Combretaceae

Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.

Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.

Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.

Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, exhibits potent antioxidant activity by breaking protein cross-links induced by advanced glycation end-products (AGEs) and inhibiting AGE formation. It may also counteract AGE-induced endothelial cell dysfunction, suggesting it as a potential intervention for diabetic vascular complications.

Phyllanthusiin C is a natural compound obtained from Phyllanthus reticulatus leaf red extract with antimicrobial activity and inhibits lipopolysaccharide (LPS)-induced nitric oxide production by IC cells RAW 264.7.

6'-O-trans-Feruloylnodakenin is a natural product suitable for biochemical experiments and drug synthesis research.

23-Deoxojessic acid possesses strong cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells, with ED50 values equal to or less than 6 microM.

3,3'-Di-O-methylellagic acid is a methylated ellagic acid derivative belongs to the polyphenol class of natural products. 3,3'-Di-O-methylellagic acid has been reported to affect acid tolerance–related phenotypes in mycobacteria while exerting minimal effects on overall bacterial growth. In addition, due to its antioxidant properties, 3,3'-Di-O-methylellagic acid is considered to have potential hepatoprotective effects.

Methyl Ursolate is a natural product demonstrating inhibitory activity against multiple cancer cell lines.

Isopropyl ferulate is a bioactive compound from Rhizoma et Radix Notopterygii (Qianghuo) that exerts strong cytotoxic effects against PANC-1 human pancreatic cancer cells with a PC50 of 17.5 μg/mL, mechanistic analysis of Isopropyl ferulate via network pharmacology implicates Isopropyl ferulate regulate PI3K/Akt/mTOR, ErbB, and IL-17 pathways. Further validated in IMQ-induced and LPS-stimulated model systems, confirmed its significant modulation of PI3K/Akt/mTOR signaling, supporting the relevance of Isopropyl ferulate in cancer therapeutics.

Neochebulagic acid is a natural product

Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ranging between 1.9 and 15.6 microg/mL.

Arjunglucoside II exhibits a moderate free radical scavenging activity.

Aloe-emodin triacetate is a natural anthraquinone ester derivative, applicable for biochemical experiments and medicinal chemistry research.

2,3,8-tri-O-Methyl ellagic acid has antimicrobial activity agaist Vibro cholera, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus cereus, Escherichia coli.

Quisqualic acid is an agonist of the AMPA, kainate, and group I metabotropic glutamate receptors. Quisqualic acid is among the most potent AMPA receptor agonists currently characterized. Quisqualic acid induces excitotoxicity and is widely utilized in neuroscience research to selectively destroy neurons in the brain or spinal cord. Quisqualic acid occurs naturally in the seeds of Quisqualis species. Quisqualic acid is particularly valuable for investigations involving glutamatergic neurotransmission, receptor pharmacology, excitotoxic neuronal injury, and neural circuit mapping.