synapses

Aniracetam (Ro 13-5057)(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.

VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors.

Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. It potentially acts by promoting sodium efflux from neurons in the motor cortex, reducing post-tetanic potentiation at synapses. This prevents cortical seizure foci from spreading to adjacent areas and stabilizes the threshold against hyperexcitability. Additionally, it appears to reduce muscle spindle sensitivity to stretch, causing muscle relaxation.

In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand

Acetylcholine perchlorate is the perchlorate salt of acetylcholine. Acetylcholine, an endogenous neurotransmitter at cholinergic synapses, could amplify the action potential of the sarcolemma following by inducing muscle contractions.

Dehydroepiandrosterone sulfate (PB-005) influences the migration of neurons, arborization of dendrites, and formation of new synapses.

S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced

Acetylcholinesterase (ACHE) is an enzyme found in the neuromuscular junction and cholinergic synapses. It catalyzes the hydrolysis of acetylcholine, terminating synaptic neuronal transmission and signal propagation. ACHE can be used for research on biosensors.

Leptin (116-130), a bioactive fragment of leptin, enhances synaptic plasticity in the hippocampus by promoting AMPA receptor trafficking to synapses. It preserves hippocampal synapse integrity and prevents neuronal cell death in amyloid toxicity models, showing promise for Alzheimer's disease (AD) research [1].

Phenytoin (Standard) is the standard substance of Phenytoin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.

L-Glutamic Acid-15N (Standard) is a reference standard of L-Glutamic Acid-15N intended for quantitative analysis, quality control, and related biochemical research applications. L-Glutamic acid-15N is a 15N-labeled substance of L-Glutamic acid. L-Glutamic acid is an excitatory neurotransmitter and also an agonist of metabotropic, ketamine-type, NMDA and AMPA glutamate receptor subtypes. It can directly activate dopamine (DA) to be released from dopaminergic synapses.

RAP-103 is an orally active CCR antagonist that effectively protects synapses by inhibiting and reversing cytoskeletal changes induced by PrPC/NOX signaling. RAP-103 is applicable for research in Alzheimer's disease (AD).