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Search Result

Search Results for " proteasome-in-1 "

Targets

Proteasome

44

Compounds

2

Natural Products

1750

Recombinant Proteins

3

Libraries

Cat No. Product Name Synonyms Targets
T12561 Proteasome-IN-1 Proteasome
Proteasome-IN-1 is an inhibitor of proteasome.
T81373 Proteasome β2c/i-IN-1 Proteasome
Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].
T63321 20S Proteasome activator 1 Proteasome
20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation o...
T77620 LMTK3-IN-1 c-Met/HGFR
Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway. LMTK3-IN-1 has shown anticancer activity in a variety of cancer c...
T12818 S119-8 Influenza Virus
RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting gen...
T81371 Proteasome-IN-5 Proteasome
Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].
T16795 Rpn11-IN-1 Capzimin intermediate Others
Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM).
T76243 Proteasome-activating peptide 1 TFA
Proteasome-activating peptide 1 TFA is a potent activator of the proteasome, enhancing chymotrypsin-like proteasomal catalytic activity and thereby increasing proteolytic rates both in vitro and in culture. Additionally,...
T62255 20S Proteasome-IN-4
20S Proteasome-IN-4 (Compound 7) is an orally active inhibitor of the 20S proteasome, selectively targeting the parasite form and demonstrating brain penetration capabilities. It exhibits a potent IC50 value of 6.3 nM ag...
T81372 Proteasome-activating peptide 1
Proteasome-activating peptide 1 enhances chymotrypsin-like proteasomal catalytic activity, boosting proteolytic rates both in vitro and within cultured cells. Additionally, it inhibits protein aggregation in a cellular m...
T78847 BC-05 Others
BC-05, an orally active inhibitor targeting CD13 and the proteasome, displays potent inhibition with IC50 values of 0.13 μM against human CD13 and 1.39 μM for the 20S proteasome. It is utilized in the research of multipl...
T68869 TP-110
TP-110 is a new proteasome inhibitor, which shows potent growth inhibition in various tumor cell lines. Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. TP-110 reduced the...
T40255 VCP/p97 inhibitor-1 VCP/p97 inhibitor-1
VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degr...
T75870 PR-39 TFA
PR-39 TFA, a natural peptide rich in proline and arginine with antibacterial properties, acts as a noncompetitive, reversible, and allosteric inhibitor of the proteasome. It specifically attaches to the α7 subunit of the...
T75869 PSI TFA
PSI (TFA) is a potent proteasome inhibitor effective against the proliferation of primary effusion lymphoma (PEL) cells, utilized in the study of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and related lymph...
T76038 Ac-Nle-Pro-Nle-Asp-AMC
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for the 26S proteasome and is utilized in analyzing the proteasome's caspase-like activity [1] [2] [3].
T69880 YW2065
YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-...
T79474 GSPT1 degrader-1 Apoptosis
GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces G0/G1 phase arrest and apoptosis in cells [1].
T80129 Baceridin Proteasome
Baceridin, a cyclic hexapeptide and proteasome inhibitor, can be isolated from the culture medium of Epiphytic Bacillus. It has the ability to impede cell cycle progression and induce apoptosis in tumor cells via a p53-i...
T74878 Enzyme-IN-1
Enzyme-IN-1 (compound 1), a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases, specifically targets and inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. This compound may possess pot...
T18543 Phthalimide-PEG4-MPDM-OH Others
Phthalimide-PEG4-MPDM-OH, a PROTAC linker with a PEGs composition, has applications in the synthesis of various PROTACs. These PROTACs consist of a linker connecting two distinct ligands: one binds to an E3 ubiquitin lig...
T74755 TUS-007
TUS-007, a modified CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) molecule originally derived from a proteasome inhibitor, scarcely affects proteasome activity. It is a potent, orally active degrader...
T17646 Boc-C1-PEG3-C4-OBn Others
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PEG-based PROTAC linker employed in the synthesis of various PROTACs, including PROTAC SGK3 degrader-1. PROTACs are composed of two distinct ligands connected by a linker; one l...
T18544 Phthalimide-PEG4-PDM-OTBS Others
Phthalimide-PEG4-PDM-OTBS is a PROTAC linker comprised of polyethylene glycols (PEGs). This compound is utilized in the synthesis of a range of PROTACs, which consists of two distinct ligands connected by a linker. One l...
T35481 DD 03-171
Potent and selective BTK Degrader (IC50 = 5.1 nM); degrades BTK in a proteasome- and CRBN-dependent manner. Suppresses BTK signaling and proliferation in mantle cell lymphoma (MCL) cells by degrading BTK, IKFZ1, and IKFZ...
T77974 PROTAC BCR-ABL Degrader-1 PROTACs
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1), featuring a 2-oxoethyl linker, promotes Bcr-Abl degradation through the ubiquitin-proteasome pathway and demonstrates antiproliferative effects on K562 cells, suggesting its...
T18649 (±)15-HETE Others
(±)15-HETE is a alkyl chain-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome syste...
T17647 Boc-C1-PEG3-C4-OH Others
Boc-C1-PEG3-C4-OH is an Alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs, which are characterized by their structure comprising two distinct ligands tethered by a linker. One ligand of PROTACs binds t...
T79505 PROTAC TG2 degrader-1 PROTACs
PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM. This compound effectively decreases TG2 levels in ovarian cancer...
T18542 Phthalimide-PEG3-C2-OTs Others
Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker composed of PEGs. It is utilized in the synthesis of various PROTACs, which involve the connection of two distinct ligands through a linker. One ligand is specific ...
T74300 MS143
MS143, a potent AKT degrader (DC50=46 nM and GI50=0.8 µM in PC3 cells), effectively induces AKT degradation through the ubiquitin-proteasome system in both a concentration- and time-dependent manner, leading to the suppr...
T77939 WBC100 14-D-Valine-TPL c-Myc
WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway, primarily utilized in research for c-Myc overexpressing tu...
T74508 SS47
SS47, a PROTAC -based HPK1 degrader , exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the?in?vivo?antitumor efficacy of BCMA CAR-T cell research. HPK1, an?immunos...
T36321 C6 Urea Ceramide
C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It i...
T74792 USP28-IN-2
USP28-IN-2 is a selective USP28 inhibitor (IC50 = 0.3 μM), demonstrating high specificity compared to USP2, USP7, USP8, USP9x, UCHL3, and UCHL5. This compound exhibits cytotoxic effects on cancer cells and induces the de...
T81421 Pomalidomide-C5-Dovitinib PROTACs
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC that links Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity in FLT3-ITD+ acute myeloid leukemia (AML) cells. It promotes the...
T81747 MS6105 PROTACs
MS6105 is a chimeric LDH protein hydrolysis-targeted PROTAC that degrades LDHA and LDHB efficiently, with its activity contingent on both time and the ubiquitin-proteasome system, exhibiting anticancer properties [1]. Ad...
T74635 MS9449 PROTACs
MS9449 is a potent PROTAC EGFR degrader, exhibiting dissociation constants (Kd) of 17 nM for EGFR WT and 10 nM for EGFR L858R. It effectively mediates the degradation of mutant EGFRs via both ubiquitin/proteasome system ...
T37329 PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the...
T74634 MS9427 TFA
MS9427 TFA is a potent PROTAC-based EGFR degrader, exhibiting dissociation constants (Kd) of 7.1 nM for wild-type EGFR and 4.3 nM for the L858R EGFR mutation. It preferentially degrades the mutant EGFR, sparing the wild-...
T74633 MS9427
MS9427 is a potent PROTAC EGFR degrader, demonstrating high affinity for EGFR with dissociation constants (K d s) of 7.1 nM for the wild-type (WT) EGFR and 4.3 nM for the L858R mutant EGFR, indicating selective degradati...
T79718 CaMKIIα-PHOTAC CaMK
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). This molecule facilitates the ubiquitination and subsequent proteasome-medi...
T83856 AP-1
AP-1, a miniaturized proteolysis-targeting chimera (PROTAC) incorporating an anaplastic lymphoma kinase (ALK) ligand connected to (±)-thalidomide via an ultrashort linker, effectively degrades ALK fusion proteins such as...
T37419 Zetomipzomib
KZR-616, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616 has the potential f...

Compounds

Proteasome-IN-1
T12561
Synonym:
Target: Proteasome
Proteasome β2c/i-IN-1
T81373
Synonym:
Target: Proteasome
20S Proteasome activator 1
T63321
Synonym:
Target: Proteasome
LMTK3-IN-1
T77620
Synonym:
Target: c-Met/HGFR
S119-8
T12818
Synonym:
Target: Influenza Virus
Proteasome-IN-5
T81371
Synonym:
Target: Proteasome
Rpn11-IN-1
T16795
Synonym: Capzimin intermediate
Target: Others
Proteasome-activating peptide 1 TFA
T76243
Synonym:
Target:
20S Proteasome-IN-4
T62255
Synonym:
Target:
Proteasome-activating peptide 1
T81372
Synonym:
Target:
BC-05
T78847
Synonym:
Target: Others
TP-110
T68869
Synonym:
Target:
VCP/p97 inhibitor-1
T40255
Synonym: VCP/p97 inhibitor-1
Target:
PR-39 TFA
T75870
Synonym:
Target:
PSI TFA
T75869
Synonym:
Target:
Ac-Nle-Pro-Nle-Asp-AMC
T76038
Synonym:
Target:
YW2065
T69880
Synonym:
Target:
GSPT1 degrader-1
T79474
Synonym:
Target: Apoptosis
Baceridin
T80129
Synonym:
Target: Proteasome
Enzyme-IN-1
T74878
Synonym:
Target:
Phthalimide-PEG4-MPDM-OH
T18543
Synonym:
Target: Others
TUS-007
T74755
Synonym:
Target:
Boc-C1-PEG3-C4-OBn
T17646
Synonym:
Target: Others
Phthalimide-PEG4-PDM-OTBS
T18544
Synonym:
Target: Others
DD 03-171
T35481
Synonym:
Target:
PROTAC BCR-ABL Degrader-1
T77974
Synonym:
Target: PROTACs
(±)15-HETE
T18649
Synonym:
Target: Others
Boc-C1-PEG3-C4-OH
T17647
Synonym:
Target: Others
PROTAC TG2 degrader-1
T79505
Synonym:
Target: PROTACs
Phthalimide-PEG3-C2-OTs
T18542
Synonym:
Target: Others
MS143
T74300
Synonym:
Target:
WBC100
T77939
Synonym: 14-D-Valine-TPL
Target: c-Myc
SS47
T74508
Synonym:
Target:
C6 Urea Ceramide
T36321
Synonym:
Target:
USP28-IN-2
T74792
Synonym:
Target:
Pomalidomide-C5-Dovitinib
T81421
Synonym:
Target: PROTACs
MS6105
T81747
Synonym:
Target: PROTACs
MS9449
T74635
Synonym:
Target: PROTACs
PROTAC IDO1 Degrader-1
T37329
Synonym: PROTAC IDO1 Degrader-1
Target:
MS9427 TFA
T74634
Synonym:
Target:
MS9427
T74633
Synonym:
Target:
CaMKIIα-PHOTAC
T79718
Synonym:
Target: CaMK
AP-1
T83856
Synonym:
Target:
Zetomipzomib
T37419
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T2S1837 Steviol NSC 226902,Hydroxydehydrostevic acid Others
1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...
T75488 Leptosphaerodione
Leptosphaerodione, a compound derived from the Remotididymella sp. fungus, functions as a potent inhibitor of the ubiquitin-proteasome system (UPS) and demonstrates cytotoxic effects in HeLa cells with an IC50 value of 3...

Natural Products

Steviol
T2S1837
Synonym: NSC 226902,Hydroxydehydrostevic acid
Target: Others
Leptosphaerodione
T75488
Synonym:
Target:

Recombinant Proteins

Species：
Human (1430)
Mouse (231)
Cynomolgus (25)
Rat (25)
Chinese hamster (4)
RSV (4)
Phleum pratense (3)
HIV-1 (2)
HIV-2 (2)
Human (2)
Expression System：
HEK293 (1311)
E. coli (216)
Baculovirus-Insect Cells (188)
CHO (14)
Yeast (11)
Human Cells (8)
Baculovirus (2)
Tag：
His (701)
hFc (227)
C-His-Avi (176)
Tag Free (108)
C-His (95)
His,GST (74)
C-hFc (54)
mFc (40)
His,AVI (39)
GST (38)
Cat No. Product Name Species Expression System
TMPY-02101 KEAP1 Protein, Human, Recombinant (His & GST & Avi) Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03888 KEAP1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03432 KEAP1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03614 PSME3 Protein, Human, Recombinant (His) Human E. coli
PSME3, also known as PA28-gamma, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is comp...
TMPH-02300 RAD23A Protein, Human, Recombinant (His) Human E. coli
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chain...
TMPY-04389 MAP3K8 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ...
TMPY-03612 PSME1 Protein, Human, Recombinant (His) Human E. coli
PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed ...
TMPY-03610 PSME2 Protein, Human, Recombinant (His) Human E. coli
PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed ...
TMPJ-01310 TRIM5 Protein, Human, Recombinant (His) Human E. coli
Tripartite motif-containing Motif 5 is a protein that in humans is encoded by the TRIM5 gene.It is a 493 amino acids protein that belongs to the TRIM/RBCC family.It contains 1 B box-type zinc finger, 1 B30.2/SPRY domain ...
TMPH-01522 HIV-2 (subtype A, isolate ROD) Protein Vpx (His) HIV-2 Yeast
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-03509 Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO) SIV E. coli
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-02282 Ubiquilin-1 Protein, Human, Recombinant (His & Myc) Human E. coli
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa...
TMPH-01521 HIV-2 (subtype A, isolate BEN) Protein Vpx (His) HIV-2 E. coli
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-01264 PELI1 Protein, Human, Recombinant (His) Human Baculovirus
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPH-01073 CD81 Protein, Human, Recombinant (His & SUMO) Human E. coli
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalizati...
TMPY-00651 BACE1 Protein, Human, Recombinant (hFc) Human HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-00678 BACE1 Protein, Mouse, Recombinant (His) Mouse HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-00652 BACE1 Protein, Human, Recombinant Human HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPH-01738 NLRP1 Protein, Human, Recombinant (GST) Human E. coli
Acts as the sensor component of the NLRP1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis. Inflammasomes are supramolecular comple...
TMPY-00752 BACE1 Protein, Human, Recombinant (His) Human HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPH-01520 HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc) HIV-1 E. coli
During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ...
TMPH-01519 HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc) HIV-1 E. coli
During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ...
TMPH-02633 TRIM21 Protein, Mouse, Recombinant (His) Mouse Baculovirus
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TMPH-02632 TRIM21 Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TMPY-04451 AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
TMPY-02501 CD3D & CD3E Heterodimer Protein, Human, Recombinant Human HEK293
TMPY-03745 CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) Human HEK293
TMPY-03878 Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) Human HEK293
Integrin alpha-5, also known as ITGA5, is a single-pass type I membrane protein which belongs to the integrin alpha chain family. ITGA5 contains 7 FG-GAP repeats. Alpha chain 5 undergoes post-translational cleavage in th...
TMPY-01281 ACVR2B Protein, Mouse, Recombinant (His) Mouse HEK293
ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of ...
TMPY-01949 CD19 Protein, Human, Recombinant (His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-01386 CD155/PVR Protein, Human, Recombinant (His) Human HEK293
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originall...
TMPY-04493 BCMA/TNFRSF17 Protein, Human, Recombinant (rFc) Human HEK293
Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in...
TMPY-01055 IL-4R Protein, Human, Recombinant (His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-03524 B7-H4 Protein, Human, Recombinant (His) Human HEK293
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are express...
TMPY-01834 CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His) Mouse HEK293
Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional...
TMPY-03256 NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His) Human Baculovirus-Insect Cells
KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei...
TMPY-01247 FLT3 Protein, Human, Recombinant (T227M, His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPY-05275 CD79B Protein, Human, Recombinant (His) Human HEK293
TMPY-00381 PSMA Protein, Human, Recombinant (His) Human HEK293
Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type II membrane prote...
TMPY-00949 VEGFR3/FLT4 Protein, Human, Recombinant (His) Human HEK293
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-01146 Insulin Receptor Protein, Human, Recombinant (long isoform, His) Human HEK293
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta...
TMPY-01431 L1CAM Protein, Human, Recombinant (His) Human HEK293
L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brai...
TMPY-05357 GCDH Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
TMPY-00828 Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His) Human HEK293
Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfat...
TMPY-04730 LAG-3 Protein, Human, Recombinant (His) Human HEK293
LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfami...
TMPY-01885 Human RSV (B1) glycoprotein G/RSV-G Protein (His) RSV HEK293
Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneum...
TMPY-01475 Jagged 1 Protein, Human, Recombinant (His) Human HEK293
Protein Jagged 1, also known as JAG1, JAGL1, and CD339, is a single-pass type I membrane protein that contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expre...
TMPY-04333 LRRC15 Protein, Human, Recombinant (hFc) Human HEK293
LRRC15 (Leucine-Rich Repeat Containing 15) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The tumor antigen 15-leucine-rich repeat-containing membrane protein (LRRC15) is a transmemb...
TMPY-05306 TRIM21 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
TMPY-05131 PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec...
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KEAP1 Protein, Human, Recombinant (His & GST & Avi)
TMPY-02101
Species: Human
Expression System: Baculovirus-Insect Cells
KEAP1 Protein, Human, Recombinant (His & GST)
TMPY-03888
Species: Human
Expression System: Baculovirus-Insect Cells
KEAP1 Protein, Human, Recombinant
TMPY-03432
Species: Human
Expression System: Baculovirus-Insect Cells
PSME3 Protein, Human, Recombinant (His)
TMPY-03614
Species: Human
Expression System: E. coli
RAD23A Protein, Human, Recombinant (His)
TMPH-02300
Species: Human
Expression System: E. coli
MAP3K8 Protein, Human, Recombinant (GST)
TMPY-04389
Species: Human
Expression System: Baculovirus-Insect Cells
PSME1 Protein, Human, Recombinant (His)
TMPY-03612
Species: Human
Expression System: E. coli
PSME2 Protein, Human, Recombinant (His)
TMPY-03610
Species: Human
Expression System: E. coli
TRIM5 Protein, Human, Recombinant (His)
TMPJ-01310
Species: Human
Expression System: E. coli
HIV-2 (subtype A, isolate ROD) Protein Vpx (His)
TMPH-01522
Species: HIV-2
Expression System: Yeast
Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO)
TMPH-03509
Species: SIV
Expression System: E. coli
Ubiquilin-1 Protein, Human, Recombinant (His & Myc)
TMPH-02282
Species: Human
Expression System: E. coli
HIV-2 (subtype A, isolate BEN) Protein Vpx (His)
TMPH-01521
Species: HIV-2
Expression System: E. coli
PELI1 Protein, Human, Recombinant (His)
TMPH-01264
Species: Human
Expression System: Baculovirus
CD81 Protein, Human, Recombinant (His & SUMO)
TMPH-01073
Species: Human
Expression System: E. coli
BACE1 Protein, Human, Recombinant (hFc)
TMPY-00651
Species: Human
Expression System: HEK293
BACE1 Protein, Mouse, Recombinant (His)
TMPY-00678
Species: Mouse
Expression System: HEK293
BACE1 Protein, Human, Recombinant
TMPY-00652
Species: Human
Expression System: HEK293
NLRP1 Protein, Human, Recombinant (GST)
TMPH-01738
Species: Human
Expression System: E. coli
BACE1 Protein, Human, Recombinant (His)
TMPY-00752
Species: Human
Expression System: HEK293
HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc)
TMPH-01520
Species: HIV-1
Expression System: E. coli
HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc)
TMPH-01519
Species: HIV-1
Expression System: E. coli
TRIM21 Protein, Mouse, Recombinant (His)
TMPH-02633
Species: Mouse
Expression System: Baculovirus
TRIM21 Protein, Mouse, Recombinant (E. coli, His)
TMPH-02632
Species: Mouse
Expression System: E. coli
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)
TMPY-04451
Species: Human
Expression System: Baculovirus-Insect Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant
TMPY-02501
Species: Human
Expression System: HEK293
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)
TMPY-03745
Species: Human
Expression System: HEK293
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)
TMPY-03878
Species: Human
Expression System: HEK293
ACVR2B Protein, Mouse, Recombinant (His)
TMPY-01281
Species: Mouse
Expression System: HEK293
CD19 Protein, Human, Recombinant (His)
TMPY-01949
Species: Human
Expression System: HEK293
CD155/PVR Protein, Human, Recombinant (His)
TMPY-01386
Species: Human
Expression System: HEK293
BCMA/TNFRSF17 Protein, Human, Recombinant (rFc)
TMPY-04493
Species: Human
Expression System: HEK293
IL-4R Protein, Human, Recombinant (His)
TMPY-01055
Species: Human
Expression System: HEK293
B7-H4 Protein, Human, Recombinant (His)
TMPY-03524
Species: Human
Expression System: HEK293
CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His)
TMPY-01834
Species: Mouse
Expression System: HEK293
NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His)
TMPY-03256
Species: Human
Expression System: Baculovirus-Insect Cells
FLT3 Protein, Human, Recombinant (T227M, His)
TMPY-01247
Species: Human
Expression System: HEK293
CD79B Protein, Human, Recombinant (His)
TMPY-05275
Species: Human
Expression System: HEK293
PSMA Protein, Human, Recombinant (His)
TMPY-00381
Species: Human
Expression System: HEK293
VEGFR3/FLT4 Protein, Human, Recombinant (His)
TMPY-00949
Species: Human
Expression System: HEK293
Insulin Receptor Protein, Human, Recombinant (long isoform, His)
TMPY-01146
Species: Human
Expression System: HEK293
L1CAM Protein, Human, Recombinant (His)
TMPY-01431
Species: Human
Expression System: HEK293
GCDH Protein, Human, Recombinant (His)
TMPY-05357
Species: Human
Expression System: Baculovirus-Insect Cells
Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)
TMPY-00828
Species: Human
Expression System: HEK293
LAG-3 Protein, Human, Recombinant (His)
TMPY-04730
Species: Human
Expression System: HEK293
Human RSV (B1) glycoprotein G/RSV-G Protein (His)
TMPY-01885
Species: RSV
Expression System: HEK293
Jagged 1 Protein, Human, Recombinant (His)
TMPY-01475
Species: Human
Expression System: HEK293
LRRC15 Protein, Human, Recombinant (hFc)
TMPY-04333
Species: Human
Expression System: HEK293
TRIM21 Protein, Human, Recombinant (His)
TMPY-05306
Species: Human
Expression System: Baculovirus-Insect Cells
PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-05131
Species: Human
Expression System: HEK293
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Cat No. Product Name
L1100 Protease Inhibitor Library

344 compounds
A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening;
L8500 HIF-1 Signaling Pathway Compound Library

1352 compounds
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；
L3800 NF-κB Signaling Compound Library

740 compounds
A unique collection of 740 compounds targeting NF-κB signaling for high throughput screening and high content screening;

Libraries

Protease Inhibitor Library
L1100
Compounds: 344
HIF-1 Signaling Pathway Compound Library
L8500
Compounds: 1352
NF-κB Signaling Compound Library
L3800
Compounds: 740
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