Dendrobium

Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin has antiangiogenic action by inhibiting endothelial metabolism in a JNK/SAPK-dependent manner a

Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.

1. Dendrobine has a slight but demonstrable analgesic and antipyretic action. 2. Dendrobine produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers the blood pressure. 3. Dendrobine on the electrical activity and on amino acid-induced depolarizations of primary afferent terminals were tested on the frog isolated spinal cord.

Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-plant growth and shows germination

Lusianthridin is a natural product from Dendrobium venustum. Lusianthridin exhibits anti-migratory property at nontoxic concentrations. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling.

1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of beta-Asarone(Cis-Isoasarone) and l-dopa may contribute to the treatment of 6-OHDA-induced damage in rats by inhibiting autophagy activity. 4. Beta-Asarone exhibits anti-inflammatory effects by suppressing the production of pro-inflammatory mediators through NF-κB signaling and the JNK pathways in activated microglial cells and might be developed as a promising candidate to treat various neuroinflammatory diseases.

Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway.Gigantol also shows α-glucosidase inhibitory activity.

(-)-Asarinin (Eleutheroside B4) shows antibacterial activity.

Moscatin (Plicatol, 4-methoxyphenanthrene-2,5-diol) is a diphenyl derivative that can be extracted from Dendrobium nobile Lindl. It inhibits arachidonic acid-induced platelet aggregation, and is able to inhibit Candida albicans virulence and growth by down-regulating the expression of genes such as ERG, HSP, and ALS.

Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, JNK, and p38) pathways.

Methyl Kakuol is an agonist of TRPA1 with an EC50 of 0.27 µM and can be used in studies about acting as an active ingredient in MBST constituent Asiasari Radix.

3'-O-Methylbatatasin III is a natural compound from the orchid plant Bletilla splendens with antibiotic activity and antispasmodic activity.3'-O-Methylbatatasin III exhibits antifungal activity.3'-O-Methylbatatasin III is a natural compound from the orchid plant Bletilla splendens with antibiotic activity and antispasmodic activity.

Benzylacetone (4-Phenyl-2-butanone) is an aromatic compound extracted from incense wood. Benzylacetone has appetite-enhancing and exercise-reducing properties. Benzylacetone has a strong and reversible anti-mushroom tyrosinase effect, with IC50 values of 2.8 mM and 0.6 mM for monophenolase and biphenolase effects, respectively.

alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice.

1. Kakuol has antifungal activity, it can completely inhibit the mycelial growth of Botrytis cinerea Pers ex Fr and Cladosporium cucumerinum Ellis & Arthur at 5 microg ml(-1) and 3 microg ml(-1), respectively. 2. kakuol and a derivative analogue are able

(-)-Sesamin is a natural product with neuroprotective effects. It protects against 6-OHDA-induced neurotoxicity by activating ERK1/2-BadSer112 and inhibiting ERK-p38MAPK-JNK1/2-caspase-3 pathways, making it useful for Parkinson's disease research.

Dihydropiceatannol-4'-methylether is a natural product exhibiting affinity for calmodulin in bovine brain in the presence of calcium chloride.

Apigenin-6-C-β-D-xylopyranosyl-8-C-α-L-arabinopyranoside is a natural flavonoid discovered in Dendrobium officinale, possessing antioxidant activity.

Thunalbene shows weak inhibitory activities without cytotoxicity on the production of nitric oxide (NO) which is an important inflammatory mediator.

γ-Asarone is a natural phenylpropene derivative exhibiting inhibitory activity against SK-MEL-2 and A549 cells.

Rotundatin is a natural product from Dendrobium rotundatum.