LTR

LTR retrotransposons are class I transposable element characterized by the presence of Long Terminal Repeats (LTRs) directly flanking an internal coding region. As retrotransposons, they mobilize through reverse-transcription of their mRNA and integration of the newly created cDNA into another location. Their mechanism of retrotransposition is shared with retroviruses, with the difference that most LTR-retrotransposons do not form infectious particles that leave the cells and therefore only replicate inside their genome of origin.

Cat. No.	Product name	CAS No.	Purity
T15815	LY3295668	1919888-06-4	98%
T15815	LY3295668 is an effective and orally active and highly specific inhibitor of Aurora-A kinase (Ki: 0.8 nM and 1038 nM for AurA and AurB, respectively).
T17191	Bunaprolast	99107-52-5	98%
T17191	Bunaprolast shows significant inhibition of lipoxygenase and TXB2 release. Bunaprolast is a potent inhibitor of LTB4 production in human whole blood.
T15002	CP-105696	158081-99-3	98%
T15002	CP-105696 is a selective antagonist of Leukotriene B4 Receptor (IC50: 8.42 nM).
TN5164	Trans-Hinokiresinol	17676-24-3	98%
TN5164	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
T13295	Veliflapon	128253-31-6	98%
T13295	Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and ...
TN3983	Ergosta-7,22-dien-3-one	32507-77-0	98%
TN3983	Ergosta-7,22-dien-3-one shows pro-inflammatory property, it can stimulate nitric oxide production, induce the expression of genes, and induce the production of T...
T15813	LY309887	127228-54-0	98%
T15813	LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
T16395	ONO4057	134578-96-4	98%
T16395	ONO4057 is an antagonist of the Leukotriene B4 receptor (IC50: 0.7±0.3 μM).
T14210	Amelubant	346735-24-8	98%
T14210	Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long act...
T10208	A-69412	123606-23-5	98%
T10208	A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other in...
T11487	Fiboflapon	936350-00-4	98%
T11487	Fiboflapon is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition...
T15182	DW-1350	491577-61-8	98%
T15182	DW-1350 is an antagonist of LTB4 receptor.
T11487L	Fiboflapon sodium	1196070-26-4	98%
T11487L	Fiboflapon sodium (GSK2190915) is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of ...
T10960	Darbufelone	139226-28-1	98%
T10960	Darbufelone is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGH...
T9878	CROCONAZOLE	77175-51-0	98%
T9878	Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the syn...
T21504	γ-Linolenic Acid methyl ester	16326-32-2
T21504	γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.
T1677	Montelukast	158966-92-8	100%
T1677	Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked t...
T3738	3-(4-Hydroxyphenyl)-1-propanol	10210-17-0	98.38%
T3738	3-(4-hydroxyphenyl)-1-propanol is a member of the class of compounds known as 1-hydroxy-2-unsubstituted benzenoids.
T3148	MK-571 sodium	115103-85-0	98.69%
T3148	MK-571 is a selective, orally active antagonist of the CysLT1 receptor. MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the...
T22358	Etalocib	161172-51-6	98.92%
T22358	Etalocib is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotr...