adamts-5

ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 with an IC50 of 1.1 µM and can be used in studies about cartilage destruction in arthritis.

Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee.

ADAMTS-5-IN-3 is a highly efficient inhibitor of ADAMTS-5 and ADAMTS-4, useful for studying diseases mediated by these enzymes.

ADAMTS-5-IN-4 (Compound 4b) is a selective inhibitor of ADAMTS5 with an IC₅₀ of 9.4 μM. It significantly hinders Aggrecan degradation in explant models of osteoarthritis and effectively suppresses pseudopodia extension and directional migration in ovarian cancer cells. ADAMTS-5-IN-4 also exhibits significant cytotoxicity towards HEK293T cells, human chondrocytes, and porcine cartilage explants. This compound is applicable in research related to osteoarthritis and ovarian cancer.

ADAMTS-5-IN-2 is a potent inhibitor of ADAMTS-5, exhibiting an IC50 of 0.71 µM, and holds potential for osteoarthritis research.

ADAMTS7-IN-1 (Compound 3a) serves as a potent and selective ADAMTS7 inhibitor, exhibiting a K i value of 9 nM. It is primarily utilized in atherosclerosis research.

T-5224 is a selective inhibitor of the transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically suppresses the DNA-binding activity of c-Fos/c-Jun, thereby inhibiting IL-1β-induced transcriptional upregulation of Mmp-3, Mmp-13, and Adamts-5, without affecting the binding activity of other transcription factors. T-5224 can be used in research on rheumatoid arthritis, osteoarthritis, and cartilage degeneration.

Isecarosmab (M6495) is a monoclonal antibody targeting ADAMTS-5, capable of protecting cartilage and inhibiting ADAMTS-5-mediated degradation of aggrecan, for use in osteoarthritis (OA) research.

T-5224-d8 is the deuterium-labeled form of T-5224. T-5224 acts as a selective inhibitor of the transcription factor c-Fos/activator protein (AP)-1, demonstrating anti-inflammatory properties. It specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting the binding activity of other transcription factors. T-5224 also suppresses the transcriptional upregulation of IL-1β-induced Mmp-3, Mmp-13, and Adamts-5.

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for ADAMTS-4/ADAMTS-5, useful in the detection of ADAMTS-4 or ADAMTS-5 activity.

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for ADAMTS-4/ADAMTS-5, which is useful for assessing the activity of ADAMTS-4 or ADAMTS-5.