tak 599

Ceftaroline fosamil (TAK-599) is a cephalosporin, with activity against Gram-positive pathogens.

Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection.

T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2].

Ceftaroline hydrochloride (T-91825 HCl, PPI-0903M HCl) is an N-phosphorylated cephalosporin antibiotic and the active form released upon dephosphorylation of the prodrug TAK-599 (ceftaroline fosamil) after it enters the body. Its mechanism of action involves high affinity for penicillin-binding protein 2a (PBP2a), which is associated with methicillin-resistant Staphylococcus aureus (MRSA) resistance (IC50 = 0.90 μg/mL). Ceftaroline hydrochloride kills various Gram-positive and Gram-negative bacteria by blocking bacterial cell wall synthesis, including resistant strains such as MRSA, methicillin-resistant Staphylococcus epidermidis (MRSE), and Streptococcus pneumoniae.