spp 1

Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) is a mouse-derived antibody that targets and inhibits mouse, rat, and human Osteopontin/SPP1. It significantly suppresses tumour growth in CT26 and MC38 mouse tumour models and attenuates VSMC migration.

Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived IgG2c, κ antibody inhibitor targeting mouse osteopontin/SPP1.

Anti-Mouse osteopontin/SPP1 Antibody (100D3) is an antibody derived from mouse IgG2c kappa, targeting osteopontin/SPP1.

SPP-DM1, a drug-linker conjugate for antibody-drug conjugates (ADC), demonstrates potent antitumor activity. It comprises DM1 (a potent microtubule-disrupting agent) connected through the ADC linker SPP[1].

Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity.

Aliskiren (CGP 60536) D6 Hydrochloride is a deuterium-labeled Aliskiren. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM).

Aliskiren (CGP 60536) is an orally active and potent renin inhibitor (IC50: 1.5 nM) with antihypertensive activity for the treatment of various cardiovascular diseases.

Aliskiren fumarate, an orally active, highly potent, and selective renin inhibitor with an IC50 of 1.5 nM, is utilized in the research of hypertension, cardiovascular diseases, and cancer cachexia.

Avosentan(Ro 67-0565; SPP-301) is a potent endothelin receptor (ETA) antagonist with strong inhibitory effects on endothelin-1-induced contraction and may have protective effects against chronic kidney disease. [2]

LtaS-IN-1 is an effective inhibitor of Lipoteichoic acid synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with MIC values of 0.5 μg/mL.

BAL30072 shows MIC90 values of 4 μg/mL for MDR Acinetobacter spp. and 8 μg/mL for MDR P. aeruginosa, respectively[1][2]. BAL-30072, a siderophore sulfactam, is a monocyclic beta-lactam antibiotic, with activity against multiresistant gram-negative bacilli

Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].

NO2-SPP-sulfo-Me is a cleavable linker used in the synthesis of antibody-drug conjugates (ADC)[1].

Sulfo-DMAC-SPP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs) [1].

Tigemonam is an orally administered monocyclic β-lactam antibiotic effective at inhibiting many bacterial strains at concentrations of 1 microgram/ml or lower. It targets Escherichia coli, Klebsiella spp., Enterobacter aerogenes, Citrobacter diversus, Proteus spp., Providencia spp., Aeromonas hydrophila, Salmonella spp., Shigella spp., Serratia marcescens, and Yersinia enterocolitica.

Piliformic acid is a fungal metabolite found in [N. pseudotrichia] with diverse biological activities. It is cytotoxic to BC-1 human breast cancer cells (IC50 = 5 μg/ml) and active against [L. braziliensis] amastigotes (IC50 = 78.5 μM). It also shows activity against the plant pathogenic fungi [C. gloeosporioides] (MIC = 292 μM).

GT-1 (LCB10-0200) is a siderophore-linked cephalosporin compound that effectively combats clinical isolates of various bacterial species, including P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, and Enterobacter aerogenes.

Diethofencarb is a fungicide that is highly active against Botrytis cinerea and Benzimidazole-resistant strains of Botryis spp. Diethofencarb acts as fungal agrochemicals [1].

Y18501, an oxysterol-binding protein (OSBPI) inhibitor structurally akin to Oxathiapiprolin, demonstrates potent inhibition against Phytophthora spp. and Pseudoperonospora cubensis with EC50 values between 0.0005 and 0.0046 μg/mL. It exhibits exceptional protective and curative effects on P. cubensis. When used in tandem with Chlorothalonil, Y18501 markedly enhances the suppression of P. cubensis [1].

Fosthiazate is a chiral organophosphorus nematicide that acts by binding to and inhibiting acetylcholinesterase (AChE).

Salvileucalin A, a neo-clerodane diterpenoid, is extracted from the aerial parts of Salvia leucantha. [1]

Polypectate sodium, a principal constituent of cell wall polysaccharides (pectins), serves as a carbon source and triggers polygalacturonase production. It is also employed to assess alkaline-active and stable pectate lyases from Streptomyces spp., and to investigate the optimization of polygalacturonase synthesis from Xanthophyllum spp. under various reaction conditions [1].

Physcion-8-O-β-gentiobioside, an anthraquinone glycoside, has been isolated from the roots of rhubarb [1].

Kopsinine, an indole alkaloid, is derived from the flowers of the periwinkle plant (Vinca spp.) [1].