sm4

SM4 is a SOX18 small molecule inhibitor of HemSC vessel formation in vivo.

DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against field isolates of both P. falciparum and P. vivax.

NCATS-SM4420 (Compound A35) is an orally effective ligand for the thyroid-stimulating hormone receptor (TSHR) that inhibits the proliferation of MDA-T32 and MDA-T85 cells both in vitro and in vivo, with IC50 values of 0.71 μM and 0.38 μM, respectively. Additionally, it suppresses the metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds potential for research in the field of thyroid cancer.

NCATS-SM4487 is a highly selective inhibitor of GALK1 with an IC50 of 0.05 μM.

DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target for malaria treatmen

SM 4470 is an imidazole derivative with antifungal properties.

Xevinapant hydrochloride (AT-406 HCl) , an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide.

SM-433 is a Smac mimetic and inhibitor of inhibitors of apoptosis (IAPs). SM-433 has a strong affinity for XIAP BIR3 protein (IC50 <1 μM).

SM-433 hydrochlorid is a Smac mimetic, an inhibitor of inhibitory apoptosis proteins (IAPs). SM-433 hydrochlorid is able to bind XIAP BIR3 protein with a potent IC50 <1 μM.

Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.

3β-Cholic Acid (Standard) is a reference standard of 3β-Cholic Acid intended for quantitative analysis, quality control, and related biochemical research applications.

Deoxycholic Acid 3-O-β-D-Glucuronide Disodium Salt (Standard) is a reference standard of Deoxycholic Acid 3-O-β-D-Glucuronide Disodium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

3-Oxodeoxycholic Acid (Standard) is a reference standard of 3-Oxodeoxycholic Acid intended for quantitative analysis, quality control, and related biochemical research applications.

Tauro-ω-Muricholic Acid Sodium Salt (Standard) is a reference standard of Tauro-ω-Muricholic Acid Sodium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

4-CHOLENIC ACID-3-ONE (Standard) is a reference standard of 4-CHOLENIC ACID-3-ONE intended for quantitative analysis, quality control, and related biochemical research applications.

7α-Hydroxy-3-oxochol-4-en-24-oic Acid-[13C3] in Methanol (Standard) is a reference standard of 7α-Hydroxy-3-oxochol-4-en-24-oic Acid-[13C3] in Methanol intended for quantitative analysis, quality control, and related biochemical research applications.

L-3,3`-Diiodothyronine (T2) (Standard) is a reference standard of L-3,3`-Diiodothyronine (T2) intended for quantitative analysis, quality control, and related biochemical research applications.

18-Hydroxycortisone in Methanol (Standard) is a reference standard of 18-Hydroxycortisone in Methanol intended for quantitative analysis, quality control, and related biochemical research applications.

Dehydroepiandrosterone Glucuronide (Standard) is a reference standard of Dehydroepiandrosterone Glucuronide intended for quantitative analysis, quality control, and related biochemical research applications.

5α-Dihydrocorticosterone in Methanol (Standard) is a reference standard of 5α-Dihydrocorticosterone in Methanol intended for quantitative analysis, quality control, and related biochemical research applications.

5α-Dihydrocortisone (Standard) is a reference standard of 5α-Dihydrocortisone intended for quantitative analysis, quality control, and related biochemical research applications.

Prostaglandin A2-[d4] in Ethyl acetate (Standard) is a reference standard of Prostaglandin A2-[d4] in Ethyl acetate intended for quantitative analysis, quality control, and related biochemical research applications.

N-Acetyl-S-(2-carbamoylethyl)-L-cysteine (unlabelled) (Standard) is a reference standard of N-Acetyl-S-(2-carbamoylethyl)-L-cysteine (unlabelled) intended for quantitative analysis, quality control, and related biochemical research applications.

N-Acetyl-S-(3-hydroxypropyl)-L-cysteine Dicyclohexylamine Sa (Standard) is a reference standard of N-Acetyl-S-(3-hydroxypropyl)-L-cysteine Dicyclohexylamine Sa intended for quantitative analysis, quality control, and related biochemical research applications.