sucnr1

NF-56-EJ40 is an effective and highly selective antagonist of human SUCNR1 with an IC50 of 25 nM and a Ki of 33 nM.

SUCNR1-IN-1 (Compound 20) is a potent SUCNR1 inhibitor with an IC50 of 88 nM against hSUCNR1, used in research on rheumatoid arthritis, liver fibrosis, and obesity [1].

SUCNR1-IN-2 (Statement 35) inhibits both succinate and succinate receptor 1, and is used in research related to neurodegenerative disorders, including neuroinflammation [1].

NF-56-EJ40 hydrochloride is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 hydrochloride has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.

cis-Epoxysuccinic acid is a potential agonist of Succinate receptor 1 and inhibitor of Isocitrate lyase 1 for use in biochemical experiments.