Neuropathic Pain Modeling

Neuropathic pain is a chronic pain condition caused by injury or dysfunction of the nervous system. Common experimental models include chronic constriction injury (CCI) of the sciatic nerve, spared nerve injury (SNI), and spinal nerve ligation (SNL). These models are widely used to investigate mechanisms of pain hypersensitivity, the role of inflammatory mediators, and to screen and evaluate analgesic drugs.