Hypericaceae

Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities.

Hyperoside (Hyperin) is a naturally occuring flavonoid compound which shows multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.

2"-O-Galloylhyperin (FT-0689359) found in Pyrola. It increases ruminal fiber fermentability by formed wall-bound lignin in primary maize cell walls.

Vincetoxicoside B, isolated from Polygonum paleaceum Wall. Vincetoxicoside B , quercetin, kaempferol , and (-)-epicatechin show synergistic antifungal activities with the FICI values <0.5.

Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside (Quercetin 3-O-(6''-galloyl)-beta-D-glucopyranoside) is a natural product with potent inhibitory activity against the growth of Microcystis aeruginosa.

Taxifolin 7-O-rhamnoside (Taxifolin 7-O-α-L-rhamnoside) is a natural product derived from Hypericum japonicum.

Hyperforin, a natural product from Hypericum, is commonly used as an antidepressant and also has neurological, inflammatory, antimicrobial, antitumor and antiangiogenic effects. Hyperforin acts as a monoamine reuptake inhibitor (MRI) in vitro, including serotonin, norepinephrine, dopamine, GABA, and glutamate, with an IC 50 of ≈0.1 μg/mL. Hyperforin is also capable of inducing the cytochrome P450 enzymes, CYP3A4 and CYP2C9, through binding to and activation of the pregnane X receptor. Hyperforin is capable of activating TRPC6 channels by binding to a specific motif.

Protohypericin, a naphthodianthrone derivative found in the plant Hypericum perforatum, exhibits photocytotoxicity and is utilized in tumor necrosis targeted radiotherapy through its radioiodinated form.

Mauritianin, a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica, is a topoisomerase I inhibitor with cytoprotective activity.

Formoxanthone A may have antibacterial and cytotoxic activities.

6-Deoxyjacareubin exhibits potent antioxidant and antifungal activities. 6-Deoxyjacareubin inhibits platelet activating factor (PAF) receptor with an IC50 of 29.0 microM and can be used in studies about natural PAF receptor antagonists.

Pseudohypericin is a major naphthodianthrone photosensitive pigment found in plants of the genus Hypericum. Pseudohypericin exerts antiretroviral activity by specifically inhibiting protein kinase C (PKC) or interfering with the assembly and maturation of viral particles. Additionally, upon ultrasonic activation, it induces the generation of reactive oxygen species (ROS), thereby triggering cell apoptosis through the mitochondrial-caspase pathway.

2,2-Dimethyl-6-phenylpyrano[3,4-b]pyran-8-one is a natural product derived from the metabolites of Hypericum revolutum ssp.

Lup-20(29)-ene-3bate,23-diol is a natural product from Cratoxylum formosum.

Saropyrone is a natural product from Hypericum Japonicum.

8-Hydroxyhyperforin 8,1-hemiacetal is a natural product for research related to life sciences. The catalog number is TN3282 and the CAS number is 59014-02-7.

5-Hydroxy-1-methoxyxanthone, 1,5-dihydroxyxanthone and 6-deoxyjacareubin are all antifungal against Cladosporium cucumerinum, while they show differing degrees of inhibition of monoamine oxidase A and B.

Tamarixetin-3-O-rutinoside is a natural flavonoid glycoside isolated from plants such as snake root (Psychotria serpens), sea buckthorn (Hippophae rhamnoides), and Astragalus (Astragalus thracicus).

3,8'-Biapigenin is a polyketide synthase-derived biflavonoid identified in Hypericum species and has been reported to exhibit diverse biological activities. 3,8'-Biapigenin inhibits protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 4.5 µM and stimulates glucose uptake in 3T3-L1 adipocyte cells at concentrations of 5 and 10 µM. 3,8'-Biapigenin also inhibits the cytochrome P450 isoforms CYP3A4, CYP2C9, and CYP1A2, with Ki values of 0.038, 0.32, and 0.95 µM, respectively. In isolated rat embryonic hippocampal neurons, 3,8'-Biapigenin reverses cell death induced by kainate and NMDA when applied at a concentration of 10 µM. Furthermore, 3,8'-Biapigenin administered at 8 mg/kg decreases carrageenan-induced paw edema and protects against gastric lesions induced by indomethacin in rats. These findings support the application of 3,8'-Biapigenin as a research tool for investigations involving metabolic regulation, enzyme modulation, neurobiology, inflammatory processes, and xenobiotic metabolism.

BLV is a natural product for research related to life sciences. The catalog number is TN2484 and the CAS number is 146905-24-0.

Protopseudohypericin is a natural product

Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside effectively induces apoptosis through the p53, MAPKs, and mitochondrial apoptotic pathways.

Cadensin D is a natural product for research related to life sciences. The catalog number is TN3562 and the CAS number is 102349-35-9.

Pyrroside B shows stronger antioxidative activity than that of α-tocopherol.