P2Y Receptor

P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine diphosphate, and UDP-glucose.To date, 8 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. P2Y receptors mediate responses including vasodilation, blood clotting, and immune response. Due to their ubiquity and variety in function, they are a common biological target in pharmacological development.

Cat. No.	Product name	CAS No.	Purity
T78079	NF546 hydrate		98%
T78079	NF546 (hydrate), a selective non-nucleotide P2Y11 agonist, exhibits a pEC50 value of 6.27 and induces interleukin-8 secretion from human monocyte-derived dendrit...
T78080	PSB-1114 triethylamine		98%
T78080	PSB-1114 triethylamine is a potent, enzymatically stable, P2Y2 receptor agonist with a 134 nM EC50, exhibiting greater than 50-fold selectivity over P2Y4 (EC50 o...
T78583	Uridine 5'-diphosphate	58-98-0	98%
T78583	Uridine 5'-diphosphate acts as a P2Y6 receptor agonist, exhibiting an EC50 value of 0.013 μM for the human P2Y6 receptor [1].
T79196	4-Thiouridine 5′-triphosphate tetralithium	20188-72-1	98%
T79196	4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP), a potent P2Y2 and P2Y4 receptor agonist, exhibits EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4. I...
T79197	4-Thiouridine 5′-triphosphate tetrasodium		98%
T79197	4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium functions as a potent agonist at P2Y 2 and P2Y 4 receptors, with half-maximal effective concentrations (EC...
T5501	Clopidogrel thiolactone	1147350-75-1	98%
T5501	Clopidogrel thiolactone (2-oxoclopidogrel) is a potent P2Y12 receptor inhibitor and a potent antiplatelet aggregation compound.Clopidogrel thiolactone is the act...
T63534	PPTN hydrochloride	1992047-65-0	99.94%
T63534	PPTN hydrochloride is a potent, high-affinity, competitive, highly selective P2Y14 receptor antagonist (KB: 434 pM), but no agonist or antagonist activity at P2Y...
T4132	BPTU	870544-59-5	99.89%
T4132	BPTU (BMS-646786) is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibitio...
T7423	Diquafosol tetrasodium	211427-08-6	99.68%
T7423	Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film ...
T0182L2	(±) Clopidogrel hydrogen sulfate	135046-48-9	99.62%
T0182L2	(±) Clopidogrel hydrogen sulfate (Iscover) , an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in...
T0182L	Clopidogrel hydrogen sulfate	120202-66-6	99.51%
T0182L	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets ...
T12164	N6-(4-Hydroxybenzyl)adenosine	110505-75-4	99.18%
T12164	N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside) is a platelet aggregation inhibitor.
T5036	Cangrelor tetrasodium	163706-36-3	99.15%
T5036	Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.
T21059	Ticagrelor metabolite M5	1251765-07-7	99.09%
T21059	Ticagrelor metabolite M5 (T437700) is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has...
T23164	PIT	56583-49-4	99.01%
T23164	PIT (2,2'-Pyridylisatogen tosylate) is a specific and non-competitive antagonist of the Purinergic receptor P2Y1 with an IC50 of 0.14 μM for human P2Y1. PIT does...
T0230	Prasugrel	150322-43-3	98.62%
T0230	Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNS...
T0182	Clopidogrel	113665-84-2	98.47%
T0182	Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.
T3536	AZD1283	919351-41-0	98.37%
T3536	AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibi...
T11177	Elinogrel	936500-94-6	97.09%
T11177	Elinogrel (PRT060128) is a competitive and reversible antagonist of platelet P2Y12 with IC50 of 20 nM and exhibits potent antiplatelet effects.
T83637	SYL-4	6222-65-7	95.76%
T83637	SYL-4 is a potential P2Y12 receptor antagonist with a Ki value of 7.35 ± 1.72 for use in synthetic dyes.