ltc4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T25687	Leukotriene C4	LTC4,Leukotriene C
	Leukotriene C4 is the conjugation product of Leukotriene A4 and glutathione. It is the major arachidonic acid metabolite in human mast cells, macrophages, and antigen-sensitized lung tissue. It stimulates mucus secretion...
T26519	Ablukast	Ro 23-3544	Leukotriene Receptor
	Ablukast (Ro 23-3544) is a leuktriene receptor antagonist. Ablukast acts as an anti-asthmatic.		Leukotriene Receptor
T3185	R112	(E)-Elafibranor	Syk
	R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase.		Syk
T16280	Nedocromil	FPL 59002	Leukotriene Receptor , Prostaglandin Receptor , Histamine Receptor
	Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
T14326	AS-35		Others
	AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum. With IC50 values of 8 nM, 4 nM and 3 nM, respectively. It has antiallergi...		Others
T16739	RG-12525	NID 525	Leukotriene Receptor , PPAR
	RG-12525（NID 525） is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of guinea pig thin-walled bands, with IC50 values of 2.6 nM, 2.5 nM...		Leukotriene Receptor , PPAR
T67959	Pirodomast		Thrombin , Serine Protease
	Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is weakly or ineffectively antagonistic to guinea pig bronchospas...		Thrombin , Serine Protease
T5714	5-O-Demethylnobiletin	5-DEMETHYLNOBILETIN	Leukotriene Receptor , Lipoxygenase
	5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2.		Leukotriene Receptor , Lipoxygenase
T10054	CI-949		Others
	CI-949 is an allergic mediator release inhibitor, which inhibits leukotriene C4/D4 (LTC4/LTD4), histamine, and thromboxane B2 (TXB2) release (IC50s: 0.5 μM, 11.4 μM and 0.1 μM).		Others
T37492	11-trans Leukotriene C4	11-trans Leukotriene C4
	11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative...
T37980	N-methyl Leukotriene C4	N-methyl Leukotriene C4
	Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione t...
T71499	NZ-107
	NZ-107 is an LTB4, LTC4 and LTD4 antagonist.
T37620	Leukotriene C4 methyl ester
	Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular met...
T13879	(S)-Verapamil hydrochloride	(S)-(-)-Verapamil hydrochloride	Calcium Channel
	(S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads to the death of potentially resistant tumor cells.		Calcium Channel
T11860	LM-1484		Others
	LM-1484 displays a higher affinity for 3H-LTC4 sites and is an antagonist of CysLT1 receptor.		Others
T13855	Quinotolast sodium	FR71021	Others
	Quinotolast sodium inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner in the concentration range of 1-100 μg/mL.		Others
T0694	Pranlukast	ONO-1078	Leukotriene Receptor , IL Receptor , Others , TNF , NF-κB , LTR
	Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered aller...
T71053	AHR-5333 mandelate
	AHR-5333 mandelate is an anti-allergy compound which has been shown to protect against antigen-induced anaphylactic collapse and ascaris antigen-induced skin hypersensitivity. AHR-5333 mandelate has also been shown to in...
T63291	Pranlukast hemihydrate
	Pranlukast hemihydrate is a selective, potent and competitive antagonist of leukotriene.Pranlukast inhibits [3H]LTE4 (Ki: 0.63±0.11 nM), [3H]LTD4 (Ki: 0.99±0.19 nM) and [3H]LTC4 (Ki: 5640 ±680 nM) were bound to the lung ...
T38128	Leukotriene D4	Leukotriene D4 MaxSpec® Standard,LTD4
	Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4...