FXR

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.

Cat. No.	Product name	CAS No.	Purity
T13093	Tauro-β-muricholic acid sodium	145022-92-0	98%
T13093	Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
T15818	LY367385	198419-91-9	98%
T15818	LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM ...
T12583L	(-)-PX20606 trans isomer	1268244-88-7	98%
T12583L	(-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).
T11426	Gly-β-MCA	66225-78-3	98%
T11426	Gly-β-MCA, a bile acid, is a sable, intestine-selective, and oral bioactive farnesoid X receptor (FXR) inhibitor.
TN4628	Nelumol A	77836-86-3	98%
TN4628	Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists....
T6344	Sevelamer hydrochloride	152751-57-0	98%
T6344	Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
T8471	Vonafexor	1192171-69-9	98%
T8471	Vonafexor is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
T2968	Hyodeoxycholic acid	83-49-8	98%
T2968	Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
T5574	Guggulsterone	95975-55-6	98%
T5574	Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T29078	Ursodeoxycholic acid sodium	2898-95-5	98%
T29078	Ursodeoxycholic acid sodium is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts a...
T8895	Altenusin	31186-12-6	98%
T8895	Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
T7436	Cilofexor	1418274-28-8	98%
T7436	Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
T31587	DY268	1609564-75-1	98%
T31587	DY-268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 ...
T6690	T0901317	293754-55-9	98%
T6690	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T2015	Fexaramine	574013-66-4	98%
T2015	Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
T6053	Turofexorate Isopropyl	629664-81-9	98%
T6053	Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
T7886	Nidufexor	1773489-72-7	98%
T7886	Nidufexor is an agonist for the farnesoid X receptor (FXR).
T13092	Tauro-Obeticholic acid	863239-61-6	98%
T13092	Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
T4379	Tropifexor	1383816-29-2	98%
T4379	Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T2939	Forskolin	66575-29-9	98%
T2939	Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.