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Thrombin

Thrombin ( fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions.
Cat. No. Product name CAS No. Purity Chemical Structure
T10081 Thrombin inhibitor 1 855998-46-8 98%
Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).
T12782 RWJ-445167 226566-43-4 98%
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
T12301 OM-189 55381-18-5 98%
OM-189 is a selective inhibitor of synthetic thrombin.
T16377 Odiparcil 137215-12-4 98%
Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of ...
T16292 NFPS 405225-21-0 98%
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competiti...
T41031 Protamine sulfate 9009-65-8 98%
Protamine sulfate, a cationic peptide, is an anti-heparin compound that enhances lipid-mediated gene transfer and neutralizes the anticoagulant effect of heparin...
T22323 Enoxaparin sodium 679809-58-6 98%
Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment my...
T22246 Argatroban Monohydrate 141396-28-3 98%
Argatroban Monohydrate is a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
T68086 Imitrodast 114686-12-3 98%
Imitrodast is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor for the treatment of immune system disorders, respiratory disorders, and cardiov...
T17265 Ximelagatran 192939-46-1 98%
Ximelagatran, a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active age...
T11994 Melagatran 159776-70-2 98%
Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzymes in the coagulation cascade or fibrinoly...
T6295 Dabigatran 211914-51-1 98%
Dabigatran is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the ri...
T10951 Dabigatran ethyl ester hydrochloride 211914-50-0 98%
Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a ...
T5519 Bivalirudin 128270-60-0 98%
Bivalirudin is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.
T0449 Menadione 58-27-5 98%
Menadione is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after ...
T0389 Dabigatran etexilate 211915-06-9 98%
Dabigatran is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.
T67959 Pirodomast 108310-20-9 98%
Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is wea...
T7417 Avatrombopag 570406-98-3 98%
Avatrombopag is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platele...
T6236 Ozagrel 82571-53-7 98%
Ozagrel is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrova...
T0438 Proflavine Hemisulfate 1811-28-5 98%
Proflavine Hemisulfate is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used f...
Thrombin inhibitor 1
T10081
Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).
RWJ-445167
T12782
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
OM-189
T12301
OM-189 is a selective inhibitor of synthetic thrombin.
Odiparcil
T16377
Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of ...
NFPS
T16292
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competiti...
Protamine sulfate
T41031
Protamine sulfate, a cationic peptide, is an anti-heparin compound that enhances lipid-mediated gene transfer and neutralizes the anticoagulant effect of heparin...
Enoxaparin sodium
T22323
Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment my...
Argatroban Monohydrate
T22246
Argatroban Monohydrate is a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
Imitrodast
T68086
Imitrodast is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor for the treatment of immune system disorders, respiratory disorders, and cardiov...
Ximelagatran
T17265
Ximelagatran, a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active age...
Melagatran
T11994
Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzymes in the coagulation cascade or fibrinoly...
Dabigatran
T6295
Dabigatran is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the ri...
Dabigatran ethyl ester hydrochloride
T10951
Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a ...
Bivalirudin
T5519
Bivalirudin is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.
Menadione
T0449
Menadione is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after ...
Dabigatran etexilate
T0389
Dabigatran is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.
Pirodomast
T67959
Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is wea...
Avatrombopag
T7417
Avatrombopag is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platele...
Ozagrel
T6236
Ozagrel is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrova...
Proflavine Hemisulfate
T0438
Proflavine Hemisulfate is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used f...
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