sms1

SMS1-IN-1 is a potent inhibitor of sphingomyelin synthase 1 (SMS1, IC50 = 2.1 μM), and can be used in the atherosclerosis studies.

Malabaricone C is a bioactive chemical.

SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity.

SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.

OSM-S-106 is a pro-inhibitor that inhibits PfAsnRS through enzyme-mediated production of an Asn-OSM-S-106 adduct, inhibits protein translation, and activates the amino acid starvation response. OSM-S-106 exhibits selective activity against Plasmodium blood and liver stages and shows low intrinsic clearance by human microsomes [1].

SMS2-IN-1 is an effective and highly selective sphingomyelin synthetase 2 (SMS2) inhibitor with IC50 of 6.5 nM and Kd of 37 nM. Sms2-in-1 is 150 times more selective to SMS2 than SMS1 (IC50 is 1000 nM).

WYFA-15 is an inhibitor of sphingomyelin synthase 1 (SMS1) that has been shown to protect mice from lethal SFTSV infection and reduce the replication and pathogenicity of SARS-CoV-2. WYFA-15 is applicable for antiviral research.