rt4

ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity

Pseudoginsenoside RT4 is a bioactive tetracyclic triterpenoid compound administrable orally and extracted from Panax pseudoginsengsubsp. Himalaicus. It lowers the levels of pro-inflammatory cytokines [TNF-α, IL-6, and IL-1β] while increasing IL-10 levels. Additionally, it modulates gut microbiota composition and exhibits anti-inflammatory properties. Pseudoginsenoside RT4 is utilized in ulcerative colitis research.

SIRT4-IN-1 (compound 69) is a selective inhibitor of Sirtuin 4 (Sirt4) with an IC50 value of 16 μM. It does not exhibit significant effects on other sirtuin isoforms.

PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.

Oxaliplatin (L-OHP) is a DNA alkylating agent and DNA synthesis inhibitor. Oxaliplatin induces cellular autophagy and DNA cross-linking damage, thereby inhibiting DNA replication and transcription and leading to cell death. Oxaliplatin is unstable in chlorine-containing systems; dissolution in saline or PBS is not recommended. A 5% glucose/dextrose solution can be used to prepare the solution for in vivo administration.

24-Hydroxy-25-ethoxy-3,4-seco- is a natural product for research related to life sciences. The catalog number is TN5950 and the CAS number is 1392210-81-9.

PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.