tdf

Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.

(S)-Tenofovir ((S)-PMPA) is the less active S-enantiomer of Tenofovir which is a nucleotide reverse transcriptase inhibitor.

TDFA is an irreversible inhibitor of protein arginine deiminase 4 (PAD4).

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a cell-permeable, irreversible inhibitor specific for caspase-8. Z-IETD-FMK also an inhibitor of granzyme B. Z-IETD-FMK exhibits cell permeability. Z-IETD-FMK can be used in studies of the extrinsic apoptosis pathway, pyroptosis, and programmed necrosis.

GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 μ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of Ba/F3 expressing wild-type FLT3. F3 expressing wild-type FLT3 (wt-FLT3).

9-Propenyladenine (9-PA) is a mutagenic impurity in tenofovir disoproxil fumarate (TDF).