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FXR

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.
Cat. No. Product name CAS No. Purity Chemical Structure
T13093 Tauro-β-muricholic acid sodium 145022-92-0 98%
Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
T15818 LY367385 198419-91-9 98%
LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM ...
T12583L (-)-PX20606 trans isomer 1268244-88-7 98%
(-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).
T11426 Gly-β-MCA 66225-78-3 98%
Gly-β-MCA, a bile acid, is a sable, intestine-selective, and oral bioactive farnesoid X receptor (FXR) inhibitor.
TN4628 Nelumol A 77836-86-3 98%
Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists....
T6344 Sevelamer hydrochloride 152751-57-0 98%
Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
T8471 Vonafexor 1192171-69-9 98%
Vonafexor is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
T2968 Hyodeoxycholic acid 83-49-8 98%
Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
T5574 Guggulsterone 95975-55-6 98%
Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T29078 Ursodeoxycholic acid sodium 2898-95-5 98%
Ursodeoxycholic acid sodium is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts a...
T8895 Altenusin 31186-12-6 98%
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
T7436 Cilofexor 1418274-28-8 98%
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
T31587 DY268 1609564-75-1 98%
DY-268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 ...
T6690 T0901317 293754-55-9 98%
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T2015 Fexaramine 574013-66-4 98%
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
T6053 Turofexorate Isopropyl 629664-81-9 98%
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
T7886 Nidufexor 1773489-72-7 98%
Nidufexor is an agonist for the farnesoid X receptor (FXR).
T13092 Tauro-Obeticholic acid 863239-61-6 98%
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
T4379 Tropifexor 1383816-29-2 98%
Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T2939 Forskolin 66575-29-9 98%
Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
Tauro-β-muricholic acid sodium
T13093
Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
LY367385
T15818
LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM ...
(-)-PX20606 trans isomer
T12583L
(-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).
Gly-β-MCA
T11426
Gly-β-MCA, a bile acid, is a sable, intestine-selective, and oral bioactive farnesoid X receptor (FXR) inhibitor.
Nelumol A
TN4628
Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists....
Sevelamer hydrochloride
T6344
Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
Vonafexor
T8471
Vonafexor is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
Hyodeoxycholic acid
T2968
Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
Guggulsterone
T5574
Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
Ursodeoxycholic acid sodium
T29078
Ursodeoxycholic acid sodium is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts a...
Altenusin
T8895
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
Cilofexor
T7436
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
DY268
T31587
DY-268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 ...
T0901317
T6690
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
Fexaramine
T2015
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
Turofexorate Isopropyl
T6053
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
Nidufexor
T7886
Nidufexor is an agonist for the farnesoid X receptor (FXR).
Tauro-Obeticholic acid
T13092
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
Tropifexor
T4379
Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
Forskolin
T2939
Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
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