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Nervous System Disease ModelingEpilepsy Modeling
Epilepsy is a chronic neurological disorder caused by abnormal neuronal discharges in the brain, characterized by sudden seizures and impaired consciousness. Common modeling methods include induction by pilocarpine, pentylenetetrazol (PTZ), and kainic acid (KA). These models are used to study mechanisms of excitatory-inhibitory imbalance, neural circuit remodeling, and to screen antiepileptic drugs.
kainic acid
T15643487-79-6
In the CNS, Kainic acid is an effective agonist at excitatory amino acid receptor subtypes.
- $30
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Bicuculline
Cited
T2850485-49-4
Bicuculline ((+)-Bicuculline) is a light-sensitive competitive antagonist of GABAA receptors, originally identified in 1932 from plant alkaloid extracts, and isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and various Corydalis species.
- $38
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CitedL-5-Hydroxytryptophan
T13794350-09-8
L-5-Hydroxytryptophan (L-5-HTP), the immediate precursor in the biosynthesis of SEROTONIN from tryptophan, is used as an antiepileptic and antidepressant.
- $42
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(RS)-(Tetrazol-5-yl)glycine
T16801138199-51-6
(RS)-(Tetrazol-5-yl)glycine (LY 285265) [(D,L-(tetrazol-5-yl)glycine] is an effective and selective N-methyl-D-aspartate receptor agonist with EC50s of 99 nM for GluN1 GluN2D and 1.7 μM for GluN1 GluN2A.
- $36
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Bicuculline methobromide
T7224666016-70-4
Bicuculline methobromide, a selective GABAA Receptor antagonist with an IC50 value of 3 μM, induces tonic-clonic convulsions in mammals and blocks Ca2+ activated potassium channels. It is applicable in researching epilepsy and related psychiatric disorders.
- TBD
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(-)-(α)-Kainic Acid (hydrate)
T3755758002-62-3
(-)-(α)-Kainic Acid (hydrate) is a potent excitotoxic agent that can induce seizures. (-)-(α)-Kainic Acid (hydrate) is also an agonist of ionotropic glutamate receptor subtypes.
- $564
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Bicuculline methochloride
T7411238641-83-7
Bicuculline methochloride ((+)-Bicuculline; d-Bicuculline), a selective GABAA receptor antagonist, exhibits an IC50 of 3 μM. It induces tonic-clonic convulsions in mammals and blocks Ca2+ activated potassium channels, making it useful for studying epilepsy and related psychiatric disorders [1] [2].
- TBD
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