T37587 |
ML 209
|
1334526-14-5
|
98%
|
|
ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription i...
|
T11923 |
Methyl-3β-hydroxycholenate
|
20231-57-6
|
98%
|
|
Methyl-3β-hydroxycholenate is a modulator of RORγ.
|
T13067 |
TAK-828F
|
1854901-94-2
|
98%
|
|
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=...
|
T16787 |
Vimirogant
|
1802706-04-2
|
98%
|
|
Vimirogant is a RORγ inhibitor (Ki: <100 nM).
|
T11308 |
FM26
|
2407981-35-3
|
98%
|
|
FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-rela...
|
T17108 |
TMP920
|
1421837-45-7
|
98%
|
|
TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
|
T12754 |
RORγt Inverse agonist 8
|
2079892-79-6
|
98%
|
|
RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
|
T35321 |
Zymostenol
|
566-97-2
|
98%
|
|
Zymostenol is a RORγ agonist with an EC50 of 1 μM.Zymostenol is a late stage precursor of cholesterol biosynthesis.
|
T13172 |
TMP780
|
1422053-03-9
|
98%
|
|
TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
|
T10210 |
A-9758
|
2055271-22-0
|
98%
|
|
A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing bot...
|
T0760 |
Cholesterol
|
57-88-5
|
98%
|
|
Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.
|
T4050 |
GSK2981278
|
1474110-21-8
|
98%
|
|
GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
|
T14369 |
AZD-0284
|
2101291-07-8
|
98%
|
|
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
|
T9635 |
Cedirogant
|
2055496-11-0
|
98%
|
|
Cedirogant is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.
|
T3S1251 |
Neoruscogenin
|
17676-33-4
|
98%
|
|
1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.
|
T6690 |
T0901317
|
293754-55-9
|
98%
|
|
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
|
T5160 |
SR3335
|
293753-05-6
|
98%
|
|
SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
|
T5163 |
SR1001
|
1335106-03-0
|
98%
|
|
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
|
T2834 |
Nobiletin
|
478-01-3
|
98%
|
|
Nobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (...
|
TQ0007 |
Cintirorgon
|
2055536-64-4
|
98%
|
|
Cintirorgon is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.
|