ri-2

RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.

RI(dl)-2 TFA is a potent and selective inhibitor of RAD51-mediated D-loop formation, with an IC50 of 11.1 μM, and inhibits homologous recombination (HR) activity in human cells with an IC50 of 3.0 μM [1].

5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside used in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.

AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.

RI-STAD-2 is a high-affinity peptide that interferes with the regulatory subunit RI of protein kinase A (PKA). It disrupts the binding between A-kinase anchoring proteins (AKAPs) and PKA-RI by mimicking the α-helical domain of AKAPs, interacting with the dimerization/docking (D/D) domain of PKA-RI. This disruption affects the activity and intracellular localization of PKA. RI-STAD-2 is utilized in studying the role of AKAPs and PKA-RI interactions in pathological processes such as cardiovascular diseases and cancer.

PNRI-299 is a selective inhibitor of AP-1 transcription(IC50 of 20 uM ).

SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction phenotypes in neurons.

SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).

SRI-29574 acts as an allosteric modulator of the dopamine transporter (DAT), partially inhibiting its uptake (IC50=2.3 nM) while also moderately inhibiting the uptake of serotonin transporter (SERT) and norepinephrine transporter (NET). This compound serves as a valuable probe for researching the function and regulatory mechanisms of DAT.

STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akap

5'-O-TBDMS-dG is a modified nucleoside, while 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.

5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, is utilized in deoxyribonucleic acid (DNA) or nucleic acid synthesis.