Combretaceae

Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.

Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.

Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.

Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, exhibits potent antioxidant activity by breaking protein cross-links induced by advanced glycation end-products (AGEs) and inhibiting AGE formation. It may also counteract AGE-induced endothelial cell dysfunction, suggesting it as a potential intervention for diabetic vascular complications.

Phyllanthusiin C is a natural compound obtained from Phyllanthus reticulatus leaf red extract with antimicrobial activity and inhibits lipopolysaccharide (LPS)-induced nitric oxide production by IC cells RAW 264.7.

23-Deoxojessic acid possesses strong cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells, with ED50 values equal to or less than 6 microM.

6'-O-trans-Feruloylnodakenin is a natural product suitable for biochemical experiments and drug synthesis research.

Methyl Ursolate is a natural product demonstrating inhibitory activity against multiple cancer cell lines.

Isopropyl ferulate is a bioactive compound from Rhizoma et Radix Notopterygii (Qianghuo) that exerts strong cytotoxic effects against PANC-1 human pancreatic cancer cells with a PC50 of 17.5 μg/mL, mechanistic analysis of Isopropyl ferulate via network pharmacology implicates Isopropyl ferulate regulate PI3K/Akt/mTOR, ErbB, and IL-17 pathways. Further validated in IMQ-induced and LPS-stimulated model systems, confirmed its significant modulation of PI3K/Akt/mTOR signaling, supporting the relevance of Isopropyl ferulate in cancer therapeutics.

Neochebulagic acid is a natural product

Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ranging between 1.9 and 15.6 microg/mL.

Arjunglucoside II exhibits a moderate free radical scavenging activity.

Aloe-emodin triacetate is a natural anthraquinone ester derivative, applicable for biochemical experiments and medicinal chemistry research.

2,3,8-tri-O-Methyl ellagic acid has antimicrobial activity agaist Vibro cholera, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus cereus, Escherichia coli.