s101

S101 is an inhibitor of proliferating T-cells, rescuing mice from superantigen-induced shock.

EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.

LAS101057 is a novel orally available and potent and selective A2B receptor antagonist for the study of asthma.

ADS1017 is an antagonist of histamine receptor (histamine receptor) and muscarinic receptor (muscarinic receptor), displaying strong affinity for hH3R, hH4R, hM2R, and hM4R with pKi values of 6.8, 5.5, 7.4, and 7.2, respectively. In mouse models of pain induced by Capsaicin or Oxaliplatin, ADS1017 exhibits analgesic and anti-hyperalgesic effects.

KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.

Navoximod phosphate is an indoleamine 2,3-dioxygenase (IDO) inhibitor, immunomodulator and antineoplastic.

Tinostamustine, also known as EDO-S101, is an alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule. EDO-S101 is a functional pan-histone-deacetylase inhibitor and is assumed to potentiate the alkylating activity of the compound and or may help to overcome resistance to other therapeutic agents.