squalene synthase

RPR107393 free base is a selective and potent inhibitor of squalene synthase (SQS) for the study of neurological disorders and endocrine and metabolic disorders.

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor with potential anti-inflammatory activity. It mitigates statin-induced toxicity in human skeletal muscle cells and protects guinea pigs from simvastatin-induced myotoxicity, useful for research on hypercholesterolemia and HMG-CoA reductase deficiency.

Squalene synthase-IN-1 (compound 1) is a potent antihyperlipidemic agent that inhibits Squalene Synthase, demonstrating exceptional antioxidant and anti-inflammatory activities. It significantly reduces glucose and oxidative stress levels without causing toxicity [1].

WC-9 is a squalene synthase inhibitor. It acts by binding to TcSQS and HsSQS.

Zaragozic acid C is an effective inhibitor of squalene synthase.

Squalestatin 2 is an inhibitor of squalene synthase.

Squalestatin 3 is an inhibitor of squalene synthase.

DF-461 is an inhibitor of squalene synthase.

YM-53601 is a potent squalene synthase (SQS) inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits farnesyl diphosphate farnesyltransferase 1 (FDFT1).YM-53601 exhibits potential antiviral activity and enhances adriamycin-mediated HCC arrest and cell death in vivo. MJN228 is a lipid-based enzyme.

Zaragozic acid D inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.

Zaragozic acid D(2) inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.

E5700 is a novel squalene synthase inhibitor with oral activity.

J-104118 potentially inhibits squalene synthase.

YM-75440 is an squalene synthase inhibitor with oral activity.

BMS-188494 is a squalene synthase inhibitor used as an anti-cholesterol drug.

FIN56, a specific inducer of ferroptosis, is identified by its IUPAC name [1,3,8-trihydroxy-6-methylanthracen-9(10H)-one].

BMS-187745 is a squalene synthase inhibitor.

Schizostatin is an inhibitor of squalene synthase with an IC50 value of 0.84 μM.

Zaragozic acid A trisodium, a metabolite produced by fungi, serves as a reversible competitive inhibitor of squalene synthase.