T13093 |
Tauro-β-muricholic acid sodium
|
145022-92-0
|
98%
|
|
Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
|
T15818 |
LY367385
|
198419-91-9
|
98%
|
|
LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM ...
|
T12583L |
(-)-PX20606 trans isomer
|
1268244-88-7
|
98%
|
|
(-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).
|
T11426 |
Gly-β-MCA
|
66225-78-3
|
98%
|
|
Gly-β-MCA, a bile acid, is a sable, intestine-selective, and oral bioactive farnesoid X receptor (FXR) inhibitor.
|
TN4628 |
Nelumol A
|
77836-86-3
|
98%
|
|
Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists....
|
T6344 |
Sevelamer hydrochloride
|
152751-57-0
|
98%
|
|
Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
|
T8471 |
Vonafexor
|
1192171-69-9
|
98%
|
|
Vonafexor is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
|
T2968 |
Hyodeoxycholic acid
|
83-49-8
|
98%
|
|
Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
|
T5574 |
Guggulsterone
|
95975-55-6
|
98%
|
|
Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
|
T29078 |
Ursodeoxycholic acid sodium
|
2898-95-5
|
98%
|
|
Ursodeoxycholic acid sodium is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts a...
|
T8895 |
Altenusin
|
31186-12-6
|
98%
|
|
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
|
T7436 |
Cilofexor
|
1418274-28-8
|
98%
|
|
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
|
T31587 |
DY268
|
1609564-75-1
|
98%
|
|
DY-268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 ...
|
T6690 |
T0901317
|
293754-55-9
|
98%
|
|
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
|
T2015 |
Fexaramine
|
574013-66-4
|
98%
|
|
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
|
T6053 |
Turofexorate Isopropyl
|
629664-81-9
|
98%
|
|
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
|
T7886 |
Nidufexor
|
1773489-72-7
|
98%
|
|
Nidufexor is an agonist for the farnesoid X receptor (FXR).
|
T13092 |
Tauro-Obeticholic acid
|
863239-61-6
|
98%
|
|
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
|
T4379 |
Tropifexor
|
1383816-29-2
|
98%
|
|
Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
|
T2939 |
Forskolin
|
66575-29-9
|
98%
|
|
Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
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