P2Y Receptor

P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine diphosphate, and UDP-glucose.To date, 8 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. P2Y receptors mediate responses including vasodilation, blood clotting, and immune response. Due to their ubiquity and variety in function, they are a common biological target in pharmacological development.

Cat. No.	Product name	CAS No.	Purity
T78079	NF546 hydrate		98%
T78079	NF546 (hydrate), a selective non-nucleotide P2Y11 agonist, exhibits a pEC50 value of 6.27 and induces interleukin-8 secretion from human monocyte-derived dendrit...
T78080	PSB-1114 triethylamine		98%
T78080	PSB-1114 triethylamine is a potent, enzymatically stable, P2Y2 receptor agonist with a 134 nM EC50, exhibiting greater than 50-fold selectivity over P2Y4 (EC50 o...
T78583	Uridine 5'-diphosphate	58-98-0	98%
T78583	Uridine 5'-diphosphate acts as a P2Y6 receptor agonist, exhibiting an EC50 value of 0.013 μM for the human P2Y6 receptor [1].
T79196	4-Thiouridine 5′-triphosphate tetralithium	20188-72-1	98%
T79196	4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP), a potent P2Y2 and P2Y4 receptor agonist, exhibits EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4. I...
T79197	4-Thiouridine 5′-triphosphate tetrasodium		98%
T79197	4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium functions as a potent agonist at P2Y 2 and P2Y 4 receptors, with half-maximal effective concentrations (EC...
T5501	Clopidogrel thiolactone	1147350-75-1	98%
T5501	Clopidogrel thiolactone (2-oxoclopidogrel) is a potent P2Y12 receptor inhibitor and a potent antiplatelet aggregation compound.Clopidogrel thiolactone is the act...
T63534	PPTN hydrochloride	1992047-65-0	99.94%
T63534	PPTN hydrochloride is a potent, high-affinity, competitive, highly selective P2Y14 receptor antagonist (KB: 434 pM), but no agonist or antagonist activity at P2Y...
T4743	Uridine 5′-diphosphoglucose disodium salt	28053-08-9	99.83%
T4743	Uridine 5′-diphosphoglucose disodium salt (UDP-Glucose sodium salt) is an endogenous nucleotide sugar involved in glycosyltransferase reactions in Metabolism. It...
T6952	Prasugrel Hydrochloride	389574-19-0	99.79%
T6952	Prasugrel Hydrochloride (LY 640315 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients wi...
T7423	Diquafosol tetrasodium	211427-08-6	99.68%
T7423	Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film ...
T0182L2	(±) Clopidogrel hydrogen sulfate	135046-48-9	99.62%
T0182L2	(±) Clopidogrel hydrogen sulfate (Iscover) , an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in...
T0182L	Clopidogrel hydrogen sulfate	120202-66-6	99.57%
T0182L	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets ...
T28463	PSB-16133 sodium	2089035-40-3	99.36%
T28463	PSB-16133 sodium is a selective P2Y purine receptor variant antagonist with an IC of 233 nM.
T12164	N6-(4-Hydroxybenzyl)adenosine	110505-75-4	99.18%
T12164	N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside) is a platelet aggregation inhibitor.
T5036	Cangrelor tetrasodium	163706-36-3	99.15%
T5036	Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.
T21059	Ticagrelor metabolite M5	1251765-07-7	99.09%
T21059	Ticagrelor metabolite M5 (T437700) is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has...
T23164	PIT	56583-49-4	99.01%
T23164	PIT (2,2'-Pyridylisatogen tosylate) is a specific and non-competitive antagonist of the Purinergic receptor P2Y1 with an IC50 of 0.14 μM for human P2Y1. PIT does...
T0230	Prasugrel	150322-43-3	98.62%
T0230	Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNS...
T4706	Uridine-5'-diphosphate disodium salt	27821-45-0	98.6%
T4706	Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of...
T0182	Clopidogrel	113665-84-2	98.47%
T0182	Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.