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Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. In humans is encoded by the IDO1 gene. IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system. Expression of IDO has been described in a number of types of cancer, such as acute myeloid leukemia, ovarian cancer or colorectal cancer. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78235 4-Phenyl-1H-1,2,3-triazole 1680-44-0 98%
4-Phenyl-1H-1,2,3-triazole
4-Phenyl-1H-1,2,3-triazole, an inhibitor of the enzyme IDO1 (IC50: 60 µM), is utilized in cancer research [1].
T78687 IDO1-IN-21 2892432-98-1 98%
IDO1-IN-21
IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].
T78795 IDO1/TDO-IN-6 2948772-71-0 98%
IDO1/TDO-IN-6
IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO. The compound further demo...
T78975 IDO1-IN-22 2126853-16-3 98%
IDO1-IN-22
IDO1-IN-22 (Compound 3) is an inhibitor of IDO1, demonstrating potent activity with biochemical hIDO1 IC50 of 67.4 nM and HeLa hIDO1 IC50 of 17.6 nM. It exhibits...
T79189 1-Isopropyltryptophan 1219485-46-7 98%
1-Isopropyltryptophan
1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].
T82082 IDO1-IN-23 98%
IDO1-IN-23
IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].
T8214 Kushenol E 99119-72-9 98%
Kushenol E
Kushenol E (Flemiphilippinin D) is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has...
T5S0053 Coptisine 3486-66-6 99.91%
Coptisine
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine t...
T4307 PF-06840003 198474-05-4 99.89%
PF-06840003
PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.
T4142 PCC0208009 1668565-74-9 99.89%
PCC0208009
PCC0208009 (IDO-IN-2) is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
T1806 IDO-IN-7 1402836-58-1 99.87%
IDO-IN-7
IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
T4532 Linrodostat 1923833-60-6 99.84%
Linrodostat
Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
TQ0071 Navoximod 1402837-78-8 99.81%
Navoximod
Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
T2718 Palmatine chloride 10605-02-4 99.64%
Palmatine chloride
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
T11615 IDO-IN-12 1888341-29-4 99.61%
IDO-IN-12
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
T11616 IDO-IN-13 2291164-02-6 99.57%
IDO-IN-13
IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
T6543 Indoximod 110117-83-4 99.5%
Indoximod
Indoximod (Indoximod (NLG-8189)) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenas...
T5S0802 Palmatine 3486-67-7 99.49%
Palmatine
1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palma...
T10199 GNF-PF-3777 77603-42-0 99.47%
GNF-PF-3777
GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
T7660 IDO inhibitor 1 1204669-37-3 99.16%
IDO inhibitor 1
IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
4-Phenyl-1H-1,2,3-triazole
T78235
4-Phenyl-1H-1,2,3-triazole, an inhibitor of the enzyme IDO1 (IC50: 60 µM), is utilized in cancer research [1].
IDO1-IN-21
T78687
IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].
IDO1/TDO-IN-6
T78795
IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO. The compound further demo...
IDO1-IN-22
T78975
IDO1-IN-22 (Compound 3) is an inhibitor of IDO1, demonstrating potent activity with biochemical hIDO1 IC50 of 67.4 nM and HeLa hIDO1 IC50 of 17.6 nM. It exhibits...
1-Isopropyltryptophan
T79189
1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].
IDO1-IN-23
T82082
IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].
Kushenol E
T8214
Kushenol E (Flemiphilippinin D) is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has...
Coptisine
T5S0053
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine t...
PF-06840003
T4307
PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.
PCC0208009
T4142
PCC0208009 (IDO-IN-2) is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
IDO-IN-7
T1806
IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
Linrodostat
T4532
Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
Navoximod
TQ0071
Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
Palmatine chloride
T2718
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
IDO-IN-12
T11615
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
IDO-IN-13
T11616
IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
Indoximod
T6543
Indoximod (Indoximod (NLG-8189)) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenas...
Palmatine
T5S0802
1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palma...
GNF-PF-3777
T10199
GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
IDO inhibitor 1
T7660
IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
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TargetMol