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Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. In humans is encoded by the IDO1 gene. IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system. Expression of IDO has been described in a number of types of cancer, such as acute myeloid leukemia, ovarian cancer or colorectal cancer. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.
Cat. No. Product name CAS No. Purity Chemical Structure
T8214 Kushenol E 99119-72-9 98%
Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activity....
T5S0053 Coptisine 3486-66-6 98%
1. Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myoca...
T4307 PF-06840003 198474-05-4 98%
PF-06840003 is a specific and oral active IDO-1 inhibitor.
T4142 PCC0208009 1668565-74-9 98%
IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
T4532 Linrodostat 1923833-60-6 98%
BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
TQ0071 Navoximod 1402837-78-8 98%
Navoximod (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
T1847 Necrostatin-1 4311-88-0 98%
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
T2718 Palmatine chloride 10605-02-4 98%
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
T11615 IDO-IN-12 1888341-29-4 98%
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
T11616 IDO-IN-13 2291164-02-6 98%
IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
T10199 GNF-PF-3777 77603-42-0 98%
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
T5S0056 Coptisine chloride 6020-18-4 98%
1. Coptisine chloride can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
T1806 IDO-IN-7 1402836-58-1 98%
NLG919 is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
T7660 IDO inhibitor 1 1204669-37-3 98%
IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
T6543 Indoximod 110117-83-4 98%
Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades...
T39476 NLG802 2071683-99-1 98%
NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.
T3548 Epacadostat 1204669-58-8 98%
Epacadostat is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduci...
T9164 BMS-986242 1923844-48-7 98%
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
T7181 IDO-IN-1 914638-30-5 98%
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively...
T4S0051 Coptisine sulfate 1198398-71-8 98%
1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.
Kushenol E
T8214
Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activity....
Coptisine
T5S0053
1. Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myoca...
PF-06840003
T4307
PF-06840003 is a specific and oral active IDO-1 inhibitor.
PCC0208009
T4142
IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
Linrodostat
T4532
BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
Navoximod
TQ0071
Navoximod (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
Necrostatin-1
T1847
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
Palmatine chloride
T2718
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
IDO-IN-12
T11615
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
IDO-IN-13
T11616
IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
GNF-PF-3777
T10199
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
Coptisine chloride
T5S0056
1. Coptisine chloride can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
IDO-IN-7
T1806
NLG919 is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
IDO inhibitor 1
T7660
IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
Indoximod
T6543
Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades...
NLG802
T39476
NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.
Epacadostat
T3548
Epacadostat is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduci...
BMS-986242
T9164
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
IDO-IN-1
T7181
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively...
Coptisine sulfate
T4S0051
1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.
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