Nicotiana

Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra.

Anabasine ((S)-Anabasine) is an alkaloid extracted from tobacco, acting as a full agonist of nicotinic acetylcholine receptors (nAChRs) with insecticidal activity. It depolarizes TE671 cells that endogenously express human myotypic nAChRs.

Nicotine 1'-N-oxide ((1′S,2′S)-Nicotine-1'-oxide) is a derivative of nicotine obtained from tobacco smoke condensate.

(S)-(-)-Anatabine ((-)-Anatabine), an alkaloid present in tobacco, is an NRF2 activator that attenuates ovalbumin-induced asthma through oxidative stress and inflammation mitigation as well as up-regulation of Nrf2/HO-1 signaling in rats, and may be used in the study of autoimmune thyroiditis.

Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.

Solanesol (Betulanonaprenol) is a phytochemical present in tobacco leaf. Starting material for synthesis of co-enzyme Q10. Exhibits antiulcer activity.

Delta-hexalactone is a six-membered cyclic lactone widely used in biochemical experiments and drug synthesis research.

2-Propionylpyrrole is a pyrrole derivative widely used in biochemical experiments and drug synthesis research.

N-Methyl-N-propylamine is a secondary amine widely used in biochemical experiments and drug synthesis research.

2-Ethyl-6-methylphenol is a phenol derivative with antioxidant activity, widely used in biochemical experiments and drug synthesis research.

2-Ethyl-5-methylpyridine is a pyridine derivative widely used in biochemical experiments and drug synthesis research.

4-Methyl-1-pentanol exhibits inhibitory activity against SCC-25 cells and NHK cells (normal human keratinocytes), making it useful for cancer research.

Isonicoteine is a structural isomer of pyridine alkaloids and nicotine, widely used in biochemical experiments and drug synthesis research.

2-(Piperidin-2-yl)piperidine is a bipyridine derivative widely used in biochemical experiments and drug synthesis research.

2,2-Dimethylpentanoic acid is a carboxylic acid widely used in biochemical experiments and drug synthesis research.

2,3-Lutidine (2,3-Dimethylpyridine) is a pyridine derivative widely used in biochemical experiments and drug synthesis research.

Pivalic acid is a carboxylic acid exhibiting mild inhibitory effects on K562 cells, suitable for biochemical experiments and drug synthesis research.

5-Methyl-2-furanmethanol is a natural product that can be isolated from the essential oil of D. rupicola Biv. 5-Methyl-2-furanmethanol serves as a key intermediate in organic synthesis for the production of pharmaceuticals, pesticides, and dyes. With its mild, fruity furanol and caramel-like aroma, 5-Methyl-2-furanmethanol is used as a raw material in the fragrance and food additive industries.

(±)-Dihydroactinidiolide is a benzofuranone natural product with a strong, pleasant aroma characterized by musky, tea-like, sweet, milky, and tobacco-like notes. (±)-Dihydroactinidiolide is widely found in plants such as black tea, kiwifruit, mango, and tobacco. (±)-Dihydroactinidiolide also exhibits antibacterial and antioxidant activity.

Cyclopent-4-ene-1,3-dione is a highly reactive cyclic diketone organic compound that has been employed as a key synthetic intermediate in the laboratory synthesis of more complex molecules, including 2-methoxymethylene-Cyclopent-4-ene-1,3-dione and the natural product derivative chrysotrione B (a 2-acylcyclopentene-1,3-dione derivative), Cyclopent-4-ene-1,3-dione was historically used to investigate the influence of sulfhydryl group-specific chemical reagents on the activity of bovine heart phospholipid exchange protein.

7-Amino-4-methylcoumarin is a coumarin compound isolated from the endophytic fungus Xylaria sp. that exhibits broad-spectrum antimicrobial activity. 7-Amino-4-methylcoumarin is an important laser dye that emits in the blue region and can be used to analyze monosaccharides and N-linked oligosaccharides in glycoproteins. 7-Amino-4-methylcoumarin is also used in histopathological analysis, enzyme activity assays, and copper ion detection. The excitation and emission wavelengths are 351 nm and 430 nm, respectively.