Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. In humans is encoded by the IDO1 gene. IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system. Expression of IDO has been described in a number of types of cancer, such as acute myeloid leukemia, ovarian cancer or colorectal cancer. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.

Cat. No.	Product name	CAS No.	Purity
T8214	Kushenol E	99119-72-9	98%
T8214	Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activity....
T5S0053	Coptisine	3486-66-6	98%
T5S0053	1. Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myoca...
T4307	PF-06840003	198474-05-4	98%
T4307	PF-06840003 is a specific and oral active IDO-1 inhibitor.
T4142	PCC0208009	1668565-74-9	98%
T4142	IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
T4532	Linrodostat	1923833-60-6	98%
T4532	BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
TQ0071	Navoximod	1402837-78-8	98%
TQ0071	Navoximod (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
T1847	Necrostatin-1	4311-88-0	98%
T1847	Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
T2718	Palmatine chloride	10605-02-4	98%
T2718	Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
T11615	IDO-IN-12	1888341-29-4	98%
T11615	IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
T11616	IDO-IN-13	2291164-02-6	98%
T11616	IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
T10199	GNF-PF-3777	77603-42-0	98%
T10199	GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
T5S0056	Coptisine chloride	6020-18-4	98%
T5S0056	1. Coptisine chloride can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
T1806	IDO-IN-7	1402836-58-1	98%
T1806	NLG919 is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
T7660	IDO inhibitor 1	1204669-37-3	98%
T7660	IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
T6543	Indoximod	110117-83-4	98%
T6543	Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades...
T39476	NLG802	2071683-99-1	98%
T39476	NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.
T3548	Epacadostat	1204669-58-8	98%
T3548	Epacadostat is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduci...
T9164	BMS-986242	1923844-48-7	98%
T9164	BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
T7181	IDO-IN-1	914638-30-5	98%
T7181	IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively...
T4S0051	Coptisine sulfate	1198398-71-8	98%
T4S0051	1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.