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Metabolism ROR

ROR

Cat No. product name
T0760 Cholesterol Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.
T10210 A-9758 A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing ...
T11308 FM26 FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26  is a potent and allosteric retinoic acid receptor-r...
T12754 RORγt Inverse agonist 8 RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
T13067 TAK-828F TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC...
T13172 TMP780 TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
T14369 AZD-0284 AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
T1659 Melatonine Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
T16787 Vimirogant Vimirogant is a RORγ inhibitor (Ki: <100 nM).
T16832 S18-000003 S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 product...
T16929 SR2211 SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM).
T17108 TMP920 TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
T4050 GSK2981278 GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
T4594 SR 1078 SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.
T4670 SR0987 SR0987 is a RORγt agonist,
T5160 SR3335 SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
T5163 SR1001 SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
T5164 Cabozantinib hydrochloride (849217-68-1(free base)) Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
T7388 GSK805 GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bin...
TQ0007 Cintirorgon Cintirorgon is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.
Cholesterol
T0760CAS 57-88-5
Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.
A-9758
T10210CAS 2055271-22-0
A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing ...
FM26
T11308CAS 2407981-35-3
FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26  is a potent and allosteric retinoic acid receptor-r...
RORγt Inverse agonist 8
T12754CAS 2079892-79-6
RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
TAK-828F
T13067CAS 1854901-94-2
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC...
TMP780
T13172CAS 1422053-03-9
TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
AZD-0284
T14369CAS 2101291-07-8
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
Melatonine
T1659CAS 73-31-4
Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
Vimirogant
T16787CAS 1802706-04-2
Vimirogant is a RORγ inhibitor (Ki: <100 nM).
S18-000003
T16832CAS 2068119-11-7
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 product...
SR2211
T16929CAS 1359164-11-6
SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM).
TMP920
T17108CAS 1421837-45-7
TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
GSK2981278
T4050CAS 1474110-21-8
GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
SR 1078
T4594CAS 1246525-60-9
SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.
SR0987
T4670CAS 303126-97-8
SR0987 is a RORγt agonist,
SR3335
T5160CAS 293753-05-6
SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
SR1001
T5163CAS 1335106-03-0
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
Cabozantinib hydrochloride (849217-68-1(free base))
T5164CAS T5164
Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
GSK805
T7388CAS 1426802-50-7
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bin...
Cintirorgon
TQ0007CAS 2055536-64-4
Cintirorgon is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.