alcar

Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) is a nutritional supplement composed of the hydrochloride salt form of the acetylated form of the endogenously produced L-carnitine, with potential neuroprotective, cognitive-enhancing, anti-depressive and immunomodulating activities. It may also relieve peripheral neuropathy induced by chemotherapy, diabetes or other diseases. In addition, acetyl-L-carnitine may modulate the immune response by increasing T-lymphocytes maturation and may downregulate pro-inflammatory cytokines in response to viruses, such as SARS-CoV-2. It may also disrupt the ACE2 signaling pathway and inhibit the production of reactive oxygen species (ROS).

Acetyl-L-carnitine(RO 447190) is an amino acid that crosses the blood-brain barrier and is often used as a dietary supplement for neuroinflammation.Acetyl-L-carnitine is neuroprotective and can be used in the study of neurological disorders like Alzheimer's disease.

1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a novel therapy for autoimmune or allergic diseases. 3. Falcarindiol has protective effect against CCl(4) toxicity , in part, be explained by anti-lipid peroxidation activity associated with the induction of the GSTs including GSTA4.

Falcarindiol is an orally active natural polyacetylene compound exhibiting anti-inflammatory and antiproliferative properties. It inhibits NO production in LPS-induced mouse macrophages, reduces tyrosine phosphorylation of JAK1 and JAK2, and modulates STAT1 nuclear translocation, thereby suppressing iNOS expression.

Falcarindiol3-acetate (Compound 5) is a polyacetylenic secondary metabolite found in the underground parts of Pituranthus tortuosus and is a derivative of the known antibacterial compound Falcarindiol.

Isofalcarintriol acts as an NRF2 activator and a selective inhibitor of mitochondrial ATP synthase (mitochondrialATP synthase). It is applicable to aging research.

Falcarinol (Panaxynol) is an Hsp90 inhibitor and CB1 receptor antagonist that inhibits the action of amphetamine on TNF-α-stimulated keratinocytes.

Falcarinolone is a polyacetylene compound that was originally isolated from Aegopodium podagraria L.

(3S,8R,9R)-Isofalcarintriol, a natural polyacetylene compound present in carrot roots, acts as a potent longevity promoter. It improves glucose metabolism and exhibits antitumor activity by influencing cellular respiration and interacting with the α-subunit of mitochondrial ATP synthase, which promotes mitochondrial biosynthesis. Furthermore, (3S,8R,9R)-Isofalcarintriol is utilized in research related to neurodegenerative diseases, metabolic disorders, and aging.'

Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase.

4,4'-Dimethoxybenzil (p-Anisil) is a human intestinal carboxyl esterase (hiCE) inhibitor( Ki : 70 nM).

Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-) enantiomer.

Calcium gluconate monohydrate is a useful organic compound for research related to life sciences. The catalog number is T35350 and the CAS number is 66905-23-5.

Enalaprilat (Enalapril acid) is a potent angiotensin-converting enzyme (ACE) inhibitor that enhances arterial and cardiopulmonary pressure reflex control of sympathetic activity in patients with heart failure, and can be used in the study of cardiovascular disease.

Allixin is a phytoallexin found in garlic (Allium sativum) bulbs. Allixin has weak antimicrobial activity and exerts an anti-promoting activity against skin tumors induced by the chemical 12-O-tetradecanoylphorbol-13-acetate (TPA). Allixin also demonstrates an inhibitory effect on aflatoxin B1-induced mutagenesis.

Type II collagen (from rat sternal cartilage) is a highly purified collagen extracted from rat sternal cartilage. It can stimulate the immune system in animals to produce specific antibodies against this collagen. Additionally, this collagen serves as a substrate for the hydrolysis by matrix metalloproteinases (MMP).

Type II collagen ( from mouse sternal cartilage) is designed for immunization purposes. It can stimulate an animal's immune system to produce specific antibodies against this collagen. Additionally, collagen serves as a hydrolytic substrate for MMP.

Type II collagen (from chicken sternal cartilage) serves as an immunization-grade collagen that stimulates the immune system in animals to produce specific antibodies against this protein. It also functions as a hydrolytic substrate for matrix metalloproteinases (MMP).

Type II collagen (from human sternal cartilage) is a collagen protein used to stimulate the animal immune system to produce specific antibodies against it. This collagen also serves as a hydrolytic substrate for MMP (matrix metalloproteinases).

Type XI collagen, highly purified and derived from human sternal cartilage (Human Type XI collagen, immunization grade), serves as an immunization-grade protein capable of inducing specific antibody production against this collagen in animals. Additionally, collagen functions as a hydrolytic substrate for MMP.

Highly purified Type II collagen, derived from chick sternal cartilage (Chick Type II collagen), is a form of collagen protein that can stimulate the immune system of animals to produce specific antibodies against this collagen. It also serves as a substrate for the hydrolysis by MMP (matrix metalloproteinases).

pacFA L-carnitine is an acylcarnitine lipid.

Acetylcarnitine (ALCAR) is a blood-brain barrier-permeable endogenous acetylated derivative of carnitine. It provides energy to neurons by facilitating fatty acid transport into mitochondria for beta-oxidation, exhibiting antioxidant and neuroprotective activities in Alzheimer's models.