ri 2

RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.

RI(dl)-2 TFA is a potent and selective inhibitor of RAD51-mediated D-loop formation, with an IC50 of 11.1 μM, and inhibits homologous recombination (HR) activity in human cells with an IC50 of 3.0 μM [1].

5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside used in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.

AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.

RI-STAD-2 is a high-affinity peptide that interferes with the regulatory subunit RI of protein kinase A (PKA). It disrupts the binding between A-kinase anchoring proteins (AKAPs) and PKA-RI by mimicking the α-helical domain of AKAPs, interacting with the dimerization/docking (D/D) domain of PKA-RI. This disruption affects the activity and intracellular localization of PKA. RI-STAD-2 is utilized in studying the role of AKAPs and PKA-RI interactions in pathological processes such as cardiovascular diseases and cancer.

RI-OR2-TAT is a brain-penetrable inhibitor targeting β-amyloid (β-Amyloid) oligomerization. It is engineered by integrating the HIV protein transduction domain TAT into RI-OR2. RI-OR2-TAT binds to Aβ42 fibrils with a Kd value of 58-125 nM. It reduces Aβ aggregation and plaque levels, diminishes microglial activation and oxidative damage, and enhances the number of young neurons in the dentate gyrus.

RI-OR2 is a retro-inverso peptide that acts as an amyloid-β (Aβ) oligomerization inhibitor. It binds to fixed β-Amyloid (1-42) monomers and fibrils, with an apparent Kd of 9-12 μM, and also serves as an inhibitor of Aβ(1-42) fibril extension.

KARI 201 is a selective, brain-penetrant, competitive inhibitor of acid sphingomyelinase (ASM) with an IC50 of 338.3 nM. Additionally, KARI 201 acts as an agonist of the growth hormone secretagogue receptor (ghrelin receptor). It is capable of improving the neuropathological characteristics of Alzheimer's disease.

KARI 201 hydrochloride is a selective, brain-penetrant, competitive inhibitor of acid sphingomyelinase (ASM) with an IC50 of 338.3 nM. It also acts as an agonist for the growth hormone-releasing peptide receptor (ghrelin receptor). Additionally, KARI 201 hydrochloride can enhance the neuropathological features of Alzheimer's disease.

24R-Calcipotriol (PRI 2202) is an impurity of Calcipotriol, a ligand of VDR-like receptors.

PNRI-299 is a selective inhibitor of AP-1 transcription(IC50 of 20 uM ).

SRI-22136 is a Delta opioid receptor (DOR) antagonist that can cross the blood-brain barrier with an IC50 of 0.42 nM. It lacks agonistic activity on DOR, MOR, and KOR, functioning solely as an antagonist with IC50 values of 370 nM for MOR and 54 nM for KOR, thereby avoiding addiction/aversion effects. SRI-22136 effectively inhibits DADLE (a DOR agonist)-induced BACE1 activity with an IC50 of 120 nM. It can completely prevent Alzheimer’s disease-like pathology in mouse models and is applicable for Alzheimer's research.

SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction phenotypes in neurons.

Imidazole mustard is an inhibitor of purine nucleoside synthesis.

TSRI265 is a novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo.

SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).

SRI-29574 acts as an allosteric modulator of the dopamine transporter (DAT), partially inhibiting its uptake (IC50=2.3 nM) while also moderately inhibiting the uptake of serotonin transporter (SERT) and norepinephrine transporter (NET). This compound serves as a valuable probe for researching the function and regulatory mechanisms of DAT.

24R-Calcipotriol-d4 (PRI 2202-d4; Impurity D of Calcipotriol-d4) is a deuterium-labeled version of 24R-Calcipotriol. The compound 24R-Calcipotriol (PRI 2202) serves as an impurity of Calcipotriol, which is an analogue of 1,25-Dihydroxyvitamin D3.

Tri-o-cresyl phosphate (Standard) is the standard substance of Tri-o-cresyl phosphate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Tricresyl phosphate is an organophosphate compound. It is used as a plasticizer and diverse other applications.

N,N',N''-Tri-2-pyridinylphosphoric triamide (N,N',N”-Tris(2-pyridinyl) phosphorothioic triamide) is a metal-organic framework.

5,5',5''-[(2,4,6-Trimethyl-1,3,5-benzenetriyl)tri-2,1-ethynediyl]tris[1,3-benzenedicarboxylic acid] is a type of metal-organic framework (MOF).

4',4'''',4'''''''-(2,4,6-Trimethylbenzene-1,3,5-triyl)tri-2,2':6',2''-terpyridine is a type of metal-organic framework (MOF).

STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akap

5'-O-TBDMS-dG is a modified nucleoside, while 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.