s101

S101 is an inhibitor of proliferating T-cells, rescuing mice from superantigen-induced shock.

EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.

Navoximod phosphate is an indoleamine 2,3-dioxygenase (IDO) inhibitor, immunomodulator and antineoplastic.

LAS101057 is a novel orally available and potent and selective A2B receptor antagonist for the study of asthma.

ADS1017 is an antagonist of histamine receptor (histamine receptor) and muscarinic receptor (muscarinic receptor), displaying strong affinity for hH3R, hH4R, hM2R, and hM4R with pKi values of 6.8, 5.5, 7.4, and 7.2, respectively. In mouse models of pain induced by Capsaicin or Oxaliplatin, ADS1017 exhibits analgesic and anti-hyperalgesic effects.

KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.

HGS101 is a fully humanized CCR5 monoclonal antibody that exhibits high affinity for CCR5. It binds to the second extracellular loop (ECL-2) and functions as a signaling antagonist. HGS101 restores the inhibitory effect of Maraviroc in Maraviroc-resistant HIV-1 infected PBMCs. In an uninfected simian immunodeficiency virus model of rhesus monkeys, HGS101 shows anti-HIV activity by inhibiting CCR5 signaling.

KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.

Lorundrostat (MT-4129) is an aldosterone synthase inhibitor with antihypertensive activity that lowers systolic blood pressure.

Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.

EVT-101 free base, also known as ENS-101, is an experimental compound for investigations involving major depressive disorder. EVT-101 free base functions as a selective antagonist of the NMDA receptor subunit 2B (NR2B). EVT-101 free base is applicable to neuropharmacology, glutamatergic neurotransmission, and central nervous system signaling research.

Lumichrome is an endogenous compound in humans, produced by photodegradation of riboflavin. It utilizes a p53-dependent mechanism to inhibit growth and induce apoptosis in human lung cancer cells.

Foslevcromakalim (QLS-101) is an adenosine triphosphate-sensitive potassium channel (KATP) opener that is converted to its active form by alkaline phosphatase in vivo. It reduces intraocular pressure in normotensive mice and is suitable for glaucoma research.

Zilovertamab vedotin is a novel antibody-drug conjugate (ADC) constructed by conjugating the humanized monoclonal antibody zilovertamab with the anti-microtubule cytotoxic drug monomethyl vedotin. It binds to ROR1 on the surface of tumor cells, promotes rapid internalization and trafficking of the complex to lysosomes, followed by ADC cleavage and release of monomethyl vedotin, thereby inducing tumor cell apoptosis. It can be used in cancer-related research.

Mapatumumab (HGS-ETR1) is a fully human agonistic monoclonal antibody targeting the TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab exhibits anticancer activity, primarily by inducing tumor cell death through the activation of the death receptor-mediated apoptosis pathway. Mapatumumab is intended for use in cancer research.

Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours.

INBRX-105 is a recombinant humanized bispecific antibody that targets programmed death-ligand 1 (PD-L1) and 4-1BB (CD137), exhibiting potential checkpoint inhibition, immune stimulation, and anti-tumor activity. By binding to 4-1BB on activated T-lymphocytes and PD-L1 on tumor cells, INBRX-105 enhances T-cell co-stimulation and inhibits PD-L1-mediated T-cell suppression, potentially reducing tumor growth. It demonstrates anti-tumor efficacy and increased T-cell frequency in patients with solid tumors and in vivo. Molecular weight: 101.9 kD.

Sodium dodecylbenzenesulfonate (Bio-Soft S 101 sodium) is a non-ionic surfactant frequently used in cleaning and maintaining industrial equipment. It demonstrates strong cleaning properties and environmental compatibility, effectively removing oil, dirt, and other contaminants. Moreover, this compound finds application in the textile, paper, and leather industries for dye fixing and stabilization. While it is not directly used in the medical field, it plays a significant role in industrial and laboratory research.

Tinostamustine, also known as EDO-S101, is an alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule. EDO-S101 is a functional pan-histone-deacetylase inhibitor and is assumed to potentiate the alkylating activity of the compound and/or may help to overcome resistance to other therapeutic agents.