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Results for "
ahu-377
" in TargetMol Product Catalog- Inhibitors & Agonists5
- Isotope Products2
Sacubitril
AHU-377, AHU377, AHU 377
T4574149709-62-6
Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM and is a component of the heart failure medicine LCZ696.
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AHU-377-d4
TMIH-00761884269-07-1
AHU-377-d4 is a deuterated compound of AHU-377.
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Sacubitril sodium
LCZ696, LCZ 696, AHU377, AHU 377
T4574L149690-05-1
Sacubitril sodium (AHU-377) is a potent NEP inhibitor with an IC50=5 nM for the treatment of heart failure or in combination with antihypertensive agents.
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Sacubitril hemicalcium salt
AHU-377 (hemicalcium salt), AHU377 calcium salt
T42001369773-39-6
Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1. Inhibition of neprilysin leads to an increased level of these peptides and, thus, antihypertensive effects. Formulations containing AHU377 in combination with the angiotensin II receptor antagonist valsartan are used to treat hypertension and heart failure.
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Sacubitril-d4 calcium salt
AHU-377-d4 calcium salt
TMIH-0511
Sacubitril-d4 calcium salt is a deuterated compound of Sacubitril calcium salt.
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