acridone

Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.

3,6-Diamino-9(10H)-acridone is an inhibitor of topoisomerase [1].

Acridone-4-carboxylic acid (ACA) (Compound 2c), a heme-interacting acridone derivative, inhibits free heme-mediated protein oxidation and degradation, and reduces protein carbonyl formation with an IC50 of 43 μM [1].

1,3-Dihydroxy-10-methylacridone is a useful organic compound for research related to life sciences and the catalog number is T131490.

1,7-Dihydroxyacridone, a natural product from *Boenninghausenia albiflora*.

1-Hydroxy-N-methylacridone is a natural product from Ruta chalepensis.

Rutacridone has mutagenicity.

1-Hydroxyacridone has potential antiviral activity.

1,3-Dihydroxy-2,4-diprenylacridone is a natural product for research related to life sciences. The catalog number is TN6171 and the CAS number is 1205687-48-4.

10-methyl-9-(phenoxycarbonyl) Acridinium is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfates, and other oxidants in alkaline conditions

STING IN 42 has STING inhibitory activity and can block palmitoylation of STING proteins and downstream STING signaling. STING IN 42 has good pharmacokinetic properties and can effectively inhibit STING mediated inflammation in mice treated with 10-carboxymethyl-9-acridone (CMA) and Trex1-/- mice orally.

ER 27319 maleate is an acridone-derived small-molecule inhibitor that selectively suppresses SYK tyrosine phosphorylation and kinase activity, inhibits antigen-induced mediator release from human and rat mast cells with micromolar potency, and is widely applied in experimental studies of allergic and immune-mediated diseases.

Atalaphillinine is an acridone alkaloid.

5,7,8-Trimethoxydictamnine is a quinoline alkaloid that has been found inRutaceaeand has antimalarial activity.1It is active against chloroquine-sensitive and -resistant strains ofP. falciparum(IC50s =19.9 and 5.72 μg/ml, respectively). 1.Basco, L.K.M., S., Skaltsounis, A.-L., Ravvelomanantsoa, N., et al.In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparumAntimicrob. Agents Chemother.38(5)1169-1171(1994)

Evoxanthine is an alkaloid that has been found in O. renieri and has antimalarial and anticancer activities.1,2 It is active against P. falciparum with an IC50 value of 67.6 μg/ml.1 Evoxanthine decreases proliferation of nine sensitive and drug-resistant cancer cell lines (IC50s = 6.11-80.99 μM).2 |1. Khalid, S.A., Farouk, A., Geary, T.G., et al. Potential antimalarial candidates from African plants: And in vitro approach using Plasmodium falciparum. J. Ethnopharmacol. 15(2), 201-209 (1986).|2. Kuete, V., Fouotsa, H., Mbaveng, A.T., et al. Cytotoxicity of a naturally occurring furoquinoline alkaloid and four acridone alkaloids towards multi-factorial drug-resistant cancer cells. Phytomedicine 22(10), 946-951 (2015).

STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)

Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative acting as a Type II DNA topoisomerase (topo II) inhibitor. It specifically targets topo IIα/β subtypes, with IC50 values of 0.17 μM for topo IIα and 0.23 μM for topo IIβ, causing significant DNA damage and inducing apoptosis by triggering the loss of mitochondrial membrane potential [1].

BMS-566419 is an acridone-based inhibitor of inosine 5'-monophosphate dehydrogenase, a rate-limiting enzyme in de novo guanosine nucleotide biosynthesis, and through suppression of lymphocyte proliferation it has demonstrated clinical utility as a research compound for investigating immunosuppression mechanisms and therapeutic strategies in transplant rejection.

ER-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (SYK), effectively impeding both the tyrosine phosphorylation and enzymatic activity of SYK. With an inhibitory concentration (IC50) of 10 µM, this compound suppresses the release of allergic mediators from human and rat mast cells triggered by antigens, making it useful for allergy research [1] [2].

Melicopidine (NSC 34757) is a DNA topoisomerase inhibitor and an acridone alkaloid found in the bark of the Medicosma subsessilis tree. It exhibits potential antitumor effects by binding to DNA or inhibiting the activity of related enzymes.