Bupleurum

Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.

Saikosaponin E is a natural product isolated from the herbs of Bupleurum.

α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively.

Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2 (5 μM) induces differentiation of B16 melanoma cells, with potentiation of expressions of tyr

Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.

Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord. It can inhibit NMDA receptor current and persistent sodium current, and inhibit the TNF-α level, the IL-1β production, and cysteine-aspartic acid protease (caspase)-1 activity.

Saikosaponin b3 is isolated from the roots of Bupleurum falcatum L.. Saikosaponin b3 inhibits ACTH-induced lipolysis in the fat cells and exhibits analgesic effects.

1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activation in skeletal muscle and liver.

6''-O-acetylsaikosaponin A is an acetyl saikosaponin isolated from the roots of Bupleurum chinense. Itshows some osteoclast-inhibiting activities

Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.

Saikosaponin F is a natural compound found in Bupleurum (B.) falcatum L.

Prosaikogenin D (Prosapogenin D) is a natural product extracted from the roots of Buleurum bicaule Helm (Apiaceae) with anti-cancer activity.

Kaerophyllin ( (-)-Kaerophylin), a lignan isolated from the traditional Chinese medicine Chai Hu, inhibits activation of hepatic stellate cells by hepatocyte apoptotic vesicles, and protects rat liver from TAA-induced injury and fibrosis by suppressing hepatic inflammation and inhibiting HSC activation.

Saikosaponin G is a natural product

6''-O-Acetylsaikosaponin D is a natural product for research related to life sciences. The catalog number is TN2968 and the CAS number is 64340-45-0.

L-Tryptophan (Standard) is a reference standard of L-tryptophan, suitable for quantitative analysis, quality control, and biochemical studies. L-Tryptophan is an essential amino acid that serves as a precursor for the biosynthesis of serotonin, melatonin, and vitamin B3, and plays important roles in neuroregulation and metabolism. In addition, L-tryptophan and its metabolic pathways can regulate the differentiation potential of bone marrow mesenchymal stem cells and may influence cell proliferation under specific conditions.

Saikosaponin I shows strong inhibition activity against influenza virus WSN33.

16-Deoxysaikogenin F is a natural product for research related to life sciences. The catalog number is TN5957 and the CAS number is 57475-62-4.

2''-O-acetylsaikosaponin A is a natural product for research related to life sciences. The catalog number is TN2781 and the CAS number is 102934-42-9.

Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.

Isosalicifolin is a natural product for research related to life sciences. The catalog number is TN4326 and the CAS number is 156974-99-1.

Saikosaponin H is a natural saponin isolated from Radix bupleuri exhibiting inhibitory activity against Ishikawa cells (IC₅₀=17.21 µM).