toxoplasmosis

Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.

Sulfadiazine (Sulphadiazine) is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing with para-aminobenzoic acid. It is used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.

Acetylspiramycin (Spiramycin B) targets 50S ribosome to inhibit protein synthesis.

Sulfadiazine sodium (Sulfadiazin-natrium) is a sodium salt form of sulfadiazine, an intermediate-acting bacteriostatic, synthetic sulfanilamide derivative.

Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor, suppressing the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM, a hDHFR IC50 of 308 ± 71 nM, and a hDHFR to TgDHFR selectivity ratio of 196.

Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.

Sulfadiazine-D4 is a deuterium labeled Sulfadiazine. Sulfadiazine (T0930) used for the treatment of toxoplasmosis.

Atovaquone-D4 is the deuterium-labeled Atovaquone. Atovaquone (T1491) is a medication used to treat or prevent pneumocystis babesia, malaria, toxoplasmosis, and pneumonia.

ELQ316 is an antiparasitic compound. In mouse models of acute and latent toxoplasmosis, ELQ316 demonstrates high efficacy, with its in vitro IC50 values at the picomolar level.

Antiparasitic agent-28 is an orally active and selective inhibitor of Toxoplasma gondii phenylalanine tRNA synthetase (TgcPheRS), capable of crossing the blood-brain barrier. It effectively inhibits the growth of T. gondii tachyzoites (TgME49-Fluc strain) with an EC50 of 1 nM, as well as alkaline-induced T. gondii bradyzoites (Tg68nLuc strain) with an EC50 of 3 nM, and glutamine-rich medium-induced bradyzoites with an EC50 of 0.1 nM. Antiparasitic agent-28 demonstrates significant anti-toxoplasmosis efficacy in mice infected with TgME49-Fluc tachyzoites and is utilized in studies involving Toxoplasma gondii infections.

Sulfadiazine (Standard) is the standard substance of Sulfadiazine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Sulfadiazine (Sulphadiazine) is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing with para-aminobenzoic acid. It is used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.