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Natural Product Categories Natural Product Categories Clusiaceae
Clusiaceae, the garcinia family (order Malpighiales), comprises about 14 genera and some 800 species of tropical trees and shrubs. Gamboge (Tenghuang in Chinese), the resin of Garcinia hanburyi Hook f. (Clusiaceae), well known as a natural fresh orange-yellow pigment, is used in TCM for removing stasis, detoxification, hemostasis, and as anthelmintic. In recent years, this resin has been a focus of intense research in phytochemical, pharmacological, synthetic, and biological communities owing to its antitumor activities. Gambogic acid (GA), the best representative of this class of constituents, has the most potential as a broad-spectrum anticancer drug candidate.
- gamma-MangostinNormangostinT4S163731271-07-51. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin could serve as a micronutrient for colon cancer prevention and is a potential lead compound for the development of anti-colon cancer agents. 4. Gamma-Mangostin may acts as an antihypertensive agent , by causing vasorelaxation which is mediated via the NO-cGMP pathway.
- $44
SizeQTY - Gambogic AcidGuttic Acid, Guttatic Acid, Beta-GuttiferrinT61852752-65-0Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.
- $30
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Cited - Gambogenic acidT8201173932-75-7Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.
- $42
SizeQTY Cited - 1-IsomangostinTN254619275-44-61-Isomangostin has cytotoxic and anticomplementary activities.
- $117
SizeQTY - alpha-Mangostinα-Mangostin, MangostinT17176147-11-1alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
- $33
SizeQTY Cited - Beta-mangostinβ-MangostinTN101920931-37-7Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. Beta-mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. Beta-mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic).
- $47
SizeQTY - Morellic acidTN11125304-71-2Morellic acid has anti-cancer activity, it strongly inhibited the migration of HUVEC at a low concentration of 0.5 μM in HUVEC cell migration assay in vitro. Morellic acid also has antiangiogenic activity.
- $83
SizeQTY - 3-IsomangostinT2S163519275-46-83-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial activity with IC50 values in the rang
- $35
SizeQTY - Garcinone CTN167376996-27-5Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effects on certain cancers.
- $38
SizeQTY - GeniposideT221224512-63-8Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation.
- $30
SizeQTY Cited - GardenosideT3S229624512-62-7Gardenoside has hepatoprotective, pain‑relieving, and anti-mastitis effects. it may be a potential therapeutic herb against NASH by suppressed supernatant inflammatory cytokine production and intracellular NFkB activity. Gardenoside may be considere
- $68
SizeQTY Cited - Genipin(+)-GenipinT22106902-77-8Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.
- $50
SizeQTY Cited - Neogambogic acidneo-gambogic acidT572493772-31-7Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors [resulting in an anticancer effect], and may be responsible for the inhibition of proliferation of human breast cancer cell line MCF-7 cells.
- $240
SizeQTY - Geniposidic AcidT213627741-01-1Geniposidic acid, an iridoid glucoside, used in therapy of jaundice, inflammation and hepatic disorders.
- $40
SizeQTY Cited - Gardenin BTN16752798-20-1Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
- $68
SizeQTY - 8-DeoxygartaninTN134133390-41-98-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it has multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD.
- $55
SizeQTY - Garcinone DTN1674107390-08-9Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 activation with IC50 values of 3.2 micr
- $89
SizeQTY - (+)-Lyoniresinol 9'-O-glucoside(+)-Lyoniresinol 3α-O-β-D-glucopyranosideTN541287585-32-8(+)-Lyoniresinol 9'-O-glucoside ((+)-Lyoniresinol 3α-O-β-D-glucopyranoside) is a compound obtained from the root bark of Lycium barbarum, which possesses antimicrobial and antioxidant activity and superoxide dismutase-like activity, and can be used for the study of Gram-positive bacterial infections.
- $81
SizeQTY - GartaninTN167733390-42-0Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±signaling pathways.
- $93
SizeQTY - Genipin 1-β-D-gentiobiosidegenipin-1-b-D-gentiobioside, Genipin gentiobioside, Genipin 1-β-gentiobioside, Genipin 1-gentiobiosideT4S229929307-60-6Genipin 1-β-D-gentiobioside is a natural product for research related to life sciences. The catalog number is T4S2299 and the CAS number is 29307-60-6.
- $35
SizeQTY - Shanzhiside methyl esterT389664421-28-9Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling.
- $30
SizeQTY Cited - Fuscaxanthone CTN165215404-76-9Fuscaxanthone C is a natural product from Garcinia mangostana.
- $100
SizeQTY - 5,7-Dihydroxychromone5,7-Dihydroxy-4H-Chromen-4-OneT5S180531721-94-51. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect against 6-OHDA-induced oxidative stress and apoptosis by activating Nrf2/ARE signal . 3. 5,7-Dihydroxychromone induces the translocation of Nrf2 to the nucleus and increases Nrf2/ARE binding activity which results in the up-regulation of the expression of Nrf2-dependent antioxidant genes, including HO-1, NQO1, and GCLc.
- $39
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