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LTR

LTR retrotransposons are class I transposable element characterized by the presence of Long Terminal Repeats (LTRs) directly flanking an internal coding region. As retrotransposons, they mobilize through reverse-transcription of their mRNA and integration of the newly created cDNA into another location. Their mechanism of retrotransposition is shared with retroviruses, with the difference that most LTR-retrotransposons do not form infectious particles that leave the cells and therefore only replicate inside their genome of origin.
Cat. No. Product name CAS No. Purity Chemical Structure
T15815 LY3295668 1919888-06-4 98%
LY3295668 is an effective and orally active and highly specific inhibitor of Aurora-A kinase (Ki: 0.8 nM and 1038 nM for AurA and AurB, respectively).
T17191 Bunaprolast 99107-52-5 98%
Bunaprolast shows significant inhibition of lipoxygenase and TXB2 release. Bunaprolast is a potent inhibitor of LTB4 production in human whole blood.
T15002 CP-105696 158081-99-3 98%
CP-105696 is a selective antagonist of Leukotriene B4 Receptor (IC50: 8.42 nM).
TN5164 Trans-Hinokiresinol 17676-24-3 98%
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
T13295 Veliflapon 128253-31-6 98%
Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and ...
TN3983 Ergosta-7,22-dien-3-one 32507-77-0 98%
Ergosta-7,22-dien-3-one shows pro-inflammatory property, it can stimulate nitric oxide production, induce the expression of genes, and induce the production of T...
T15813 LY309887 127228-54-0 98%
LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
T16395 ONO4057 134578-96-4 98%
ONO4057 is an antagonist of the Leukotriene B4 receptor (IC50: 0.7±0.3 μM).
T14210 Amelubant 346735-24-8 98%
Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long act...
T10208 A-69412 123606-23-5 98%
A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other in...
T11487 Fiboflapon 936350-00-4 98%
Fiboflapon is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition...
T15182 DW-1350 491577-61-8 98%
DW-1350 is an antagonist of LTB4 receptor.
T11487L Fiboflapon sodium 1196070-26-4 98%
Fiboflapon sodium (GSK2190915) is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of ...
T10960 Darbufelone 139226-28-1 98%
Darbufelone is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGH...
T9878 CROCONAZOLE 77175-51-0 98%
Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the syn...
T21504 γ-Linolenic Acid methyl ester 16326-32-2
γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.
T1677 Montelukast 158966-92-8 100%
Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked t...
T3738 3-(4-Hydroxyphenyl)-1-propanol 10210-17-0 98.38%
3-(4-hydroxyphenyl)-1-propanol is a member of the class of compounds known as 1-hydroxy-2-unsubstituted benzenoids.
T3148 MK-571 sodium 115103-85-0 98.69%
MK-571 is a selective, orally active antagonist of the CysLT1 receptor. MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the...
T22358 Etalocib 161172-51-6 98.92%
Etalocib is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotr...
LY3295668
T15815
LY3295668 is an effective and orally active and highly specific inhibitor of Aurora-A kinase (Ki: 0.8 nM and 1038 nM for AurA and AurB, respectively).
Bunaprolast
T17191
Bunaprolast shows significant inhibition of lipoxygenase and TXB2 release. Bunaprolast is a potent inhibitor of LTB4 production in human whole blood.
CP-105696
T15002
CP-105696 is a selective antagonist of Leukotriene B4 Receptor (IC50: 8.42 nM).
trans-Hinokiresinol
TN5164
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
Veliflapon
T13295
Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and ...
Ergosta-7,22-dien-3-one
TN3983
Ergosta-7,22-dien-3-one shows pro-inflammatory property, it can stimulate nitric oxide production, induce the expression of genes, and induce the production of T...
LY309887
T15813
LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
ONO4057
T16395
ONO4057 is an antagonist of the Leukotriene B4 receptor (IC50: 0.7±0.3 μM).
Amelubant
T14210
Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long act...
A-69412
T10208
A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other in...
Fiboflapon
T11487
Fiboflapon is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition...
DW-1350
T15182
DW-1350 is an antagonist of LTB4 receptor.
Fiboflapon sodium
T11487L
Fiboflapon sodium (GSK2190915) is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of ...
Darbufelone
T10960
Darbufelone is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGH...
CROCONAZOLE
T9878
Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the syn...
γ-Linolenic Acid methyl ester
T21504
γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.
Montelukast
T1677
Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked t...
3-(4-Hydroxyphenyl)-1-propanol
T3738
3-(4-hydroxyphenyl)-1-propanol is a member of the class of compounds known as 1-hydroxy-2-unsubstituted benzenoids.
MK-571 sodium
T3148
MK-571 is a selective, orally active antagonist of the CysLT1 receptor. MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the...
Etalocib
T22358
Etalocib is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotr...
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