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Nervous System Disease ModelingAlzheimer's Disease Modeling
Alzheimer’s Disease (AD) is the most common neurodegenerative disorder, characterized by amyloid plaque deposition, Tau protein hyperphosphorylation, and cognitive decline. Commonly used models include transgenic mice such as APP/PS1 and 3xTg-AD, as well as intracerebral injection of Aβ peptides. These models are valuable for screening anti-Aβ aggregation drugs, neuroprotective agents, and candidates targeting Tau pathology.
plx5622
Cited
T71001303420-67-8
PLX5622 is a highly selective, brain-penetrant, and orally active CSF1R inhibitor.
- $97
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Citedβ-Amyloid (25-35)
T14284131602-53-4
β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.
- $64
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colchicine Cited
T032064-86-8
Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to microtubule proteins. Colchicine can be used in the treatment of ventilation and rheumatic diseases.
- $34
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Citedβ-Amyloid (1-42), (rat/mouse) (TFA)
T35499
β-Amyloid (1-42), (rat mouse) (TFA), is a 42-amino acid peptide fragment employed in the study of Alzheimer's disease.
- $163
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okadaic acid
T1638178111-17-8
Okadaic acid is a potent polyether marine toxin that accumulates in the digestive glands of marine mollusks.Okadaic acid is a highly potent and selective protein phosphatase (PP) inhibitor, inhibiting PP1, PP2A, PP3, PP4, and PP5.Okadaic acid activates Wnt β-catenin signaling in human HepaRG cells. catenin signaling in human HepaRG cells.
- $143
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Okadaic acid ammonium salt
T39183175522-42-6
Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC50 = 0.1-0.3 nM) alongside inhibitory effects on PP1 (IC50 = 15-50 nM), PP3 (IC50 = 3.7-4 nM), PP4 (IC50 = 0.1 nM), and PP5 (IC50 = 3.5 nM), but does not affect PP2C. By inhibiting PPs, this compound promotes protein phosphorylation, acts as a tumor promoter, and is involved in inducing tau phosphorylation.
- $1,520
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β-Amyloid (1-40) (TFA)
T75751
β-Amyloid (1-40) TFA, a principal protein in plaques observed in the brains of Alzheimer's disease patients [1], is pivotal in research focused on this neurodegenerative disorder.
- Inquiry Price
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β-Amyloid (42-1), human TFA
T75926
β-Amyloid (42-1), human TFA, a 42-amino acid peptide, represents the inactive form of Amyloid β Peptide (1-42) and is crucial in the development of Alzheimer's disease [1].
- Inquiry Price
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PLX5622 hemifumarate
T12505
PLX5622 hemifumarate is a highly selective, brain-penetrant, and orally active CSF1R inhibitor with an IC50 of 0.016 μM and Ki of 5.9 nM. It allows for extended and specific microglial elimination preceding and during pathology development and demonstrates desirable PK properties in various animals [1] [2].
- $1,168
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β-Amyloid (42-1), human
TP1359317366-82-8
β-Amyloid (42-1), human, is the inactive form of Amyloid β Peptide (1-42), which plays a pivotal role in the pathogenesis of Alzheimer's disease.
- $243
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β-Amyloid (1-42), (rat/mouse)
TP1230166090-74-0
Amyloid (1-42), rat is a polypeptide composed of 42 amino acids. It is toxic to hippocampal slices and can be used in the study of alzheimer's disease.
- TBD
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