Fatty Acid Synthase

Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.Its main function is to catalyze the synthesis of palmitate (C16:0, a long-chain saturated fatty acid) from acetyl-CoA and malonyl-CoA, in the presence of NADPH.

Cat. No.	Product name	CAS No.	Purity
T4S1421	Praeruptorin B	73069-28-0	98%
T4S1421	Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via t...
TN2535	1-Hydroxy-2-oxopomolic acid	217466-37-0	98%
TN2535	1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
TN4094	Gallocatechin gallate	5127-64-0	98%
TN4094	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TN2083	Pinostrobin chalcone	18956-15-5	98%
TN2083	Pinostrobin chalcone is a potent inhibitor of triglyceride accumulation, it can inhibit adipogenesis in 3T3-L1 cells, it may have anti-obesity effects through th...
T11266L	FAS-IN-1 Tosylate	T11266L	98%
T11266L	FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.
T14570	BI 99179	1291779-76-4	98%
T14570	BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and cent...
TN1365	Albaspidin AP	59092-91-0	98%
TN1365	Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promisi...
TN1751	Hydroxycitric acid	6205-14-7	98%
TN1751	(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
T27307	Fasnall	929978-58-5	98%
T27307	Fasnall is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) br...
T36841	IPI-9119	1346564-56-4	98%
T36841	IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).
T11267	FASN-IN-1	1808260-84-5	98%
T11267	FASN-IN-1 is a fatty acid synthase (FASN) inhibitor .
T21724L	Fas C-Terminal Tripeptide Acetate	T21724L
T21724L	Fas C-Terminal Tripeptide Acetate shows inhibitory activity of Fas/FAP-1 binding.
T14298	Rimiducid	195514-63-7
T14298	Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affin...
T7947	FT113	1630808-89-7	97.68%
T7947	FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
TN1803	Isoscoparin	20013-23-4	97.95%
TN1803	Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
TJS0387	Desoxyrhaponticin	30197-14-9	98%
TJS0387	1. Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this com...
T5S0246	Pseudoprotodioscin	102115-79-7	98%
T5S0246	1. Pseudoprotodioscin has moderate cytotoxicity.
TN1440	Beta-Hydroxyisovalerylshikonin	7415-78-3	98.16%
TN1440	Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
T11557	FASN-IN-3	2097262-60-5	98.22%
T11557	FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
T9732	VY-3-135	1824637-41-3	98.56%
T9732	VY-3-135 is a metastasis inhibitor and an acetyl-CoA synthetase 2 (ACSS2) modulator.