Fatty Acid Synthase

Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.Its main function is to catalyze the synthesis of palmitate (C16:0, a long-chain saturated fatty acid) from acetyl-CoA and malonyl-CoA, in the presence of NADPH.

Cat. No.	Product name	CAS No.	Purity
T15429	GSK2194069	1332331-08-4	98%
T15429	GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released C...
TQ0260	Cerulenin	17397-89-6	98%
TQ0260	Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.
TN1751	Hydroxycitric acid	6205-14-7	98%
TN1751	(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
TN1365	Albaspidin AP	59092-91-0	98%
TN1365	Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promisi...
TN4094	Gallocatechin gallate	5127-64-0	98%
TN4094	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
T14570	BI 99179	1291779-76-4	98%
T14570	BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and cent...
TN2535	1-Hydroxy-2-oxopomolic acid	217466-37-0	98%
TN2535	1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
T11266L	FAS-IN-1 Tosylate	T11266L	98%
T11266L	FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.
TN5431	Icariside E4	126253-42-7	98%
TN5431	Icariside E4 is a natural compound derived from Ulmus minor that acts via AMPK phosphorylation and inhibition of MID1IP2 hypolipidation in HepG1 cells.Icariside ...
T4S1421	Praeruptorin B	73069-28-0	98%
T4S1421	Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via t...
T9266	Fatostatin	125256-00-0	98%
T9266	Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating pro...
TJS0387	Desoxyrhaponticin	30197-14-9	98%
TJS0387	1. Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this com...
T0686	Orlistat	96829-58-2	98%
T0686	Orlistat is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor.
T0846	L-Carnitine	541-15-1	98%
T0846	L(-)-Carnitine is an amino acid derivative. L(-)-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subs...
T3322	Trans-Chalcone	614-47-1	98%
T3322	trans-Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
T4380	Ac-CoA Synthase Inhibitor1	508186-14-9	98%
T4380	ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).
T60060	ACSS2-IN-2	2332820-04-7	98%
T60060	ACSS2-IN-2 is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-...
T17180	TVB-3166	1533438-83-3	98%
T17180	TVB-3166 induces apoptosis and inhibits in-vivo xenograft tumor growth. TVB-3166 is a reversible and selective fatty acid synthase inhibitor (IC50s: 42 nM and 8...
T15271	Denifanstat	1399177-37-7	98%
T15271	FASN-IN-2 is a Fatty Acid Synthase (FASN) inhibitor(IC50 of 0.052 μM and an EC50 of 0.072 μM),with potential antineoplastic activity.
T0988	Trimetazidine dihydrochloride	13171-25-0	98%
T0988	Trimetazidine dihydrochloride can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-isch...