T11923 |
Methyl-3β-hydroxycholenate
|
20231-57-6
|
98.78%
|
|
Methyl-3β-hydroxycholenate (Methyl 3beta-hydroxychol-5-enoate) is a modulator of RORγ.
|
T13067 |
TAK-828F
|
1854901-94-2
|
98%
|
|
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=...
|
T79464 |
RORγ antagonist 1
|
|
98%
|
|
RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM. It demonstra...
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T79470 |
RORγt inverse agonist 31
|
|
98%
|
|
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (I...
|
T16787 |
Vimirogant
|
1802706-04-2
|
98%
|
|
Vimirogant is a RORγ inhibitor (Ki: <100 nM).
|
T11308 |
FM26
|
2407981-35-3
|
98%
|
|
FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-rela...
|
T17108 |
TMP920
|
1421837-45-7
|
98%
|
|
TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
|
T72252 |
RORγt inverse agonist 14
|
2672496-70-5
|
98%
|
|
RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity. It is employed in...
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T12754 |
RORγt Inverse agonist 8
|
2079892-79-6
|
98%
|
|
RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
|
T35321 |
Zymostenol
|
566-97-2
|
98%
|
|
Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM.Zymostenol is a late stage precursor of cholesterol biosynthesis.
|
T13172 |
TMP780
|
1422053-03-9
|
98%
|
|
TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
|
T10210 |
A-9758
|
2055271-22-0
|
98%
|
|
A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing bot...
|
T0760 |
Cholesterol
|
57-88-5
|
99.94%
|
|
Cholesterol (Cholesteryl alcohol) is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processe...
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T16832 |
S18-000003
|
2068119-11-7
|
99.81%
|
|
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 producti...
|
T4050 |
GSK2981278
|
1474110-21-8
|
99.78%
|
|
GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
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T14369 |
AZD-0284
|
2101291-07-8
|
99.75%
|
|
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
|
T37587 |
ML 209
|
1334526-14-5
|
99.65%
|
|
ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription i...
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T9635 |
Cedirogant
|
2055496-11-0
|
99.57%
|
|
Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.
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T3S1251 |
Neoruscogenin
|
17676-33-4
|
99.5%
|
|
1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.
|
T6690 |
T0901317
|
293754-55-9
|
99.43%
|
|
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
|