y15

Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.

AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].

XY153 (compound 8l) is a BD2-selective BET inhibitor that binds BRD4 BD2 with an IC50 of 0.79 nM, BRD3 BD2 with an IC50 of 5.31 nM, and BRD2 BD2 with an IC50 of 5.09 nM. XY153 is used to study acute myeloid leukaemia and cancer.

PY159 is a humanized antibody expressed in CHO cells, targeting TREM1/CD354. It features a human IgG1 heavy chain and a human κ light chain, with a predicted molecular weight (MW) of 143.66 kDa. For its isotype control, see Human IgG1 kappa, Isotype Control.

KGYY15 (Mouse KGYY15), a peptide that targets CD40, exhibits weak inhibition of the CD40-CD40L interaction, with an IC50 exceeding 1 mM. At a concentration of 100 μM, KGYY15 activates the NF-κB pathway by 33%.

Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM. Lunresertib (RP-6306) inhibits the growth of CCNE1-amplified tumor cells in several preclinical xenograft models.

Citenamide (AY-15613) has anticancer and anticonvulsant activity and is used in the study of neurological disorders because of its sleep-promoting properties.

Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.

Bencianol is a semisynthetic flavonoid with anti-spasmogenic activities.

Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).

7-Acetoxy-15-methoxy-10-O-methyldihydrobotrydial is a useful organic compound for research related to life sciences. The catalog number is T125441 and the CAS number is 196796-12-0.

(S)-3-Hydroxy-1,5-diphenylpentan-1-one is a useful organic compound for research related to life sciences and the catalog number is T125654.

methyl 3-(acetyloxy)-15-oxoandrostane-17-carboxylate is a useful organic compound for research related to life sciences and the catalog number is T131436.

TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment.

VNA-932 is an agonist of the vasopressin V2-receptor (IC50: 80.3 nM and 778 nM in human-V2 binding and V1a binding assay).

Raloxifene (LY139481) is a selective estrogen receptor modulator that exhibits both estrogen agonist and antagonist activities at certain sites, with antiviral activity against viruses like Ebola, influenza, and HCV, useful for studying viral infections.

MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.

LY 150310, a histamine H1-receptor antagonist, can alter prostanoid concentrations in vitro and in vivo.

LY 154045 is a selective antagonist of N-methylaspartate.

WAY-151693 is an inhibitor of human collagenase-3 (MMP-13).

WAY 150138 inhibits the herpes simplex virus.

Zy 15109 can be used as inhaled mast cell stabilizer.

OKY 1581 is a new thromboxane synthetase inhibitor

Ciramadol (WY 15705) is a potent, orally active analgesic with both narcotic agonist and antagonist properties, beneficial for postoperative pain treatment research.