transcription levels of type II deiodinase (deio2) related genes in Japanese Medaka. Commonly used as a safe ultraviolet (UV) filter in aquatic environments, Octinoxate inhibits CYP1A1 and CYP1B1, and influences hyaluronic acid (HA) metabolism in human keratinocytes through a PI3K pathway-dependent manner. It also exhibits both anti-estrogenic and anti-androgenic effects in vitro and in vivo.

Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor with an IC50 of 4.2 nM for type II 5α-reductase, demonstrating approximately 100-fold higher affinity for type II than type I. Finasteride acetate can be used for research on benign prostatic hyperplasia (BPH) and androgenic alopecia [1] [2] [3].

Demegestone is a progestin, or a synthetic progestogen, and hence is a progesterone receptor agonist, the biological target of progestogens like progesterone. It has no androgenic activity. Previously used to treat luteal insufficiency.

Piperophos is an organophosphate with anti-androgenic activities.