akr1c3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38684	AKR1C3-IN-4	AKR1C3-IN-4	NADPH
	AKR1C3-IN-4 is a potent and selective inhibitor of aldo-keto reductase 1C3 (AKR1C3) with an IC50 of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research.		NADPH
T7406	AKR1C3-IN-1		NADPH
	AKR1C3-IN-1 is a potent and selective inhibitor of AKR1C3(IC50 of 13 nM).		NADPH
T67846	AKR1C3-IN-9		NADPH
	AKR1C3-IN-9 is a selective Aldo-keto Reductase 1C3 (AKR1C3) inhibitor (IC50= 8.92 nM). AKR1C3-IN-9 can significantly reverse the Doxorubicin (DOX) resistance in a resistant breast cancer cell line.		NADPH
T27990	MDK-0738	AKR1C3-IN-14a,AKR1C3 IN 14a
	MDK-0738 is a potent and selective aldo-keto reductase 1C3 inhibitor.
T61790	AKR1C3-IN-6
	AKR1C3-IN-6 (Compound 1) is a powerful and specific inhibitor of AKR1C3, with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. It demonstrates significant antitumor activity [1].
T61926	AKR1C3-IN-8
	AKR1C3-IN-8 (Compound 5) is an effective and selective AKR1C3 inhibitor (IC50=0.069 μM). AKR1C3-IN-8 has antitumor activity.
T64193	AKR1C3-IN-5
	AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of AKR1C3, derived from drupanin. AKR1C3 enzymes are overexpressed in hormone-dependent prostate and breast tumours. AKR1C3-IN-5 is able to act on MCF-7 cells (IC50: 9.6 ± ...
T61925	AKR1C3-IN-7
	AKR1C3-IN-7 (Compound 13) is an effective and selective AKR1C3 inhibitor (IC50=0.19 μM). AKR1C3-IN-7 has antitumor activity.
T79433	AKR1C3-IN-10
	AKR1C3-IN-10 (compound 5r), a selective inhibitor of AKR1C3 with an IC50 of 51 nM, demonstrates efficacy in a prostate cancer xenograft model [1].
T4529	ASP-9521	ASP9521	NADPH
	ASP-9521 is an effective, specific and orally available AKR1C3 inhibitor (IC50: 11 nM, for human).		NADPH
T67950	S19-1035		NADPH
	S19-1035 is a potent and specific inhibitor of aldo-keto reductase 1C3 (AKR1C3), displaying an inhibitory concentration (IC50) of 3.04 nM. It is primarily utilized in tumor research.		NADPH
T39635	Obafistat		NADPH
	Obafistat is a potent inhibitor of aldo-keto reductase AKR1C3 with an IC50 of 1.2 nM for human AKR1C3.		NADPH
T22458	WEHL-04	7-Bromo-1,2,3,4-tetrahydroquinoline	Others
	WEHL-04 is an intermediate used to prepare (isoquinolinylsulfonyl)benzoic acids as inhibitors of type 5 71-β-hydroxysteroid dehydrogenase AKR1C3. It is also used in the synthesis of 2-aminooctahydrocyclopentalene-3a-carb...		Others
T2899	Liquiritin	Liquiritigenin-4'-O-glucoside,Liquiritoside	Reactive Oxygen Species
	Liquiritin (Liquiritigenin-4'-O-glucoside) (LIQ) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.		Reactive Oxygen Species
T23915	CRT0093964	CRT-0093964,CRT 0093964
	CRT0093964 is a selective AKR1C3 inhibitor.
T78199	S07-1066		Others
	S07-1066, an aldo-keto reductase 1C3 (AKR1C3) inhibitor, enhances doxorubicin (DOX) cytotoxicity by selectively inhibiting AKR1C3-mediated reduction of DOX and reversing DOX resistance in cells with elevated AKR1C3 expre...		Others
T26196	SN34037	SN-34037,SN 34037
	SN34037 is a specific Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) inhibitor.
T69859	Obafistat Na
	Obafistat Na is an aldo-keto reductase AKR1C3 inhibitor.
T23914	CRT0083914	CRT-0083914,CRT 0083914
	CRT0083914 is a potent and selective AKR1C3 inhibitor.
T14151	AKR1C1-IN-1		NADPH
	AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).		NADPH