yc 1

Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).

Antibiotic YC 17 is a biochemical agent.

YC 170 is a biochemical.

Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors. and hematologic tumors.

BODIPY-C12 Ceramide (B12Cer) is a fluorescently-tagged form of C12 ceramide, with excitation/emission maxima at 505/540 nm, respectively. It is a fluorescently-labeled sphingolipid and has been utilized for quantifying acid sphingomyelinase activity in the plasma of patients with Niemann-Pick disease.

PXYC1 is a ribosomal protein S1 (RpsA) antagonist with Kd values of 0.81 and 0.31 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. During the trans-translation process of Mycobacterium Tuberculosis (Mtb), RpsA plays a key role [1].

PXYC12 is an antagonist of ribosomal protein S1(RpsA). RpsA is essential for the trans-translation process in Mycobacterium Tuberculosis (Mtb). The Kd values of PXYC12 for RpsA-CTD and RpsA-CTD Δ438A is 2.67 and 4.67 μM, respectively [1].

PXYC13 is an antagonist of ribosomal protein S1(RpsA). RpsA is essential for the Mycobacterium Tuberculosis(Mtb) trans-translation process. The Kd values of PXYC13 for RpsA-CTD and RpsA-CTD Δ438A is 7.61 and 8.50 μM, respectively [1].

CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.

YC-137 is a BCL-2 inhibitor, which selectively induces apoptosis of Bcl-2-overexpressing cells and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2.

C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0) is 890041-50-6.

Rhodady C10 (Compound C10) functions as an inhibitor of dynamin I GTPase. It effectively blocks receptor-mediated endocytosis (IC50: 7 μM), a process involving dynamin in clathrin-independent endocytosis, phagocytosis, and caveolae internalization.

Gemcitabine EP Impurity C-13C-15N2 is the 13C and 15N labeled compound of Gemcitabine EP Impurity C.

10-Deoxymethymycin (AntibioticYC 17) exhibits antibiotic activity against Gram-positive bacteria.

Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator.