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Fatty Acid Synthase

Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.Its main function is to catalyze the synthesis of palmitate (C16:0, a long-chain saturated fatty acid) from acetyl-CoA and malonyl-CoA, in the presence of NADPH.
Cat. No. Product name CAS No. Purity Chemical Structure
T4S1421 Praeruptorin B 73069-28-0 98%
Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via t...
TN2535 1-Hydroxy-2-oxopomolic acid 217466-37-0 98%
1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
TN4094 Gallocatechin gallate 5127-64-0 98%
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TN2083 Pinostrobin chalcone 18956-15-5 98%
Pinostrobin chalcone is a potent inhibitor of triglyceride accumulation, it can inhibit adipogenesis in 3T3-L1 cells, it may have anti-obesity effects through th...
T11266L FAS-IN-1 Tosylate T11266L 98%
FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.
T14570 BI 99179 1291779-76-4 98%
BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and cent...
TN1365 Albaspidin AP 59092-91-0 98%
Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promisi...
TN1751 Hydroxycitric acid 6205-14-7 98%
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
T27307 Fasnall 929978-58-5 98%
Fasnall is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) br...
T36841 IPI-9119 1346564-56-4 98%
IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).
T11267 FASN-IN-1 1808260-84-5 98%
FASN-IN-1 is a fatty acid synthase (FASN) inhibitor .
T21724L Fas C-Terminal Tripeptide Acetate T21724L
Fas C-Terminal Tripeptide Acetate shows inhibitory activity of Fas/FAP-1 binding.
T14298 Rimiducid 195514-63-7
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affin...
T7947 FT113 1630808-89-7 97.68%
FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
TN1803 Isoscoparin 20013-23-4 97.95%
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
TJS0387 Desoxyrhaponticin 30197-14-9 98%
1. Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this com...
T5S0246 Pseudoprotodioscin 102115-79-7 98%
1. Pseudoprotodioscin has moderate cytotoxicity.
TN1440 Beta-Hydroxyisovalerylshikonin 7415-78-3 98.16%
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
T11557 FASN-IN-3 2097262-60-5 98.22%
FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
T9732 VY-3-135 1824637-41-3 98.56%
VY-3-135 is a metastasis inhibitor and an acetyl-​CoA synthetase 2 (ACSS2) modulator.
Praeruptorin B
T4S1421
Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via t...
1-Hydroxy-2-oxopomolic acid
TN2535
1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
Gallocatechin gallate
TN4094
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
Pinostrobin chalcone
TN2083
Pinostrobin chalcone is a potent inhibitor of triglyceride accumulation, it can inhibit adipogenesis in 3T3-L1 cells, it may have anti-obesity effects through th...
FAS-IN-1 Tosylate
T11266L
FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.
BI 99179
T14570
BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and cent...
Albaspidin AP
TN1365
Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promisi...
Hydroxycitric acid
TN1751
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
Fasnall
T27307
Fasnall is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) br...
IPI-9119
T36841
IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).
FASN-IN-1
T11267
FASN-IN-1 is a fatty acid synthase (FASN) inhibitor .
Fas C-Terminal Tripeptide Acetate
T21724L
Fas C-Terminal Tripeptide Acetate shows inhibitory activity of Fas/FAP-1 binding.
Rimiducid
T14298
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affin...
FT113
T7947
FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
Isoscoparin
TN1803
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
Desoxyrhaponticin
TJS0387
1. Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this com...
Pseudoprotodioscin
T5S0246
1. Pseudoprotodioscin has moderate cytotoxicity.
Beta-Hydroxyisovalerylshikonin
TN1440
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
FASN-IN-3
T11557
FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
VY-3-135
T9732
VY-3-135 is a metastasis inhibitor and an acetyl-​CoA synthetase 2 (ACSS2) modulator.
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