steroid sulfatase

Steroid sulfatase-IN-2 is an active inhibitor of steroid sulfatase (STS), demonstrating an IC50 value of 109.5 nM. Its potential application lies in hormone-dependent cancer research, specifically estrogen-dependent breast and endometrial cancer [1].

Steroid sulfatase-IN-3 (compound 1q) is a potent STS inhibitor with an IC50 value of 25.8 nM and exhibits antiproliferative effects against T-47D estrogen-dependent breast cancer cells, with an IC50 of 1.04 μM [1].

Steroid sulfatase-IN-1 is a highly potent and orally active inhibitor of the enzyme Steroid sulfatase, with an impressive IC50 value of 1.71 μM. This compound exhibits notable antitumor activity, achieving a TGI (tumor growth inhibition) of 51% in vivo, holding great promise in breast cancer research [1].

Steroid sulfatase 17β-HSD1-IN-1 is a highly effective inhibitor of steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) activities, with an IC50 value of 28 nM against cellular human steroid sulfatase. This compound holds significant potential for investigating estrogen-dependent diseases [1].

Steroid sulfatase 17β-HSD1-IN-4 (compound 37) is a potent dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase 17β-HSD1-IN-4 irreversibly inhibits hSTS activity (IC50= 63 nM) and has research value in endometriosis and other estrogen-dependent diseases.

Steroid sulfatase 17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 [17β-HSD1], useful in studying endometriosis and other estrogen-dependent diseases.

Steroid sulfatase-IN-4 (Compound 16) is an irreversible inhibitor of human steroid sulfatase (STS) with an IC50 of 25 nM, and can be used to study endometriosis.

Steroid sulfatase-IN-7 is an irreversible inhibitor of steroid sulfatase (STS) with an IC50 of 0.05 nM against human placental STS, making it suitable for cancer research applications [1].

Steroid Sulfatase-IN-6 (Compound 10c) serves as an irreversible steroid sulfatase (STS) inhibitor, exhibiting a K i value of 0.4 nM against human placenta STS, and is applicable in tumor disease research [1].

Steroid sulfatase-IN-5 (compound 10b) is an effective steroid sulfatase (STS) inhibitor with an IC50 of 0.32 nM that suppresses T-47D breast cancer cell proliferation, exhibiting an IC50 of 35.7 μM, and is utilized in breast cancer research [1].

Steroid sulfatase 17β-HSD1-IN-5 is an irreversible inhibitor of steroid sulfatase (STS) and a reversible, selective inhibitor of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), with IC50 values of 43 nM for 17β-HSD1 and 6.2 μM for 17β-HSD2. This compound is utilized in research related to metabolic diseases, particularly endometriosis [1].

Steroid sulfatase-IN-8 (7), a potent STS inhibitor, exhibits an IC50 of 1 nM in PM and 0.025 nM in JEG-3, respectively [1].

Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS), showing IC50 values of 18 nM as a placental microsomal inhibitor (P.M.) and 0.83 nM in MCF-7 cells. Estrone O-sulfamate can be used to study cancer.

Estrone sulfate sodium (17β-Estrone 3-sulfate) is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone . Estrone sulfate sodium has been investigated as a ligand for targeting organic anion transporting polypeptides f

Irosustat (667-Coumate) is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity.

DU-14, a powerful steroid sulfatase inhibitor, has an IC 50 of 55.8 nM and effectively inhibits MCF-7 cell proliferation with an IC 50 of 38.7 nM. It exhibits neuroprotective properties against neurotoxic Aβ, indicating that by increasing endogenous DHEAS, DU-14 could help alleviate Aβ-induced issues in spatial memory and synaptic plasticity [1] [2] [3].