Thrombin

Thrombin ( fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions.

Cat. No.	Product name	CAS No.	Purity
T10081	Thrombin inhibitor 1	855998-46-8	98%
T10081	Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).
T12782	RWJ-445167	226566-43-4	98%
T12782	RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
T12301	OM-189	55381-18-5	98%
T12301	OM-189 is a selective inhibitor of synthetic thrombin.
T16377	Odiparcil	137215-12-4	98%
T16377	Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of ...
T16292	NFPS	405225-21-0	98%
T16292	NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competiti...
T41031	Protamine sulfate	9009-65-8	98%
T41031	Protamine sulfate, a cationic peptide, is an anti-heparin compound that enhances lipid-mediated gene transfer and neutralizes the anticoagulant effect of heparin...
T22323	Enoxaparin sodium	679809-58-6	98%
T22323	Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment my...
T22246	Argatroban Monohydrate	141396-28-3	98%
T22246	Argatroban Monohydrate is a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
T68086	Imitrodast	114686-12-3	98%
T68086	Imitrodast is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor for the treatment of immune system disorders, respiratory disorders, and cardiov...
T17265	Ximelagatran	192939-46-1	98%
T17265	Ximelagatran, a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active age...
T11994	Melagatran	159776-70-2	98%
T11994	Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzymes in the coagulation cascade or fibrinoly...
T6295	Dabigatran	211914-51-1	98%
T6295	Dabigatran is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the ri...
T10951	Dabigatran ethyl ester hydrochloride	211914-50-0	98%
T10951	Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a ...
T5519	Bivalirudin	128270-60-0	98%
T5519	Bivalirudin is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.
T0449	Menadione	58-27-5	98%
T0449	Menadione is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after ...
T0389	Dabigatran etexilate	211915-06-9	98%
T0389	Dabigatran is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.
T67959	Pirodomast	108310-20-9	98%
T67959	Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is wea...
T7417	Avatrombopag	570406-98-3	98%
T7417	Avatrombopag is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platele...
T6236	Ozagrel	82571-53-7	98%
T6236	Ozagrel is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrova...
T0438	Proflavine Hemisulfate	1811-28-5	98%
T0438	Proflavine Hemisulfate is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used f...