T15429 |
GSK2194069
|
1332331-08-4
|
98%
|
|
GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released C...
|
TQ0260 |
Cerulenin
|
17397-89-6
|
98%
|
|
Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.
|
TN1751 |
Hydroxycitric acid
|
6205-14-7
|
98%
|
|
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
|
TN1365 |
Albaspidin AP
|
59092-91-0
|
98%
|
|
Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promisi...
|
TN4094 |
Gallocatechin gallate
|
5127-64-0
|
98%
|
|
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
|
T14570 |
BI 99179
|
1291779-76-4
|
98%
|
|
BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and cent...
|
TN2535 |
1-Hydroxy-2-oxopomolic acid
|
217466-37-0
|
98%
|
|
1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
|
T11266L |
FAS-IN-1 Tosylate
|
T11266L
|
98%
|
|
FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.
|
TN5431 |
Icariside E4
|
126253-42-7
|
98%
|
|
Icariside E4 is a natural compound derived from Ulmus minor that acts via AMPK phosphorylation and inhibition of MID1IP2 hypolipidation in HepG1 cells.Icariside ...
|
T4S1421 |
Praeruptorin B
|
73069-28-0
|
98%
|
|
Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via t...
|
T9266 |
Fatostatin
|
125256-00-0
|
98%
|
|
Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating pro...
|
TJS0387 |
Desoxyrhaponticin
|
30197-14-9
|
98%
|
|
1. Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this com...
|
T0686 |
Orlistat
|
96829-58-2
|
98%
|
|
Orlistat is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor.
|
T0846 |
L-Carnitine
|
541-15-1
|
98%
|
|
L(-)-Carnitine is an amino acid derivative. L(-)-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subs...
|
T3322 |
Trans-Chalcone
|
614-47-1
|
98%
|
|
trans-Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
|
T4380 |
Ac-CoA Synthase Inhibitor1
|
508186-14-9
|
98%
|
|
ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).
|
T60060 |
ACSS2-IN-2
|
2332820-04-7
|
98%
|
|
ACSS2-IN-2 is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-...
|
T17180 |
TVB-3166
|
1533438-83-3
|
98%
|
|
TVB-3166 induces apoptosis and inhibits in-vivo xenograft tumor growth. TVB-3166 is a reversible and selective fatty acid synthase inhibitor (IC50s: 42 nM and 8...
|
T15271 |
Denifanstat
|
1399177-37-7
|
98%
|
|
FASN-IN-2 is a Fatty Acid Synthase (FASN) inhibitor(IC50 of 0.052 μM and an EC50 of 0.072 μM),with potential antineoplastic activity.
|
T0988 |
Trimetazidine dihydrochloride
|
13171-25-0
|
98%
|
|
Trimetazidine dihydrochloride can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-isch...
|