template

Sucrose octaacetate is an acetylated derivative of sucrose used as a food additive, binder, and plasticizer. It is also incorporated in many pesticides, insecticides, and other toxic products as a deterrent to accidental poisoning.

Calf thymus DNA (DNA from calf thymus, thymonucleic acid) is a high-quality double-stranded template DNA extracted from bovine thymus. Calf thymus DNA (DNA from calf thymus, thymonucleic acid) is widely applicable in research on DNA-binding anticancer agents, DNA structure and function, and DNA-binding agents.

Glycylglycine (Diglycine) is a dipeptide used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. Glycine is involved in the body's production of DNA, phospholipids, and collagen, and in the release of energy.

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.

POI ligand 1 serves as a template for the non-selective HDAC inhibitor Vorinostat. It functions as a target protein ligand (PROTAC target protein ligand) in the creation of PROTAC HDAC degraders with anti-tumor properties. Additionally, POI ligand 1 is utilized in the synthesis of FF2049.

N-Propylbutylamine is classified as an aliphatic amine, synthesized via the reaction of butylamine with 1-propanol catalyzed by Raney nickel. Its application as a pore-directing template for controlling pore size and surface area properties of microporous mixed metal oxides has been studied.

Chloroxoquinoline is an anticancer agent that disrupts the DNA template of cancer cells, leading to DNA breaks and cell death. It inhibits cell invasion by downregulating the Rho/Rho kinase signaling pathway. In tumor-bearing mouse models, Chloroxoquinoline enhances the radiosensitivity of Lewis lung carcinoma cells and xenograft tumors. However, its long-term efficacy is reduced in rat models due to self-induction of CYP1A and CYP3A. Chloroxoquinoline exhibits broad-spectrum anticancer activity against non-small cell lung cancer (NSCLC), breast cancer, and gastric cancer.

UBP714 is a derivative of the NMDA receptor negative allosteric modulator UBP608. It also enhanced NMDAR mediated field EPSPs in the CA1 region of the hippocampus. UBP714 is a novel template for the development of potent and subunit selective NMDAR potent

Dansyllysine is utilized to study binding conformations of drugs to human serum albumin and is utilized as a template molecule to form molecularly imprinted monolayers (MIMs) useful to produce optical biosensor recognition elements.

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II and strongly competes with UTP incorporation into RNA, with a Ki value of 2.0 μM[1].

'3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II by competitively blocking UTP incorporation into RNA with a dissociation constant (Ki) of 2.0 μM[1].

N-(2-Azidoethyl)betulonamide is a pentacyclic triterpenoid, a derivative of betulonic acid , and an intermediate in the synthesis of betulonic acid derivatives within vitrocancer cell cytotoxicity.1 1.Suman, P., Patel, A., Solano, L., et al.Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugatesTetrahedron73(29)4214-4226(2017)

HBV-IN-16 is a quinoline derivative, which has an effective inhibitory effect on covalent closed circular DNA (cccDNA). CccDNA is the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-16 has potential in the research of HBV infection.

D3R Ligand 1 (compound 23b) is a potent, selective antagonist of the dopamine D3 receptor (Ki=66 nM), incorporating a THPB template. It inhibits both G-protein- and β-arrestin-mediated signaling pathways [1].

Ac-LDEETGEFL-NH2 is a 9-mer peptide with a high binding affinity with Keap1 (KD2: 172 nM) and interacts in the Kelch binding pockets. Ac-LDEETGEFL-NH2 can be applied as a probe after being linked to FITC and used as a template in studies about KEAP1/NRF2 inhibitors.

Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent featuring an azide group and serves as a crosslinker-E3 ligase ligand conjugate. This compound is utilized as a click-reactive protein degrader building block within PROTAC research and as a template for the synthesis of targeted protein degraders [1].

BChE-IN-20 (compound 7c) is a potent and selective inhibitor of BChE, with IC50 values of 105 nM for eqBChE and 2.3 nM for hBChE. It also inhibits P glycoprotein with an IC50 of 0.27 μM. BChE-IN-20 serves as a promising template for the design and development of pharmaceutical BChE-selective ligands, including inhibitors and fluorogenic probes.

Amyloid β-Protein (3-42), the precursor of Pyr peptide, serves as the foundation of the amyloid template block in Alzheimer's disease when modified to pyroglutamate Aβ (pEAβ) (3-42). This modified form, pEAβ(3-42), hastens the aggregation of Aβ(1-42) although Aβ(1-42) markedly decelerates both the primary and secondary nucleation of pEAβ(3-42) [1].

Nonan-5-ol (5-nonanol) can be used to synthesize molecular imprinting pseudo-template polymers.

(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a multifunctional chemical probe featuring an azide group for use in click chemistry. As a building block and template for synthetic targeted protein degradation models, this compound serves as a linker in the E3 enzyme ligand conjugates pivotal for PROTAC research involving the creation of reactive protein degraders, specifically VH032 conjugates. It engages in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Ethyl coumarin-3-carboxylate, a coumarin derivative, serves as a pseudo-template for the synthesis of Molecularly Imprinted Polymers (MIPs) that specifically recognize aflatoxins.

(±)-Dehydroaltenusin is an antibiotic that serves as a selective inhibitor of eukaryotic DNA polymerase α (pol α), exhibiting an IC50 of 0.68 μM. It can be isolated from the fungus Alternaria tenuis. The compound competitively inhibits the activity of DNA template primers (Ki: 0.23 μM) and non-competitively inhibits the activity of 2'-deoxyribonucleoside 5'-triphosphate substrates (Ki: 0.18 μM). Additionally, (±)-Dehydroaltenusin can induce S-phase cell cycle arrest and apoptosis in cancer cells and is applicable in research on cancers such as human adenocarcinoma.

2-Chloro-6-(furan-2-yl)purine-beta-D-(3'-deoxy-3'-fluoro)riboside is a nucleoside derivative that is a fluoro-modified nucleoside, 6-modified purine nucleoside, halo-nucleoside, and 3'-modified nucleoside; it serves as a scaffold and template.

2-Amino-6-chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine is a nucleoside derivative, specifically a fluoro-modified nucleoside, halo-nucleoside, and 3'-modified nucleoside used as a scaffold and template.