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P2Y Receptor

P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine diphosphate, and UDP-glucose.To date, 8 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. P2Y receptors mediate responses including vasodilation, blood clotting, and immune response. Due to their ubiquity and variety in function, they are a common biological target in pharmacological development.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78079 NF546 hydrate 98%
NF546 hydrate
NF546 (hydrate), a selective non-nucleotide P2Y11 agonist, exhibits a pEC50 value of 6.27 and induces interleukin-8 secretion from human monocyte-derived dendrit...
T78080 PSB-1114 triethylamine 98%
PSB-1114 triethylamine
PSB-1114 triethylamine is a potent, enzymatically stable, P2Y2 receptor agonist with a 134 nM EC50, exhibiting greater than 50-fold selectivity over P2Y4 (EC50 o...
T78583 Uridine 5'-diphosphate 58-98-0 98%
Uridine 5'-diphosphate
Uridine 5'-diphosphate acts as a P2Y6 receptor agonist, exhibiting an EC50 value of 0.013 μM for the human P2Y6 receptor [1].
T79196 4-Thiouridine 5′-triphosphate tetralithium 20188-72-1 98%
4-Thiouridine 5′-triphosphate tetralithium
4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP), a potent P2Y2 and P2Y4 receptor agonist, exhibits EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4. I...
T79197 4-Thiouridine 5′-triphosphate tetrasodium 98%
4-Thiouridine 5′-triphosphate tetrasodium
4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium functions as a potent agonist at P2Y 2 and P2Y 4 receptors, with half-maximal effective concentrations (EC...
T5501 Clopidogrel thiolactone 1147350-75-1 98%
Clopidogrel thiolactone
Clopidogrel thiolactone (2-oxoclopidogrel) is a potent P2Y12 receptor inhibitor and a potent antiplatelet aggregation compound.Clopidogrel thiolactone is the act...
T63534 PPTN hydrochloride 1992047-65-0 99.94%
PPTN hydrochloride
PPTN hydrochloride is a potent, high-affinity, competitive, highly selective P2Y14 receptor antagonist (KB: 434 pM), but no agonist or antagonist activity at P2Y...
T4132 BPTU 870544-59-5 99.89%
BPTU
BPTU (BMS-646786) is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibitio...
T7423 Diquafosol tetrasodium 211427-08-6 99.68%
Diquafosol tetrasodium
Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film ...
T0182L Clopidogrel hydrogen sulfate 120202-66-6 99.51%
Clopidogrel hydrogen sulfate
Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets ...
T12164 N6-(4-Hydroxybenzyl)adenosine 110505-75-4 99.18%
N6-(4-Hydroxybenzyl)adenosine
N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside) is a platelet aggregation inhibitor.
T5036 Cangrelor tetrasodium 163706-36-3 99.15%
cangrelor tetrasodium
Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.
T21059 Ticagrelor metabolite M5 1251765-07-7 99.09%
Ticagrelor metabolite M5
Ticagrelor metabolite M5 (T437700) is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has...
T23164 PIT 56583-49-4 99.01%
PIT
PIT (2,2'-Pyridylisatogen tosylate) is a specific and non-competitive antagonist of the Purinergic receptor P2Y1 with an IC50 of 0.14 μM for human P2Y1. PIT does...
T0230 Prasugrel 150322-43-3 98.62%
Prasugrel
Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNS...
T0182 Clopidogrel 113665-84-2 98.47%
Clopidogrel
Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.
T3536 AZD1283 919351-41-0 98.37%
AZD1283
AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibi...
T11177 Elinogrel 936500-94-6 97.09%
Elinogrel
Elinogrel (PRT060128) is a competitive and reversible antagonist of platelet P2Y12 with IC50 of 20 nM and exhibits potent antiplatelet effects.
T8582 1-[(5-methylisoxazol-3-yl)methyl]piperazine 173850-51-6 95%
1-[(5-methylisoxazol-3-yl)methyl]piperazine
1-[(5-methylisoxazol-3-yl)methyl]piperazine (Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI)) is a P2Y12 inhibitor.
T34280 Regrelor disodium 676251-22-2 100%
Regrelor disodium
Regrelor disodium (INS 50589) is a p2y12 receptor antagonist that prevents thrombosis, effectively inhibits vascular smooth muscle cell contraction, inhibits cel...
NF546 hydrate
T78079
NF546 (hydrate), a selective non-nucleotide P2Y11 agonist, exhibits a pEC50 value of 6.27 and induces interleukin-8 secretion from human monocyte-derived dendrit...
PSB-1114 triethylamine
T78080
PSB-1114 triethylamine is a potent, enzymatically stable, P2Y2 receptor agonist with a 134 nM EC50, exhibiting greater than 50-fold selectivity over P2Y4 (EC50 o...
Uridine 5'-diphosphate
T78583
Uridine 5'-diphosphate acts as a P2Y6 receptor agonist, exhibiting an EC50 value of 0.013 μM for the human P2Y6 receptor [1].
4-Thiouridine 5′-triphosphate tetralithium
T79196
4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP), a potent P2Y2 and P2Y4 receptor agonist, exhibits EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4. I...
4-Thiouridine 5′-triphosphate tetrasodium
T79197
4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium functions as a potent agonist at P2Y 2 and P2Y 4 receptors, with half-maximal effective concentrations (EC...
Clopidogrel thiolactone
T5501
Clopidogrel thiolactone (2-oxoclopidogrel) is a potent P2Y12 receptor inhibitor and a potent antiplatelet aggregation compound.Clopidogrel thiolactone is the act...
PPTN hydrochloride
T63534
PPTN hydrochloride is a potent, high-affinity, competitive, highly selective P2Y14 receptor antagonist (KB: 434 pM), but no agonist or antagonist activity at P2Y...
BPTU
T4132
BPTU (BMS-646786) is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibitio...
Diquafosol tetrasodium
T7423
Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film ...
Clopidogrel hydrogen sulfate
T0182L
Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets ...
N6-(4-Hydroxybenzyl)adenosine
T12164
N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside) is a platelet aggregation inhibitor.
cangrelor tetrasodium
T5036
Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.
Ticagrelor metabolite M5
T21059
Ticagrelor metabolite M5 (T437700) is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has...
PIT
T23164
PIT (2,2'-Pyridylisatogen tosylate) is a specific and non-competitive antagonist of the Purinergic receptor P2Y1 with an IC50 of 0.14 μM for human P2Y1. PIT does...
Prasugrel
T0230
Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNS...
Clopidogrel
T0182
Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.
AZD1283
T3536
AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibi...
Elinogrel
T11177
Elinogrel (PRT060128) is a competitive and reversible antagonist of platelet P2Y12 with IC50 of 20 nM and exhibits potent antiplatelet effects.
1-[(5-methylisoxazol-3-yl)methyl]piperazine
T8582
1-[(5-methylisoxazol-3-yl)methyl]piperazine (Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI)) is a P2Y12 inhibitor.
Regrelor disodium
T34280
Regrelor disodium (INS 50589) is a p2y12 receptor antagonist that prevents thrombosis, effectively inhibits vascular smooth muscle cell contraction, inhibits cel...
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TargetMol